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Msi2 musashi RNA-binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 76626, updated on 21-Apr-2024

Summary

Official Symbol
Msi2provided by MGI
Official Full Name
musashi RNA-binding protein 2provided by MGI
Primary source
MGI:MGI:1923876
See related
Ensembl:ENSMUSG00000069769 AllianceGenome:MGI:1923876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msi2h; 1700105C15Rik
Summary
Enables poly(U) RNA binding activity. Involved in stem cell development. Located in cytoplasm. Part of polysome. Is expressed in several structures, including central nervous system; hair follicle; limb bud; sensory organ; and thymus. Orthologous to human MSI2 (musashi RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.7), whole brain E14.5 (RPKM 15.6) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 C; 11 52.4 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88230208..88609197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88339382..88718306, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm439 Neighboring gene predicted gene, 34366 Neighboring gene coiled-coil domain containing 182 Neighboring gene microRNA 378b Neighboring gene STARR-seq mESC enhancer starr_30328 Neighboring gene predicted gene 11510 Neighboring gene STARR-seq mESC enhancer starr_30343 Neighboring gene STARR-positive B cell enhancer ABC_E10704 Neighboring gene RIKEN cDNA 0610039H22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr11:88476068-88476369 Neighboring gene STARR-positive B cell enhancer ABC_E735 Neighboring gene STARR-seq mESC enhancer starr_30351 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88488860-88488969 Neighboring gene STARR-seq mESC enhancer starr_30353 Neighboring gene STARR-seq mESC enhancer starr_30356 Neighboring gene STARR-seq mESC enhancer starr_30358 Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene STARR-seq mESC enhancer starr_30361 Neighboring gene STARR-positive B cell enhancer ABC_E5262 Neighboring gene STARR-seq mESC enhancer starr_30363 Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene STARR-positive B cell enhancer ABC_E7042 Neighboring gene A kinase anchor protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118040, MGC130496

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in stem cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RNA-binding protein Musashi homolog 2
Names
Musashi2
musashi-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201341.1NP_001188270.1  RNA-binding protein Musashi homolog 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents an alternate splice pattern in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL645601
    Consensus CDS
    CCDS48882.1
    UniProtKB/TrEMBL
    B1AT13
    Related
    ENSMUSP00000103541.2, ENSMUST00000107908.2
    Conserved Domains (1) summary
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  2. NM_001363194.1NP_001350123.1  RNA-binding protein Musashi homolog 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645601, AL732539, CR405681
    Conserved Domains (3) summary
    TIGR01628
    Location:35333
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  3. NM_001363195.1NP_001350124.1  RNA-binding protein Musashi homolog 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK049637, AL645601, AL732539
    Consensus CDS
    CCDS88217.1
    UniProtKB/TrEMBL
    Q2M2Q8
    Related
    ENSMUSP00000103542.2, ENSMUST00000107909.8
    Conserved Domains (2) summary
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  4. NM_001373923.1NP_001360852.1  RNA-binding protein Musashi homolog 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645601, AL732539, CR405681
    Conserved Domains (2) summary
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  5. NM_054043.3NP_473384.1  RNA-binding protein Musashi homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_473384.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BK001483, BQ174763
    Consensus CDS
    CCDS56796.1
    UniProtKB/Swiss-Prot
    Q8BQ90, Q920Q6, Q920Q7
    UniProtKB/TrEMBL
    Q3TE41
    Related
    ENSMUSP00000090470.6, ENSMUST00000092794.12
    Conserved Domains (3) summary
    TIGR01628
    Location:35343
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    88230208..88609197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249302.3XP_011247604.1  RNA-binding protein Musashi homolog 2 isoform X7

    See identical proteins and their annotated locations for XP_011247604.1

    Conserved Domains (3) summary
    TIGR01628
    Location:35351
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  2. XM_036157065.1XP_036012958.1  RNA-binding protein Musashi homolog 2 isoform X13

    Conserved Domains (2) summary
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17104
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  3. XM_006534440.4XP_006534503.1  RNA-binding protein Musashi homolog 2 isoform X8

    Conserved Domains (3) summary
    TIGR01628
    Location:35349
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  4. XM_006534435.4XP_006534498.1  RNA-binding protein Musashi homolog 2 isoform X3

    Conserved Domains (3) summary
    TIGR01628
    Location:35367
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  5. XM_036157064.1XP_036012957.1  RNA-binding protein Musashi homolog 2 isoform X12

    Conserved Domains (2) summary
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17104
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  6. XM_006534438.4XP_006534501.1  RNA-binding protein Musashi homolog 2 isoform X6

    Conserved Domains (3) summary
    TIGR01628
    Location:35345
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  7. XM_006534439.4XP_006534502.1  RNA-binding protein Musashi homolog 2 isoform X5

    Conserved Domains (3) summary
    TIGR01628
    Location:35357
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  8. XM_006534431.4XP_006534494.1  RNA-binding protein Musashi homolog 2 isoform X2

    Conserved Domains (3) summary
    TIGR01628
    Location:35363
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  9. XM_006534432.4XP_006534495.1  RNA-binding protein Musashi homolog 2 isoform X1

    Conserved Domains (3) summary
    TIGR01628
    Location:35375
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  10. XM_006534441.5XP_006534504.1  RNA-binding protein Musashi homolog 2 isoform X10

    Conserved Domains (3) summary
    TIGR01628
    Location:35342
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  11. XM_011249305.4XP_011247607.1  RNA-binding protein Musashi homolog 2 isoform X18

    See identical proteins and their annotated locations for XP_011247607.1

    Conserved Domains (2) summary
    TIGR01628
    Location:39266
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:2699
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  12. XM_030246417.1XP_030102277.1  RNA-binding protein Musashi homolog 2 isoform X19

    Conserved Domains (2) summary
    TIGR01628
    Location:39258
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:2699
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  13. XM_036157066.1XP_036012959.1  RNA-binding protein Musashi homolog 2 isoform X14

    Conserved Domains (2) summary
    TIGR01628
    Location:71298
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:58131
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  14. XM_036157067.1XP_036012960.1  RNA-binding protein Musashi homolog 2 isoform X15

    Conserved Domains (2) summary
    TIGR01628
    Location:71290
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:58131
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
  15. XM_036157068.1XP_036012961.1  RNA-binding protein Musashi homolog 2 isoform X17

    Conserved Domains (2) summary
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  16. XM_036157063.1XP_036012956.1  RNA-binding protein Musashi homolog 2 isoform X11

    Conserved Domains (2) summary
    cd12323
    Location:111184
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12760
    Location:17109
    RRM1_MSI2; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog 2 (Musashi-2 ) and similar proteins
  17. XM_036157062.1XP_036012955.1  RNA-binding protein Musashi homolog 2 isoform X9

    Conserved Domains (3) summary
    TIGR01628
    Location:35337
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cl17169
    Location:17104
    RRM_SF; RNA recognition motif (RRM) superfamily
  18. XM_006534434.4XP_006534497.1  RNA-binding protein Musashi homolog 2 isoform X4

    Conserved Domains (3) summary
    TIGR01628
    Location:35355
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  19. XM_011249304.4XP_011247606.1  RNA-binding protein Musashi homolog 2 isoform X16

    Conserved Domains (2) summary
    cd12323
    Location:135208
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins
  20. XM_030246418.2XP_030102278.1  RNA-binding protein Musashi homolog 2 isoform X20

    UniProtKB/TrEMBL
    B1AT13
    Conserved Domains (1) summary
    cd12576
    Location:2397
    RRM1_MSI; RNA recognition motif 1 in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

RNA

  1. XR_003949528.2 RNA Sequence

  2. XR_004937056.1 RNA Sequence

  3. XR_879764.3 RNA Sequence

  4. XR_388550.4 RNA Sequence

  5. XR_001780073.3 RNA Sequence