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Slc10a7 solute carrier family 10 (sodium/bile acid cotransporter family), member 7 [ Mus musculus (house mouse) ]

Gene ID: 76775, updated on 5-Mar-2024

Summary

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Official Symbol
Slc10a7provided by MGI
Official Full Name
solute carrier family 10 (sodium/bile acid cotransporter family), member 7provided by MGI
Primary source
MGI:MGI:1924025
See related
Ensembl:ENSMUSG00000031684 AllianceGenome:MGI:1924025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P7; 2410193C02Rik
Summary
Predicted to enable bile acid transmembrane transporter activity. Involved in bone development and heparin biosynthetic process. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be intrinsic component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Meckel's cartilage; limb segment; skeleton; tooth; and trabecular myocardium. Orthologous to human SLC10A7 (solute carrier family 10 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.4), genital fat pad adult (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C1; 8 37.04 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (79235957..79460641)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (78509323..78734012)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21987 Neighboring gene predicted gene 2225 Neighboring gene STARR-seq mESC enhancer starr_21988 Neighboring gene RNA binding motif protein, X-linked like-1 Neighboring gene STARR-seq mESC enhancer starr_21992 Neighboring gene STARR-seq mESC enhancer starr_21994 Neighboring gene STARR-seq mESC enhancer starr_21995 Neighboring gene ribosomal protein L28 pseudogene Neighboring gene predicted gene, 39203 Neighboring gene VISTA enhancer mm1335 Neighboring gene reeler domain containing 1 pseudogene Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A New SLC10A7 Homozygous Missense Mutation Responsible for a Milder Phenotype of Skeletal Dysplasia With Amelogenesis Imperfecta. Laugel-Haushalter V, et al. Front Genet, 2019. PMID 31191616, Free PMC Article
  2. SLC10A7 mutations cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects. Dubail J, et al. Nat Commun, 2018 Aug 6. PMID 30082715, Free PMC Article
  3. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Godoy JR, et al. Eur J Cell Biol, 2007 Aug. PMID 17628207
  4. High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Brommage R, et al. Bone Res, 2014. PMID 26273529, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular characterization and expression analysis of a novel member of the SLC10 family, SLC10A7, previously known as C4orf13, is reported
    Title: Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • 2410193C02Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in bone development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in heparin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium/bile acid cotransporter 7
Names
Na(+)/bile acid cotransporter 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009981.2 → NP_001009981.1  sodium/bile acid cotransporter 7 isoform c

    See identical proteins and their annotated locations for NP_001009981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks an in-frame exon in the central coding region, compared to variant a. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AC101757, AC139107, AY825928
    Consensus CDS
    CCDS85568.1
    UniProtKB/Swiss-Prot
    Q5PT53
    Related
    ENSMUSP00000147659.2, ENSMUST00000209992.2
    Conserved Domains (1) summary
    pfam13593
    Location:10 → 292
    SBF_like; SBF-like CPA transporter family (DUF4137)

  2. NM_001282108.1 → NP_001269037.1  sodium/bile acid cotransporter 7 isoform d

    See identical proteins and their annotated locations for NP_001269037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (d) lacks an in-frame exon in the 3' coding region, compared to variant a. The encoded isoform (d) is shorter, compared to isoform a.
    Source sequence(s)
    AC101757, AC139107, AK079901
    Consensus CDS
    CCDS85567.1
    UniProtKB/Swiss-Prot
    Q5PT53
    Related
    ENSMUSP00000148199.2, ENSMUST00000209490.2
    Conserved Domains (1) summary
    cl19217
    Location:10 → 278
    SBF; Sodium Bile acid symporter family

  3. NM_001282109.1 → NP_001269038.1  sodium/bile acid cotransporter 7 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (e) lacks an in-frame exon in the central coding region, compared to variant a. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AC101757, AC139107, AK165983
    Conserved Domains (1) summary
    cl19217
    Location:20 → 207
    SBF; Sodium Bile acid symporter family

  4. NM_029736.2 → NP_084012.1  sodium/bile acid cotransporter 7 isoform a

    See identical proteins and their annotated locations for NP_084012.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC101757, AC139107, AK152752
    Consensus CDS
    CCDS40395.1
    UniProtKB/Swiss-Prot
    Q5PT51, Q5PT53, Q8BV58, Q8BYD0, Q9CWD6
    Related
    ENSMUSP00000034111.9, ENSMUST00000034111.10
    Conserved Domains (2) summary
    COG0798
    Location:1 → 306
    ACR3; Arsenite efflux pump ArsB, ACR3 family [Inorganic ion transport and metabolism]
    pfam13593
    Location:10 → 320
    SBF_like; SBF-like CPA transporter family (DUF4137)

RNA

  1. NR_104094.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks two internal exons, compared to variant a. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC101757, AC139107, AY825927

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    79235957..79460641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531489.3 → XP_006531552.1  sodium/bile acid cotransporter 7 isoform X3

    Conserved Domains (1) summary
    cl19217
    Location:10 → 145
    SBF; Sodium Bile acid symporter family

  2. XM_006531491.4 → XP_006531554.1  sodium/bile acid cotransporter 7 isoform X4

    Conserved Domains (1) summary
    cl19217
    Location:10 → 145
    SBF; Sodium Bile acid symporter family

  3. XM_017313009.3 → XP_017168498.1  sodium/bile acid cotransporter 7 isoform X5

    Conserved Domains (1) summary
    cl19217
    Location:10 → 145
    SBF; Sodium Bile acid symporter family

  4. XM_006531488.3 → XP_006531551.1  sodium/bile acid cotransporter 7 isoform X1

    Conserved Domains (1) summary
    pfam13593
    Location:10 → 307
    SBF_like; SBF-like CPA transporter family (DUF4137)

  5. XM_011248545.3 → XP_011246847.1  sodium/bile acid cotransporter 7 isoform X2

    Conserved Domains (1) summary
    cl19217
    Location:10 → 145
    SBF; Sodium Bile acid symporter family

  6. XM_017313010.2 → XP_017168499.1  sodium/bile acid cotransporter 7 isoform X6

    Conserved Domains (1) summary
    cl19217
    Location:10 → 75
    SBF; Sodium Bile acid symporter family

RNA

  1. XR_004934898.1 RNA Sequence

    Related
    ENSMUST00000210630.2

  2. XR_004934899.1 RNA Sequence

  3. XR_387783.3 RNA Sequence

  4. XR_387784.3 RNA Sequence

  5. XR_878921.3 RNA Sequence

  6. XR_004934897.1 RNA Sequence

  7. XR_004934900.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009980.1: Suppressed sequence

    Description
    NM_001009980.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PT53.1 GenPept UniProtKB/Swiss-Prot:Q5PT53

Gene LinkOut

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