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Abhd14b abhydrolase domain containing 14b [ Mus musculus (house mouse) ]

Gene ID: 76491, updated on 11-Apr-2024

Summary

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Official Symbol
Abhd14bprovided by MGI
Official Full Name
abhydrolase domain containing 14bprovided by MGI
Primary source
MGI:MGI:1923741
See related
Ensembl:ENSMUSG00000042073 AllianceGenome:MGI:1923741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810013B01Rik
Summary
Predicted to enable hydrolase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in epidermis; nose; and renal calyx. Orthologous to human ABHD14B (abhydrolase domain containing 14B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 174.5), liver adult (RPKM 134.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 57.53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106324936..106330122)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106447737..106452923)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25150 Neighboring gene ribosomal protein L29 Neighboring gene STARR-positive B cell enhancer ABC_E11423 Neighboring gene aminoacylase 1 Neighboring gene abhydrolase domain containing 14A Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly (ADP-ribose) polymerase family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E716

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals. Rajendran A, et al. J Biol Chem, 2022 Jul. PMID 35700823, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals.
    Title: A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative protein-lysine deacylase ABHD14B
Names
CCG1-interacting factor B
abhydrolase domain-containing protein 14B
alpha/beta hydrolase domain-containing protein 14B
protein ABHD14B
NP_083907.3
XP_006511911.1
XP_017169172.1
XP_030100558.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029631.3 → NP_083907.3  putative protein-lysine deacylase ABHD14B

    See identical proteins and their annotated locations for NP_083907.3

    Status: VALIDATED

    Source sequence(s)
    AK007469, BF461776, CJ186593
    Consensus CDS
    CCDS23478.1
    UniProtKB/Swiss-Prot
    Q8VCR7
    UniProtKB/TrEMBL
    A0A087WQN8, E9QN99
    Related
    ENSMUSP00000038755.8, ENSMUST00000048527.15
    Conserved Domains (1) summary
    COG0596
    Location:10 → 209
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106324936..106330122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244698.1 → XP_030100558.1  putative protein-lysine deacylase ABHD14B isoform X1

    UniProtKB/Swiss-Prot
    Q8VCR7
    UniProtKB/TrEMBL
    A0A087WQN8, E9QN99
    Related
    ENSMUSP00000150885.2, ENSMUST00000216130.2
    Conserved Domains (1) summary
    COG0596
    Location:10 → 209
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. XM_017313683.3 → XP_017169172.1  putative protein-lysine deacylase ABHD14B isoform X1

    UniProtKB/Swiss-Prot
    Q8VCR7
    UniProtKB/TrEMBL
    A0A087WQN8, E9QN99
    Related
    ENSMUSP00000141151.2, ENSMUST00000186361.7
    Conserved Domains (1) summary
    COG0596
    Location:10 → 209
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  3. XM_006511848.5 → XP_006511911.1  putative protein-lysine deacylase ABHD14B isoform X1

    See identical proteins and their annotated locations for XP_006511911.1

    UniProtKB/Swiss-Prot
    Q8VCR7
    UniProtKB/TrEMBL
    A0A087WQN8, E9QN99
    Related
    ENSMUSP00000140279.3, ENSMUST00000185347.8
    Conserved Domains (1) summary
    COG0596
    Location:10 → 209
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCR7.1 GenPept UniProtKB/Swiss-Prot:Q8VCR7

Gene LinkOut

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