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Tmem116 transmembrane protein 116 [ Mus musculus (house mouse) ]

Gene ID: 77462, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem116provided by MGI
Official Full Name
transmembrane protein 116provided by MGI
Primary source
MGI:MGI:1924712
See related
Ensembl:ENSMUSG00000029452 AllianceGenome:MGI:1924712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930406A18Rik; 4930513P12Rik; C030022K24Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human TMEM116 (transmembrane protein 116). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 38.8), testis adult (RPKM 10.9) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 61.81 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121590643..121656601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121452580..121518188)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1688 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene STARR-seq mESC enhancer starr_14257 Neighboring gene STARR-positive B cell enhancer ABC_E6373 Neighboring gene STARR-positive B cell enhancer ABC_E6374 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene STARR-positive B cell enhancer ABC_E4785 Neighboring gene mitogen-activated protein kinase 3 pseudogene Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene STARR-positive B cell enhancer ABC_E9092

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway. Zhang S, et al. Cell Death Dis, 2021 Nov 16. PMID 34789718, Free PMC Article
  2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway.
    Title: TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 116

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161626.1 → NP_001155098.1  transmembrane protein 116 isoform 2

    See identical proteins and their annotated locations for NP_001155098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC129215, AK021099, CK127968, DV658154
    Consensus CDS
    CCDS51641.1
    UniProtKB/TrEMBL
    G3X901
    Related
    ENSMUSP00000031405.6, ENSMUST00000031405.12

  2. NM_001161627.1 → NP_001155099.1  transmembrane protein 116 isoform 1

    See identical proteins and their annotated locations for NP_001155099.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC129215, AK021099, CK127968
    Consensus CDS
    CCDS51640.1
    UniProtKB/TrEMBL
    G3X9M9
    Related
    ENSMUSP00000091917.5, ENSMUST00000094357.11

  3. NM_029912.2 → NP_084188.1  transmembrane protein 116 isoform 3

    See identical proteins and their annotated locations for NP_084188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC129215, AK021099, DV658154
    Consensus CDS
    CCDS19635.1
    UniProtKB/TrEMBL
    Q8VCT8
    Related
    ENSMUSP00000054232.9, ENSMUST00000060004.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121590643..121656601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254899.2 → XP_030110759.1  transmembrane protein 116 isoform X4

    UniProtKB/TrEMBL
    Q8CA26
    Related
    ENSMUSP00000121579.4, ENSMUST00000156080.8

  2. XM_036165599.1 → XP_036021492.1  transmembrane protein 116 isoform X3

    UniProtKB/TrEMBL
    Q8VCT8

  3. XM_017321173.2 → XP_017176662.1  transmembrane protein 116 isoform X2

  4. XM_017321172.3 → XP_017176661.1  transmembrane protein 116 isoform X1

  5. XM_017321174.3 → XP_017176663.1  transmembrane protein 116 isoform X3

    UniProtKB/TrEMBL
    Q8VCT8

RNA

  1. XR_001784756.1 RNA Sequence

  2. XR_001784755.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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