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ZNF236 zinc finger protein 236 [ Homo sapiens (human) ]

Gene ID: 7776, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF236provided by HGNC
Official Full Name
zinc finger protein 236provided by HGNC
Primary source
HGNC:HGNC:13028
See related
Ensembl:ENSG00000130856 MIM:604760; AllianceGenome:HGNC:13028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF236A; ZNF236B
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glucose stimulus. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.8), ovary (RPKM 2.3) and 24 other tissues See more
Orthologs
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Genomic context

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See ZNF236 in Genome Data Viewer
Location:
18q23
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (76822557..76972901)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (77051329..77214701)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (74534513..74684857)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904327 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:74503764-74503939 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9558 Neighboring gene ZNF236 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13513 Neighboring gene RNA, U6 small nuclear 346, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13515 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9561 Neighboring gene uncharacterized LOC105372214 Neighboring gene ribosomal protein L26 pseudogene 35 Neighboring gene exportin for tRNA pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74651502-74652002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9562 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74678461-74679129 Neighboring gene uncharacterized LOC105372217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74694849-74695698 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:74700218-74701417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74704741-74705313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74709764-74710264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74710265-74710765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74717425-74718324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74718325-74719223 Neighboring gene myelin basic protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:74748403-74749602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74757338-74757860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74765055-74765555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74766661-74767562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74770546-74771179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13521 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:74776675-74777874 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13524 Neighboring gene uncharacterized LOC124904328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74802305-74802806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:74802807-74803306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:74804211-74804718

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of ZNF236, a glucose-regulated Kruppel-like zinc-finger gene mapping to human chromosome 18q22-q23. Holmes DI, et al. Genomics, 1999 Aug 15. PMID 10458916
  2. The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy. Halama N, et al. Genomics, 2003 Sep. PMID 12906866
  3. Identification of glucose-regulated genes in human mesangial cells by mRNA differential display. Holmes DI, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299475
  4. 14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation. Marzinke MA, et al. Arch Biochem Biophys, 2013 Dec. PMID 24161943, Free PMC Article
  5. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. McDonough CW, et al. Hum Genet, 2009 Dec. PMID 19690890, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 236
Names
regulated by glucose

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306089.2 → NP_001293018.1  zinc finger protein 236 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC027575, AC093330
    Consensus CDS
    CCDS77201.1
    UniProtKB/TrEMBL
    J9JID5
    Related
    ENSP00000322361.9, ENST00000320610.14
    Conserved Domains (5) summary
    COG5048
    Location:197 → 707
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1255 → 1275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1183 → 1207
    zf-H2C2_2; Zinc-finger double domain

  2. NM_007345.4 → NP_031371.3  zinc finger protein 236 isoform 2

    See identical proteins and their annotated locations for NP_031371.3

    Status: REVIEWED

    Source sequence(s)
    AC027575, AC093330
    Consensus CDS
    CCDS42447.1
    UniProtKB/Swiss-Prot
    B2RTX9, Q9UL36, Q9UL37
    Related
    ENSP00000253159.8, ENST00000253159.12
    Conserved Domains (5) summary
    COG5048
    Location:195 → 705
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1253 → 1273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:197 → 219
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1181 → 1205
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    76822557..76972901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526168.3 → XP_011524470.1  zinc finger protein 236 isoform X4

    Conserved Domains (5) summary
    COG5048
    Location:197 → 550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1255 → 1275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1183 → 1207
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011526169.4 → XP_011524471.1  zinc finger protein 236 isoform X5

    Conserved Domains (5) summary
    COG5048
    Location:197 → 550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:201 → 221
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1255 → 1275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:199 → 221
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1183 → 1207
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011526165.4 → XP_011524467.1  zinc finger protein 236 isoform X1

    See identical proteins and their annotated locations for XP_011524467.1

    UniProtKB/Swiss-Prot
    B2RTX9, Q9UL36, Q9UL37
    Conserved Domains (5) summary
    COG5048
    Location:195 → 705
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:199 → 219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1253 → 1273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:197 → 219
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1181 → 1205
    zf-H2C2_2; Zinc-finger double domain

  4. XM_047437793.1 → XP_047293749.1  zinc finger protein 236 isoform X2

  5. XM_011526166.3 → XP_011524468.1  zinc finger protein 236 isoform X3

    UniProtKB/TrEMBL
    Q59HC5
    Conserved Domains (5) summary
    COG5048
    Location:56 → 566
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1114 → 1134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:58 → 80
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:1042 → 1066
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    77051329..77214701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319093.1 → XP_054175068.1  zinc finger protein 236 isoform X6

  2. XM_054319098.1 → XP_054175073.1  zinc finger protein 236 isoform X4

  3. XM_054319099.1 → XP_054175074.1  zinc finger protein 236 isoform X5

  4. XM_054319095.1 → XP_054175070.1  zinc finger protein 236 isoform X1

  5. XM_054319096.1 → XP_054175071.1  zinc finger protein 236 isoform X2

  6. XM_054319094.1 → XP_054175069.1  zinc finger protein 236 isoform X1

  7. XM_054319097.1 → XP_054175072.1  zinc finger protein 236 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UL36.2 GenPept UniProtKB/Swiss-Prot:Q9UL36

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