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nodal transforming growth factor beta superfamily signaling ligand [ Ciona intestinalis (vase tunicate) ]

Gene ID: 778979, updated on 21-Dec-2023

Summary

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Gene symbol
nodal
Gene description
transforming growth factor beta superfamily signaling ligand
See related
Ensembl:ENSCING00000001251
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ciona intestinalis
Lineage
Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia; Cionidae; Ciona
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Genomic context

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See nodal in Genome Data Viewer
Location:
chromosome: Un
Exon count:
4
Annotation release Status Assembly Chr Location
104 current KH (GCF_000224145.3) Unplaced Scaffold NW_004190345.2 (32119..37584)

NW_004190345.2Genomic Context describing neighboring genes Neighboring gene exosome complex component RRP4 Neighboring gene E3 SUMO-protein ligase NSE2 Neighboring gene glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial Neighboring gene uncharacterized LOC100187156 Neighboring gene 39S ribosomal protein L38, mitochondrial-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004190345 Unplaced Scaffold Reference KH Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination. Fiuza UM, et al. Development, 2020 Aug 14. PMID 32665244
  2. Nodal and FGF coordinate ascidian neural tube morphogenesis. Navarrete IA, et al. Development, 2016 Dec 15. PMID 27827820, Free PMC Article
  3. An otx/nodal regulatory signature for posterior neural development in ascidians. Roure A, et al. PLoS Genet, 2014 Aug. PMID 25121599, Free PMC Article
  4. Repression of Rx gene on the left side of the sensory vesicle by Nodal signaling is crucial for right-sided formation of the ocellus photoreceptor in the development of Ciona intestinalis. Yoshida K, et al. Dev Biol, 2011 Jun 1. PMID 21402066
  5. Nodal regulates neural tube formation in the Ciona intestinalis embryo. Mita K, et al. Dev Genes Evol, 2007 Aug. PMID 17624550

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination.
    Title: A Nodal/Eph signalling relay drives the transition from apical constriction to apico-basal shortening in ascidian endoderm invagination.
  2. Nodal and FGF signals control the detailed cellular behaviors underlying morphogenesis of the neural tube. In the absence of FGF and Nodal, neural progenitors exhibit a default behavior of sequential cell divisions, and fail to undergo the intercalary and stacking behaviors essential for normal morphogenesis.
    Title: Nodal and FGF coordinate ascidian neural tube morphogenesis.
  3. Between ascidians and vertebrates, major fate determinants, such as Otx and Nodal, can be co-opted into different networks
    Title: An otx/nodal regulatory signature for posterior neural development in ascidians.
  4. Data show that Ci-Rx, which is essential for the ocellus differentiation, is negatively regulated by the Nodal signaling on the left side of the sensory vesicle.
    Title: Repression of Rx gene on the left side of the sensory vesicle by Nodal signaling is crucial for right-sided formation of the ocellus photoreceptor in the development of Ciona intestinalis.
  5. A regulatory cascade composed of Ci-Nodal, Ci-ZicL, and Ci-Cdx may play an important role in neural tube formation in the Ciona embryo.
    Title: Nodal regulates neural tube formation in the Ciona intestinalis embryo.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables type I activin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transforming growth factor beta superfamily signaling ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001078532.1 → NP_001072000.1  transforming growth factor beta superfamily signaling ligand precursor

    See identical proteins and their annotated locations for NP_001072000.1

    Status: PROVISIONAL

    Source sequence(s)
    AB210585
    UniProtKB/TrEMBL
    A0A1W2VP30, Q4H337
    Related
    ENSCINP00000002425, ENSCINT00000002425
    Conserved Domains (2) summary
    pfam00019
    Location:312 → 414
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:49 → 155
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Ciona intestinalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference KH Primary Assembly

Genomic

  1. NW_004190345.2 Reference KH Primary Assembly

    Range
    32119..37584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026837817.1 → XP_026693618.1  transforming growth factor beta superfamily signaling ligand isoform X1

    UniProtKB/TrEMBL
    F7AEN4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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