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Bora bora, aurora kinase A activator [ Mus musculus (house mouse) ]

Gene ID: 77744, updated on 5-Mar-2024

Summary

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Official Symbol
Boraprovided by MGI
Official Full Name
bora, aurora kinase A activatorprovided by MGI
Primary source
MGI:MGI:1924994
See related
Ensembl:ENSMUSG00000022070 AllianceGenome:MGI:1924994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720463M24Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in activation of protein kinase activity; regulation of cell cycle process; and regulation of protein localization. Predicted to act upstream of or within cell division. Located in meiotic spindle. Is expressed in alimentary system; brain ventricular layer; cranium; renal cortex; and vibrissa. Orthologous to human BORA (BORA aurora kinase A activator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.9), limb E14.5 (RPKM 6.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 E2.2; 14 49.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (99283880..99311976)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99046377..99074540)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41228 Neighboring gene predicted gene, 18148 Neighboring gene STARR-seq mESC enhancer starr_37423 Neighboring gene ribosomal protein L36A, pseudogene 1 Neighboring gene VISTA enhancer mm829 Neighboring gene STARR-seq mESC enhancer starr_37425 Neighboring gene STARR-positive B cell enhancer ABC_E1902 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5462 Neighboring gene STARR-seq mESC enhancer starr_37426 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene STARR-seq mESC enhancer starr_37427 Neighboring gene STARR-seq mESC enhancer starr_37430 Neighboring gene Kruppel-like transcription factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis. Zhai R, et al. Mol Reprod Dev, 2013 Jun. PMID 23610072
  2. Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Hutterer A, et al. Dev Cell, 2006 Aug. PMID 16890155
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein aurora borealis
Names
aurora borealis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175265.6 → NP_780474.1  protein aurora borealis

    See identical proteins and their annotated locations for NP_780474.1

    Status: VALIDATED

    Source sequence(s)
    AC154843
    Consensus CDS
    CCDS27309.1
    UniProtKB/Swiss-Prot
    Q3TJH7, Q3UWZ8, Q80WQ5, Q8BS90, Q8C8E9
    Related
    ENSMUSP00000022656.7, ENSMUST00000022656.8
    Conserved Domains (1) summary
    pfam15280
    Location:8 → 204
    BORA_N; Protein aurora borealis N-terminus

RNA

  1. NR_153765.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154843
    Related
    ENSMUST00000227744.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    99283880..99311976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519688.4 → XP_006519751.1  protein aurora borealis isoform X1

    Conserved Domains (1) summary
    pfam15280
    Location:27 → 75
    BORA_N; Protein aurora borealis N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BS90.1 GenPept UniProtKB/Swiss-Prot:Q8BS90

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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