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PFN2 profilin 2 [ Gallus gallus (chicken) ]

Gene ID: 771904, updated on 5-Mar-2024

Summary

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Symbol
PFN2provided by CGNC
Full Name
profilin 2provided by CGNC
Primary source
CGNC:7926
See related
Ensembl:ENSGALG00010001115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PFN1; profilin-2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 9 NC_052540.1 (23459531..23464683)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 9 NC_052581.1 (23244963..23250125)

Chromosome 9 - NC_052540.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054149 Neighboring gene uncharacterized LOC107054150 Neighboring gene uncharacterized LOC121111519 Neighboring gene ring finger protein 13 Neighboring gene COMM domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In birds, profilin-2a is ubiquitously expressed and contributes to actin-based motility. Murk K, et al. J Cell Sci, 2009 Apr 1. PMID 19258389
  2. Conserved BK channel-protein interactions reveal signals relevant to cell death and survival. Sokolowski B, et al. PLoS One, 2011. PMID 22174833, Free PMC Article
  3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
profilin-2
Names
profilin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079760.1 → NP_001073228.1  profilin-2

    See identical proteins and their annotated locations for NP_001073228.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ719884
    UniProtKB/TrEMBL
    F1NUH4, Q5ZL50
    Related
    ENSGALP00010001084.1, ENSGALT00010002534.1
    Conserved Domains (1) summary
    smart00392
    Location:2 → 140
    PROF; Profilin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    23459531..23464683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015291695.4 → XP_015147181.1  profilin-2 isoform X1

    Conserved Domains (1) summary
    smart00392
    Location:2 → 139
    PROF; Profilin

  2. XM_025153418.3 → XP_025009186.1  profilin-2 isoform X2

    Conserved Domains (1) summary
    cl00123
    Location:15 → 117
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...

  3. XM_046898481.1 → XP_046754437.1  profilin-2 isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    23244963..23250125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924021.1 → XP_046779977.1  profilin-2 isoform X1

  2. XM_046924022.1 → XP_046779978.1  profilin-2 isoform X2

  3. XM_046924023.1 → XP_046779979.1  profilin-2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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