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Myh10 myosin, heavy polypeptide 10, non-muscle [ Mus musculus (house mouse) ]

Gene ID: 77579, updated on 13-Jun-2021

Summary

Official Symbol
Myh10provided by MGI
Official Full Name
myosin, heavy polypeptide 10, non-muscleprovided by MGI
Primary source
MGI:MGI:1930780
See related
Ensembl:ENSMUSG00000020900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fl; Fltn; Myhn; NM2B; SMem; Myhn-; Myhn2; NMHC-; SMemb; Myhn-2; NMHC-B; NMMHC-B; NMHCII-B; NMHC II-B; NMMHC-IIB; mKIAA3005; NMMHC II-b; 5730504C04Rik; 9330167F11Rik
Expression
Broad expression in CNS E11.5 (RPKM 43.2), CNS E14 (RPKM 26.8) and 19 other tissues See more
Orthologs
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Genomic context

See Myh10 in Genome Data Viewer
Location:
11 B3; 11 41.95 cM
Exon count:
44
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68581228..68707451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68691915..68816626)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68505417..68630126)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 42 Neighboring gene VISTA enhancer mm213 Neighboring gene uncharacterized LOC118567913 Neighboring gene uncharacterized LOC118567914 Neighboring gene nudE neurodevelopment protein 1 like 1 Neighboring gene ring finger protein 222

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC115764

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATPase ISO
Inferred from Sequence Orthology
more info
 
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin filament bundle distribution ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin filament-based movement ISO
Inferred from Sequence Orthology
more info
 
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fourth ventricle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral ventricle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within substrate-dependent cell migration, cell extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within third ventricle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of myosin II complex ISO
Inferred from Sequence Orthology
more info
 
located_in myosin II filament ISO
Inferred from Sequence Orthology
more info
 
part_of myosin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of polysome ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myosin-10
Names
cellular myosin heavy chain, type B
flectin
myosin IIB
myosin heavy chain 10, non-muscle
myosin heavy chain, non-muscle IIb
myosin heavy chain, nonmuscular, type B
non-muscle myosin heavy chain B
non-muscle myosin heavy chain IIb
nonmuscle myosin heavy chain II-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175260.2NP_780469.1  myosin-10

    See identical proteins and their annotated locations for NP_780469.1

    Status: VALIDATED

    Source sequence(s)
    AK029236, AK147567, CJ100063
    Consensus CDS
    CCDS24869.1
    UniProtKB/Swiss-Prot
    Q61879
    UniProtKB/TrEMBL
    Q3UH59
    Related
    ENSMUSP00000099671.4, ENSMUST00000102611.10
    Conserved Domains (3) summary
    cd14920
    Location:99771
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8481928
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68581228..68707451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157089.1XP_036012982.1  myosin-10 isoform X1

    Conserved Domains (3) summary
    cd14920
    Location:99802
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8791959
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain
  2. XM_036157090.1XP_036012983.1  myosin-10 isoform X4

    Conserved Domains (3) summary
    cd14920
    Location:99771
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8481928
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain
  3. XM_006534489.4XP_006534552.1  myosin-10 isoform X1

    UniProtKB/TrEMBL
    Q5SV64
    Related
    ENSMUSP00000018887.9, ENSMUST00000018887.15
    Conserved Domains (3) summary
    cd14920
    Location:99802
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8791959
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain
  4. XM_017314835.3XP_017170324.1  myosin-10 isoform X3

    Conserved Domains (3) summary
    cd14920
    Location:99781
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8581938
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain
  5. XM_017314834.3XP_017170323.1  myosin-10 isoform X2

    Conserved Domains (3) summary
    cd14920
    Location:99792
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8691949
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain
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