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ZNF131 zinc finger protein 131 [ Homo sapiens (human) ]

Gene ID: 7690, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF131provided by HGNC
Official Full Name
zinc finger protein 131provided by HGNC
Primary source
HGNC:HGNC:12915
See related
Ensembl:ENSG00000172262 MIM:604073; AllianceGenome:HGNC:12915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZBTB35; pHZ-10
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 10.2), bone marrow (RPKM 5.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF131 in Genome Data Viewer
Location:
5p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43120914..43176324)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43373818..43429219)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43121016..43176426)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ANXA2R overlapping transcript 1 Neighboring gene uncharacterized LOC100132356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22532 Neighboring gene uncharacterized LOC100506639 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43073915-43074416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43074417-43074916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43078210-43078763 Neighboring gene uncharacterized LOC124900972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43121535-43122103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43122104-43122671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43192643-43193352 Neighboring gene spermine synthase pseudogene Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene tubulin alpha pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. Han X, et al. BMC Genomics, 2008 Oct 11. PMID 18847501, Free PMC Article
  2. ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5. Ding Y, et al. Oncotarget, 2017 Jul 25. PMID 28596487, Free PMC Article
  3. Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization. Oh Y, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159625
  4. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Trappe R, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163020
  5. Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis. Shen X, et al. Biochem Genet, 2022 Oct. PMID 35059934

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
    Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
  2. Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis.
    Title: Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis.
  3. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
    Title: The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
  4. Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability.
    Title: ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5.
  5. identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY to a large number of active, H3K4me3 marked promoters.
    Title: Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.
  6. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131
    Title: UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.
  7. these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor.
    Title: Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization.
  8. SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation.
    Title: Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling.
  9. Interaction between ZNF131 and ERalpha interrupts or prevents ERalpha binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1.
    Title: High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling.
  10. The mechanism of Znf131 nuclear localization, is reported.
    Title: Nuclear trafficking of the POZ-ZF protein Znf131.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
zinc finger protein 131
Names
zinc finger and BTB domain containing 35
zinc finger protein 131 (clone pHZ-10)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297548.3 → NP_001284477.1  zinc finger protein 131 isoform 1

    See identical proteins and their annotated locations for NP_001284477.1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    B4DRL3, P52739, Q6PIF0
    UniProtKB/TrEMBL
    B3KQ42
    Related
    ENSP00000426504.1, ENST00000509156.5
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001330704.2 → NP_001317633.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800

  3. NM_001330705.1 → NP_001317634.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800

  4. NM_001330706.2 → NP_001317635.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    B3KQ42
    Conserved Domains (4) summary
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001330707.2 → NP_001317636.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    B4DRL3, P52739, Q6PIF0
    UniProtKB/TrEMBL
    B3KQ42
    Related
    ENSP00000507111.1, ENST00000682664.1
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001330708.2 → NP_001317637.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    B4DRL3, P52739, Q6PIF0
    UniProtKB/TrEMBL
    B3KQ42
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001330709.2 → NP_001317638.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800

  8. NM_001330710.2 → NP_001317639.1  zinc finger protein 131 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106800

  9. NM_001330711.2 → NP_001317640.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    B3KQ42
    Conserved Domains (4) summary
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001330712.2 → NP_001317641.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    B4DRL3, P52739, Q6PIF0
    UniProtKB/TrEMBL
    B3KQ42
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  11. NM_001330713.2 → NP_001317642.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    B3KQ42
    Related
    ENSP00000423945.1, ENST00000505606.6
    Conserved Domains (4) summary
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  12. NM_001330714.2 → NP_001317643.1  zinc finger protein 131 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS78005.1
    UniProtKB/Swiss-Prot
    B4DRL3, P52739, Q6PIF0
    UniProtKB/TrEMBL
    B3KQ42
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  13. NM_001330715.2 → NP_001317644.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    B3KQ42
    Conserved Domains (4) summary
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  14. NM_001330716.2 → NP_001317645.1  zinc finger protein 131 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC106800
    UniProtKB/TrEMBL
    B3KQ42

  15. NM_001330717.2 → NP_001317646.1  zinc finger protein 131 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC106800
    UniProtKB/TrEMBL
    B3KQ42
    Conserved Domains (4) summary
    COG5048
    Location:167 → 331
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:177 → 198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:309 → 326
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:229 → 254
    zf-H2C2_2; Zinc-finger double domain

  16. NM_001388319.1 → NP_001375248.1  zinc finger protein 131 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    B3KQ42
    Related
    ENSP00000421246.1, ENST00000509634.5
    Conserved Domains (4) summary
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

  17. NM_003432.4 → NP_003423.1  zinc finger protein 131 isoform 2

    See identical proteins and their annotated locations for NP_003423.1

    Status: VALIDATED

    Source sequence(s)
    AC106800
    Consensus CDS
    CCDS43313.1
    UniProtKB/TrEMBL
    B3KQ42
    Related
    ENSP00000305804.4, ENST00000306938.8
    Conserved Domains (4) summary
    sd00017
    Location:256 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:388 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18221
    Location:16 → 128
    BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
    pfam13465
    Location:308 → 333
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    43120914..43176324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    43373818..43429219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52739.2 GenPept UniProtKB/Swiss-Prot:P52739

Gene LinkOut

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