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Dok5 docking protein 5 [ Mus musculus (house mouse) ]

Gene ID: 76829, updated on 11-Apr-2024

Summary

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Official Symbol
Dok5provided by MGI
Official Full Name
docking protein 5provided by MGI
Primary source
MGI:MGI:1924079
See related
Ensembl:ENSMUSG00000027560 AllianceGenome:MGI:1924079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700055C10Rik
Summary
Acts upstream of or within neuron differentiation; positive regulation of MAPK cascade; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DOK5 (docking protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 19.0), CNS E14 (RPKM 9.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 92.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (170573722..170721695)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170731807..170879775)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06537 Neighboring gene STARR-seq mESC enhancer starr_06538 Neighboring gene predicted gene, 40003 Neighboring gene predicted gene, 34981 Neighboring gene predicted gene, 35033 Neighboring gene VISTA enhancer mm1402 Neighboring gene STARR-seq mESC enhancer starr_06541 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06543 Neighboring gene STARR-seq mESC enhancer starr_06544 Neighboring gene predicted gene, 46779

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/β-catenin signaling. Xu L, et al. J Musculoskelet Neuronal Interact, 2022 Mar 1. PMID 35234166, Free PMC Article
  2. MicroRNA-141-3p inhibits retinal neovascularization and retinal ganglion cell apoptosis in glaucoma mice through the inactivation of Docking protein 5-dependent mitogen-activated protein kinase signaling pathway. Zhang LQ, et al. J Cell Physiol, 2019 Jun. PMID 30515784
  3. Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway. Wen J, et al. J Mol Cell Cardiol, 2009 Dec. PMID 19800350
  4. The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis. Yasuoka H, et al. PLoS One, 2014. PMID 24551065, Free PMC Article
  5. Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Pan Y, et al. Neurosci Lett, 2013 Oct 11. PMID 23954828

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/beta-catenin signaling.
    Title: Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/β-catenin signaling.
  2. The study suggests that miR-141-3p inhibits retinal neovascularization in glaucoma mice by impeding the activation of the DOK5-mediated MAPK signaling pathway.
    Title: MicroRNA-141-3p inhibits retinal neovascularization and retinal ganglion cell apoptosis in glaucoma mice through the inactivation of Docking protein 5-dependent mitogen-activated protein kinase signaling pathway.
  3. IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
    Title: The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.
  4. Dok5 is necessary for NT-3 signaling to block TrkC-induced apoptosis
    Title: Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis.
  5. FOXO3a, the PI3K/PKB downstream substrate, acts as a transcriptional repressor to inhibit the expression of Dok-5.
    Title: Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
docking protein 5
Names
downstream of tyrosine kinase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163686.1 → NP_001157158.1  docking protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK044148, BY248468, BY657780, CJ064232
    UniProtKB/TrEMBL
    Q6NXY7
    Conserved Domains (3) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
    pfam00169
    Location:8 → 111
    PH; PH domain

  2. NM_029761.4 → NP_084037.3  docking protein 5 isoform 1

    See identical proteins and their annotated locations for NP_084037.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK044148, BY248468, BY657780, CJ064232
    Consensus CDS
    CCDS17125.1
    UniProtKB/Swiss-Prot
    Q8BRI3, Q91ZM9, Q9CSM6
    UniProtKB/TrEMBL
    Q6NXY7
    Related
    ENSMUSP00000029075.5, ENSMUST00000029075.5
    Conserved Domains (3) summary
    cd13164
    Location:133 → 235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9 → 113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
    pfam00169
    Location:8 → 111
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    170573722..170721695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162678.1 → XP_036018571.1  docking protein 5 isoform X1

    Conserved Domains (1) summary
    cl17171
    Location:53 → 129
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZM9.1 GenPept UniProtKB/Swiss-Prot:Q91ZM9

Gene LinkOut

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