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Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase [ Mus musculus (house mouse) ]

Gene ID: 76429, updated on 11-Apr-2024

Summary

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Official Symbol
Lhppprovided by MGI
Official Full Name
phospholysine phosphohistidine inorganic pyrophosphate phosphataseprovided by MGI
Primary source
MGI:MGI:1923679
See related
Ensembl:ENSMUSG00000030946 AllianceGenome:MGI:1923679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310007H09Rik
Summary
Predicted to enable inorganic diphosphatase activity; phosphatase activity; and protein homodimerization activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in nuclear speck. Predicted to be active in cytosol. Orthologous to human LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 55.0), subcutaneous fat pad adult (RPKM 18.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 76.3 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (132212344..132308149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (132610615..132706420)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8216 Neighboring gene NK1 homeobox 2 Neighboring gene predicted gene, 46021 Neighboring gene STARR-positive B cell enhancer mm9_chr7:139848293-139848593 Neighboring gene STARR-seq mESC enhancer starr_20301 Neighboring gene STARR-seq mESC enhancer starr_20302 Neighboring gene family with sequence similarity 53, member B Neighboring gene EEF1A lysine methyltransferase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:140044265-140044448 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:140050715-140050898 Neighboring gene RIKEN cDNA 1500002F19 gene Neighboring gene BRISC complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity. Lin D, et al. Mol Psychiatry, 2023 Feb. PMID 36460727
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LHPP in Glutamatergic Neurons of the Ventral Hippocampus Mediates Depression-like Behavior by Dephosphorylating CaMKIIalpha and ERK.
    Title: LHPP in Glutamatergic Neurons of the Ventral Hippocampus Mediates Depression-like Behavior by Dephosphorylating CaMKIIα and ERK.
  2. LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity.
    Title: LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inorganic diphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inorganic diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
NP_083885.1
XP_006508360.1
XP_006508361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029609.1 → NP_083885.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase

    See identical proteins and their annotated locations for NP_083885.1

    Status: VALIDATED

    Source sequence(s)
    AK009207, BB399046, BC065789, BY122317
    Consensus CDS
    CCDS21925.1
    UniProtKB/Swiss-Prot
    Q3USP1, Q6P070, Q9D7I5
    Related
    ENSMUSP00000033241.6, ENSMUST00000033241.6
    Conserved Domains (3) summary
    TIGR01458
    Location:11 → 267
    HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458
    pfam13242
    Location:186 → 260
    Hydrolase_like; HAD-hyrolase-like
    pfam13344
    Location:14 → 112
    Hydrolase_6; Haloacid dehalogenase-like hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    132212344..132308149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508298.4 → XP_006508361.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X2

    Conserved Domains (1) summary
    TIGR01458
    Location:43 → 153
    HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458

  2. XM_006508297.2 → XP_006508360.1  phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform X1

    Conserved Domains (1) summary
    TIGR01458
    Location:2 → 153
    HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7I5.1 GenPept UniProtKB/Swiss-Prot:Q9D7I5

Gene LinkOut

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