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ZNF165 zinc finger protein 165 [ Homo sapiens (human) ]

Gene ID: 7718, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF165provided by HGNC
Official Full Name
zinc finger protein 165provided by HGNC
Primary source
HGNC:HGNC:12953
See related
Ensembl:ENSG00000197279 MIM:600834; AllianceGenome:HGNC:12953
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT53; LD65; ZSCAN7
Summary
This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 10.2), placenta (RPKM 2.3) and 15 other tissues See more
Orthologs
all
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Genomic context

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See ZNF165 in Genome Data Viewer
Location:
6p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28080282..28089563)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27950300..27959582)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28048060..28057341)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily B member 8 pseudogene Neighboring gene olfactory receptor family 1 subfamily F member 12, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24342 Neighboring gene zinc finger and SCAN domain containing 12 pseudogene 1 Neighboring gene zinc finger protein 601, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1. Liu P, et al. J Immunol Res, 2022. PMID 35692498, Free PMC Article
  2. Frequent expression of zinc-finger protein ZNF165 in human urinary bladder transitional cell carcinoma. Singh PK, et al. Immunobiology, 2015 Jan. PMID 25214475
  3. Familial t(6;21)(p21.1;p13) translocation associated with male-only sterility. Paoloni-Giacobino A, et al. Clin Genet, 2000 Oct. PMID 11076058
  4. Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. Tirosvoutis KN, et al. Genomics, 1995 Aug 10. PMID 7490084
  5. The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer. Gibbs ZA, et al. Elife, 2020 Jun 9. PMID 32515734, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.
    Title: ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.
  2. The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFbeta signaling in triple-negative breast cancer.
    Title: The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer.
  3. ZNF165 drives the unrestrained activation of transforming growth factor beta (TGFbeta) signalling by directly inactivating the expression of negative feedback pathway regulators, SMURF2, SMAD7 and PMEPA1.
    Title: Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer.
  4. ZNF165 mRNA/protein expression was observed in TCC of human urinary bladder and might be used as a novel diagnostic biomarker and as well a vaccine target in development of urinary bladder cancer specific immunotherapy.
    Title: Frequent expression of zinc-finger protein ZNF165 in human urinary bladder transitional cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 165
Names
cancer/testis antigen 53
zinc finger and SCAN domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376491.1 → NP_001363420.1  zinc finger protein 165 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL121944
    Consensus CDS
    CCDS4643.1
    UniProtKB/Swiss-Prot
    P49910
    UniProtKB/TrEMBL
    Q53Z40
    Related
    ENSP00000507525.1, ENST00000683778.1
    Conserved Domains (4) summary
    smart00431
    Location:45 → 157
    SCAN; leucine rich region
    COG5048
    Location:426 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:344 → 366
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001376492.1 → NP_001363421.1  zinc finger protein 165 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL121944
    Consensus CDS
    CCDS4643.1
    UniProtKB/Swiss-Prot
    P49910
    UniProtKB/TrEMBL
    Q53Z40
    Conserved Domains (4) summary
    smart00431
    Location:45 → 157
    SCAN; leucine rich region
    COG5048
    Location:426 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:344 → 366
    zf-C2H2; Zinc finger, C2H2 type

  3. NM_001376493.1 → NP_001363422.1  zinc finger protein 165 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL121944
    Consensus CDS
    CCDS4643.1
    UniProtKB/Swiss-Prot
    P49910
    UniProtKB/TrEMBL
    Q53Z40
    Conserved Domains (4) summary
    smart00431
    Location:45 → 157
    SCAN; leucine rich region
    COG5048
    Location:426 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:344 → 366
    zf-C2H2; Zinc finger, C2H2 type

  4. NM_001376494.1 → NP_001363423.1  zinc finger protein 165 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL121944
    Conserved Domains (3) summary
    COG5048
    Location:234 → 287
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:210 → 230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:152 → 174
    zf-C2H2; Zinc finger, C2H2 type

  5. NM_003447.4 → NP_003438.1  zinc finger protein 165 isoform a

    See identical proteins and their annotated locations for NP_003438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AL121944, AY083664
    Consensus CDS
    CCDS4643.1
    UniProtKB/Swiss-Prot
    P49910
    UniProtKB/TrEMBL
    Q53Z40
    Related
    ENSP00000366542.1, ENST00000377325.2
    Conserved Domains (4) summary
    smart00431
    Location:45 → 157
    SCAN; leucine rich region
    COG5048
    Location:426 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:344 → 366
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    28080282..28089563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011261.3 → XP_016866750.1  zinc finger protein 165 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    27950300..27959582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356329.1 → XP_054212304.1  zinc finger protein 165 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49910.1 GenPept UniProtKB/Swiss-Prot:P49910

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