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Mfap4 microfibrillar-associated protein 4 [ Mus musculus (house mouse) ]

Gene ID: 76293, updated on 6-May-2021

Summary

Official Symbol
Mfap4provided by MGI
Official Full Name
microfibrillar-associated protein 4provided by MGI
Primary source
MGI:MGI:1342276
See related
Ensembl:ENSMUSG00000042436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110007F23Rik
Expression
Biased expression in lung adult (RPKM 558.6), limb E14.5 (RPKM 254.4) and 11 other tissues See more
Orthologs
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Genomic context

See Mfap4 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61376257..61379536)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61485431..61488708)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (61298946..61302206)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12271 Neighboring gene ring finger protein 112 Neighboring gene mitogen-activated protein kinase 7 Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate derivative binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in UV protection ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in complement activation, lectin pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in elastic fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in elastic fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of collagen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in elastic fiber ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microfibril ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
microfibril-associated glycoprotein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347545.1NP_001334474.1  microfibril-associated glycoprotein 4 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA270684, AL604029
    Consensus CDS
    CCDS83820.1
    UniProtKB/Swiss-Prot
    Q9D1H9
    Related
    ENSMUSP00000038971.7, ENSMUST00000040522.7
  2. NM_001361359.1NP_001348288.1  microfibril-associated glycoprotein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL604029
    Related
    ENSMUST00000126308.2
    Conserved Domains (1) summary
    cd00087
    Location:29247
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
  3. NM_029568.3NP_083844.1  microfibril-associated glycoprotein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_083844.1

    Status: VALIDATED

    Source sequence(s)
    AL604029
    Consensus CDS
    CCDS24813.1
    UniProtKB/Swiss-Prot
    Q9D1H9
    Related
    ENSMUSP00000070848.4, ENSMUST00000064783.10
    Conserved Domains (1) summary
    cd00087
    Location:38256
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61376257..61379536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246411.2XP_030102271.1  microfibril-associated glycoprotein 4 isoform X1

    Conserved Domains (1) summary
    cd00087
    Location:1183
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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