Il34 interleukin 34 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il34provided by MGI
Official Full Name: interleukin 34provided by MGI
Primary source: MGI:MGI:1923777
See related: Ensembl:ENSMUSG00000031750 AllianceGenome:MGI:1923777
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010004A03Rik
Summary: Predicted to enable cytokine activity; identical protein binding activity; and macrophage colony-stimulating factor receptor binding activity. Involved in microglial cell proliferation; positive regulation of gene expression; and positive regulation of oligodendrocyte differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and mammary gland. Orthologous to human IL34 (interleukin 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 23.9), frontal lobe adult (RPKM 16.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 57.68 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (111467809..111532579, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (110741829..110805949, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-34-NF-kappaB signaling aggravates myocardial ischemic/reperfusion injury by facilitating macrophage recruitment and polarization.
Title: Interleukin-34-NF-κB signaling aggravates myocardial ischemic/reperfusion injury by facilitating macrophage recruitment and polarization.
IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice.
Title: IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice.
TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice.
Title: TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice.
Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models.
Title: Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models.
BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis.
Title: BMP-2 Genome-Edited Human MSCs Protect against Cartilage Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis.
Il-34 regulates MAPKs, PI3K/Akt, JAK and NF-kappaB pathways and induces the expression of inflammatory factors in RA-FLS.
Title: Il-34 regulates MAPKs, PI3K/Akt, JAK and NF-κB pathways and induces the expression of inflammatory factors in RA-FLS.
IL-34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.
Title: IL-34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.
IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
Title: IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
Bone morphogenetic protein 2 controls steroid-induced osteonecrosis of the femoral head via directly inhibiting interleukin-34 expression.
Title: Bone morphogenetic protein 2 controls steroid-induced osteonecrosis of the femoral head via directly inhibiting interleukin-34 expression.
Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1(+) monocytes/macrophages.
Title: Interleukin-34 accelerates intrauterine adhesions progress related to CX3CR1(+) monocytes/macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136458 (e-PCR)
- UniSTS:210444

NoName (e-PCR)
- UniSTS:548215

AW822077 (e-PCR)
- UniSTS:208329

AW743432 (e-PCR)
- UniSTS:208330

AI593503 (e-PCR)
- UniSTS:165600

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables macrophage colony-stimulating factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables macrophage colony-stimulating factor receptor binding	ISO Inferred from Sequence Orthology more info
enables macrophage colony-stimulating factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-34-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in microglial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: interleukin-34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135100.2 → NP_001128572.1 interleukin-34 isoform 1 precursor

See identical proteins and their annotated locations for NP_001128572.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AK008082, AW743837, BY148512

Consensus CDS

CCDS52669.1

UniProtKB/Swiss-Prot

B2ZC71, B2ZC72, Q8R1R4, Q9D8F2

Related

ENSMUSP00000076120.5, ENSMUST00000076846.11

Conserved Domains (1) summary

pfam15036
Location:28 → 184

IL34; Interleukin 34
NM_029646.3 → NP_083922.1 interleukin-34 isoform 2 precursor

See identical proteins and their annotated locations for NP_083922.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region which results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK008082, AW743837, BY148512

Consensus CDS

CCDS52670.1

UniProtKB/Swiss-Prot

Q8R1R4

Related

ENSMUSP00000114398.2, ENSMUST00000150680.2

Conserved Domains (1) summary

pfam15036
Location:28 → 150

IL34; Interleukin 34

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

111467809..111532579 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531485.5 → XP_006531548.1 interleukin-34 isoform X2

See identical proteins and their annotated locations for XP_006531548.1

UniProtKB/Swiss-Prot

Q8R1R4

Conserved Domains (1) summary

pfam15036
Location:28 → 183

IL34; Interleukin 34
XM_030243837.2 → XP_030099697.1 interleukin-34 isoform X1

UniProtKB/Swiss-Prot

B2ZC71, B2ZC72, Q8R1R4, Q9D8F2

Conserved Domains (1) summary

pfam15036
Location:28 → 184

IL34; Interleukin 34
XM_036154368.1 → XP_036010261.1 interleukin-34 isoform X1

UniProtKB/Swiss-Prot

B2ZC71, B2ZC72, Q8R1R4, Q9D8F2

Conserved Domains (1) summary

pfam15036
Location:28 → 184

IL34; Interleukin 34
XM_036154367.1 → XP_036010260.1 interleukin-34 isoform X1

UniProtKB/Swiss-Prot

B2ZC71, B2ZC72, Q8R1R4, Q9D8F2

Conserved Domains (1) summary

pfam15036
Location:28 → 184

IL34; Interleukin 34
XM_036154366.1 → XP_036010259.1 interleukin-34 isoform X1

UniProtKB/Swiss-Prot

B2ZC71, B2ZC72, Q8R1R4, Q9D8F2

Conserved Domains (1) summary

pfam15036
Location:28 → 184

IL34; Interleukin 34
XM_030243838.2 → XP_030099698.1 interleukin-34 isoform X3

Conserved Domains (1) summary

pfam15036
Location:28 → 149

IL34; Interleukin 34