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ZMYM2 zinc finger MYM-type containing 2 [ Homo sapiens (human) ]

Gene ID: 7750, updated on 7-Apr-2024

Summary

Official Symbol
ZMYM2provided by HGNC
Official Full Name
zinc finger MYM-type containing 2provided by HGNC
Primary source
HGNC:HGNC:12989
See related
Ensembl:ENSG00000121741 MIM:602221; AllianceGenome:HGNC:12989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIM; MYM; RAMP; SCLL; NECRC; ZNF198
Summary
The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in testis (RPKM 14.1), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

Location:
13q12.11
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (19863840..20089115)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19153836..19285569)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (20531563..20663255)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:20392071-20392598 Neighboring gene zinc finger MYM-type containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20437895-20438623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5142 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20531546-20532088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20532089-20532630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5146 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20533613-20534383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5147 Neighboring gene KRR1 pseudogene 1 Neighboring gene uncharacterized LOC105370101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5148 Neighboring gene long intergenic non-protein coding RNA 1072

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger MYM-type protein 2
Names
fused in myeloproliferative disorders protein
rearranged in an atypical myeloproliferative disorder
zinc finger protein 198
zinc finger, MYM-type 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023348.3 RefSeqGene

    Range
    99889..230277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190964.4NP_001177893.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001177893.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Related
    ENSP00000372327.2, ENST00000382874.6
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  2. NM_001190965.4NP_001177894.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001177894.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  3. NM_001353157.2NP_001340086.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  4. NM_001353159.2NP_001340088.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  5. NM_001353161.3NP_001340090.1  zinc finger MYM-type protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:397437
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11271294
    DUF3504; Domain of unknown function (DUF3504)
  6. NM_001353162.3NP_001340091.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  7. NM_001353163.2NP_001340092.1  zinc finger MYM-type protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  8. NM_001353164.2NP_001340093.1  zinc finger MYM-type protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  9. NM_001353165.2NP_001340094.1  zinc finger MYM-type protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL137119
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (1) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  10. NM_003453.6NP_003444.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_003444.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Related
    ENSP00000372324.2, ENST00000382871.3
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  11. NM_197968.4NP_932072.1  zinc finger MYM-type protein 2 isoform 1

    See identical proteins and their annotated locations for NP_932072.1

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688
    Consensus CDS
    CCDS45016.1
    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Related
    ENSP00000479904.1, ENST00000610343.5
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)

RNA

  1. NR_148365.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137119, AL138688

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    19863840..20089115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430584.1XP_047286540.1  zinc finger MYM-type protein 2 isoform X1

  2. XM_047430585.1XP_047286541.1  zinc finger MYM-type protein 2 isoform X1

  3. XM_047430595.1XP_047286551.1  zinc finger MYM-type protein 2 isoform X5

  4. XM_047430587.1XP_047286543.1  zinc finger MYM-type protein 2 isoform X2

  5. XM_047430594.1XP_047286550.1  zinc finger MYM-type protein 2 isoform X4

  6. XM_024449406.2XP_024305174.1  zinc finger MYM-type protein 2 isoform X2

    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:484524
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:12141381
    DUF3504; Domain of unknown function (DUF3504)
  7. XM_047430593.1XP_047286549.1  zinc finger MYM-type protein 2 isoform X4

  8. XM_017020731.1XP_016876220.1  zinc finger MYM-type protein 2 isoform X5

    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  9. XM_047430592.1XP_047286548.1  zinc finger MYM-type protein 2 isoform X4

  10. XM_047430591.1XP_047286547.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  11. XM_047430599.1XP_047286555.1  zinc finger MYM-type protein 2 isoform X6

  12. XM_024449407.2XP_024305175.1  zinc finger MYM-type protein 2 isoform X7

    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (1) summary
    pfam06467
    Location:484524
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  13. XM_047430602.1XP_047286558.1  zinc finger MYM-type protein 2 isoform X11

  14. XM_047430586.1XP_047286542.1  zinc finger MYM-type protein 2 isoform X2

  15. XM_005266520.4XP_005266577.1  zinc finger MYM-type protein 2 isoform X3

    See identical proteins and their annotated locations for XP_005266577.1

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:462502
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11921359
    DUF3504; Domain of unknown function (DUF3504)
  16. XM_017020732.2XP_016876221.1  zinc finger MYM-type protein 2 isoform X5

    UniProtKB/TrEMBL
    A8K126
    Conserved Domains (2) summary
    pfam06467
    Location:375415
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11051272
    DUF3504; Domain of unknown function (DUF3504)
  17. XM_047430589.1XP_047286545.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  18. XM_047430598.1XP_047286554.1  zinc finger MYM-type protein 2 isoform X5

  19. XM_047430600.1XP_047286556.1  zinc finger MYM-type protein 2 isoform X8

  20. XM_047430601.1XP_047286557.1  zinc finger MYM-type protein 2 isoform X9

  21. XM_047430603.1XP_047286559.1  zinc finger MYM-type protein 2 isoform X12

  22. XM_047430588.1XP_047286544.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  23. XM_047430590.1XP_047286546.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  24. XM_047430597.1XP_047286553.1  zinc finger MYM-type protein 2 isoform X5

  25. XM_047430596.1XP_047286552.1  zinc finger MYM-type protein 2 isoform X5

  26. XM_011535223.3XP_011533525.1  zinc finger MYM-type protein 2 isoform X10

    Conserved Domains (2) summary
    pfam06467
    Location:120160
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:681848
    DUF3504; Domain of unknown function (DUF3504)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    19153836..19285569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374924.1XP_054230899.1  zinc finger MYM-type protein 2 isoform X13

  2. XM_054374936.1XP_054230911.1  zinc finger MYM-type protein 2 isoform X5

  3. XM_054374927.1XP_054230902.1  zinc finger MYM-type protein 2 isoform X2

  4. XM_054374933.1XP_054230908.1  zinc finger MYM-type protein 2 isoform X4

  5. XM_054374925.1XP_054230900.1  zinc finger MYM-type protein 2 isoform X2

  6. XM_054374934.1XP_054230909.1  zinc finger MYM-type protein 2 isoform X4

  7. XM_054374939.1XP_054230914.1  zinc finger MYM-type protein 2 isoform X5

  8. XM_054374932.1XP_054230907.1  zinc finger MYM-type protein 2 isoform X4

  9. XM_054374931.1XP_054230906.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  10. XM_054374940.1XP_054230915.1  zinc finger MYM-type protein 2 isoform X6

  11. XM_054374941.1XP_054230916.1  zinc finger MYM-type protein 2 isoform X7

  12. XM_054374945.1XP_054230920.1  zinc finger MYM-type protein 2 isoform X14

  13. XM_054374946.1XP_054230921.1  zinc finger MYM-type protein 2 isoform X11

  14. XM_054374926.1XP_054230901.1  zinc finger MYM-type protein 2 isoform X2

  15. XM_054374928.1XP_054230903.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  16. XM_054374935.1XP_054230910.1  zinc finger MYM-type protein 2 isoform X5

  17. XM_054374942.1XP_054230917.1  zinc finger MYM-type protein 2 isoform X8

  18. XM_054374943.1XP_054230918.1  zinc finger MYM-type protein 2 isoform X9

  19. XM_054374947.1XP_054230922.1  zinc finger MYM-type protein 2 isoform X12

  20. XM_054374929.1XP_054230904.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  21. XM_054374930.1XP_054230905.1  zinc finger MYM-type protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
  22. XM_054374938.1XP_054230913.1  zinc finger MYM-type protein 2 isoform X5

  23. XM_054374937.1XP_054230912.1  zinc finger MYM-type protein 2 isoform X5

  24. XM_054374944.1XP_054230919.1  zinc finger MYM-type protein 2 isoform X10