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Klhl2 kelch-like 2, Mayven [ Mus musculus (house mouse) ]

Gene ID: 77113, updated on 9-Oct-2021

Summary

Official Symbol
Klhl2provided by MGI
Official Full Name
kelch-like 2, Mayvenprovided by MGI
Primary source
MGI:MGI:1924363
See related
Ensembl:ENSMUSG00000031605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mav; ABP-KE; AU020744; ABP-KELCH; 6030411N21Rik; 8530402H02Rik
Expression
Broad expression in cortex adult (RPKM 26.9), frontal lobe adult (RPKM 22.8) and 27 other tissues See more
Orthologs
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Genomic context

See Klhl2 in Genome Data Viewer
Location:
8; 8 B3.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65192707..65302821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64739673..64850169, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (67335578..67373716, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxypeptidase E Neighboring gene methylsterol monoxygenase 1 Neighboring gene predicted gene, 46040 Neighboring gene predicted gene, 53437 Neighboring gene predicted gene, 40501 Neighboring gene predicted gene 45405

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4249

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178633.3NP_848748.2  kelch-like protein 2

    See identical proteins and their annotated locations for NP_848748.2

    Status: VALIDATED

    Source sequence(s)
    AC140351, AC152168, AC242529
    Consensus CDS
    CCDS85544.1
    UniProtKB/Swiss-Prot
    Q8JZP3
    Related
    ENSMUSP00000034017.8, ENSMUST00000034017.9
    Conserved Domains (4) summary
    PHA03098
    Location:56573
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:486530
    Kelch; KELCH repeat [structural motif]
    cd18338
    Location:35155
    BTB_POZ_KLHL2_Mayven; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2)
    cd18512
    Location:153282
    BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    65192707..65302821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313011.1XP_017168500.1  kelch-like protein 2 isoform X1

    Conserved Domains (4) summary
    PHA03098
    Location:56606
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:519563
    Kelch; KELCH repeat [structural motif]
    cd18512
    Location:186315
    BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
    cl38908
    Location:35188
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  2. XM_036154378.1XP_036010271.1  kelch-like protein 2 isoform X3

    Conserved Domains (4) summary
    PHA03098
    Location:18568
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:481525
    Kelch; KELCH repeat [structural motif]
    cd18512
    Location:148277
    BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
    cl38908
    Location:1150
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  3. XM_036154379.1XP_036010272.1  kelch-like protein 2 isoform X4

    Conserved Domains (4) summary
    PHA03098
    Location:18535
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:448492
    Kelch; KELCH repeat [structural motif]
    cd18512
    Location:115244
    BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
    cl38908
    Location:1117
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  4. XM_017313012.3XP_017168501.1  kelch-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GQV2
    Related
    ENSMUSP00000147262.2, ENSMUST00000210166.2
    Conserved Domains (4) summary
    PHA03098
    Location:56573
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:486530
    Kelch; KELCH repeat [structural motif]
    cd18338
    Location:35155
    BTB_POZ_KLHL2_Mayven; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2)
    cd18512
    Location:153282
    BACK_KLHL2_Mayven; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2)
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