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Tmem270 transmembrane protein 270 [ Mus musculus (house mouse) ]

Gene ID: 76629, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem270provided by MGI
Official Full Name
transmembrane protein 270provided by MGI
Primary source
MGI:MGI:1923879
See related
Ensembl:ENSMUSG00000040576 AllianceGenome:MGI:1923879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wbscr28; 1700111I05Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human TMEM270 (transmembrane protein 270). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 99.9) See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 74.88 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134930447..134935587, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134901593..134906733, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene LIM domain kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1309 Neighboring gene predicted gene 10369 Neighboring gene STARR-positive B cell enhancer mm9_chr5:135180028-135180329 Neighboring gene elastin Neighboring gene predicted gene, 30003 Neighboring gene STARR-seq mESC enhancer starr_14552 Neighboring gene STARR-seq mESC enhancer starr_14554 Neighboring gene RIKEN cDNA 9030607J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1310 Neighboring gene claudin 13 Neighboring gene methyltransferase like 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
  2. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. DeSilva U, et al. Genome Res, 2002 Jan. PMID 11779826, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC141057

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 270
Names
Williams-Beuren syndrome chromosome region 28
Williams-Beuren syndrome critical region 28
williams-Beuren syndrome chromosomal region 28 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029681.3 → NP_083957.1  transmembrane protein 270 isoform b

    See identical proteins and their annotated locations for NP_083957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK007170, AV209462
    Consensus CDS
    CCDS39313.1
    UniProtKB/Swiss-Prot
    Q6UJB9
    Related
    ENSMUSP00000045190.6, ENSMUST00000047305.6
    Conserved Domains (1) summary
    pfam15164
    Location:1 → 170
    WBS28; Williams-Beuren syndrome chromosomal region 28 protein homologue

  2. NM_194065.3 → NP_919041.1  transmembrane protein 270 isoform a

    See identical proteins and their annotated locations for NP_919041.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (a).
    Source sequence(s)
    AV209462, BC114542
    Consensus CDS
    CCDS80423.1
    UniProtKB/Swiss-Prot
    Q6UJB9, Q9D9B5
    Related
    ENSMUSP00000144496.2, ENSMUST00000201316.4
    Conserved Domains (1) summary
    pfam15164
    Location:1 → 264
    WBS28; Williams-Beuren syndrome chromosomal region 28 protein homologue

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134930447..134935587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UJB9.1 GenPept UniProtKB/Swiss-Prot:Q6UJB9

Gene LinkOut

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