Cul9 cullin 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cul9provided by MGI
Official Full Name: cullin 9provided by MGI
Primary source: MGI:MGI:1925559
See related: Ensembl:ENSMUSG00000040327 AllianceGenome:MGI:1925559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Parc; Cul-9; mKIAA0708; 1810035I07Rik
Summary: Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Predicted to be located in cytosol. Predicted to be part of cullin-RING ubiquitin ligase complex. Is expressed in several structures, including brain; retina nuclear layer; and testis. Orthologous to human CUL9 (cullin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 12.3), adrenal adult (RPKM 12.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.9 cM

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46811535..46857314, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46500609..46546388, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.
Title: Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
Title: Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin.
A 3M-CUL9-survivin pathway is implicated in maintaining microtubule and genome integrity, normal development, and tumor suppression.
Title: CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
Dimerization of Cul7 and Parc is not required for all Cul7 functions and mouse development.
Title: Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development.
FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2
Title: Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW049942 (e-PCR)
- UniSTS:181023

AW240594 (e-PCR)
- UniSTS:181028

NoName (e-PCR)
- UniSTS:237655

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cullin-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cullin-9

Names: p53-associated parkin-like cytoplasmic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081335.2 → NP_001074804.2 cullin-9

Status: VALIDATED

Source sequence(s)

AK051474, AK147675, AK162968, BP753198, CF534354, CJ110581

Consensus CDS

CCDS37636.2

UniProtKB/TrEMBL

E9QP09, S4R1Y1

Related

ENSMUSP00000138418.2, ENSMUST00000182485.8

Conserved Domains (7) summary

COG5647
Location:1694 → 1947

COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]

cl02148
Location:1169 → 1299

APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

pfam00888
Location:1597 → 1815

Cullin; Cullin family

pfam11515
Location:367 → 441

Cul7; Mouse development and cellular proliferation protein Cullin-7

cd20347
Location:2150 → 2223

BRcat_RBR_CUL9; BRcat domain found in cullin-9 (CUL-9) and similar proteins

cd20359
Location:2231 → 2288

Rcat_RBR_CUL9; Rcat domain found in cullin-9 (CUL-9) and similar proteins

cl17238
Location:2072 → 2124

RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

46811535..46857314 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246723.4 → XP_011245025.1 cullin-9 isoform X2

UniProtKB/TrEMBL

E9QP09

Conserved Domains (8) summary

smart00647
Location:2183 → 2245

IBR; In Between Ring fingers

COG5647
Location:1732 → 1985

COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]

cd00162
Location:2112 → 2162

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam00888
Location:1736 → 1852

Cullin; Cullin family

pfam01485
Location:2276 → 2311

IBR; IBR domain, a half RING-finger domain

pfam11515
Location:382 → 456

Cul7; Mouse development and cellular proliferation protein Cullin-7

cl02148
Location:1184 → 1314

APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

cl17238
Location:2111 → 2162

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_011246722.4 → XP_011245024.1 cullin-9 isoform X1

UniProtKB/TrEMBL

E9QP09

Conserved Domains (8) summary

smart00647
Location:2187 → 2249

IBR; In Between Ring fingers

COG5647
Location:1736 → 1989

COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]

cd00162
Location:2116 → 2166

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam00888
Location:1740 → 1856

Cullin; Cullin family

pfam01485
Location:2280 → 2315

IBR; IBR domain, a half RING-finger domain

pfam11515
Location:382 → 456

Cul7; Mouse development and cellular proliferation protein Cullin-7

cl02148
Location:1184 → 1314

APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

cl17238
Location:2115 → 2166

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006525135.5 → XP_006525198.1 cullin-9 isoform X3

UniProtKB/TrEMBL

E9QP09

Related

ENSMUST00000182315.8

Conserved Domains (8) summary

smart00647
Location:2160 → 2222

IBR; In Between Ring fingers

COG5647
Location:1709 → 1962

COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]

cd00162
Location:2089 → 2139

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam00888
Location:1612 → 1829

Cullin; Cullin family

pfam01485
Location:2253 → 2288

IBR; IBR domain, a half RING-finger domain

pfam11515
Location:382 → 456

Cul7; Mouse development and cellular proliferation protein Cullin-7

cl02148
Location:1184 → 1314

APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

cl17238
Location:2088 → 2139

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006525136.5 → XP_006525199.1 cullin-9 isoform X4

UniProtKB/TrEMBL

E9QP09

Conserved Domains (8) summary

smart00647
Location:2160 → 2222

IBR; In Between Ring fingers

COG5647
Location:1709 → 1962

COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]

cd00162
Location:2089 → 2139

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam00888
Location:1612 → 1829

Cullin; Cullin family

pfam01485
Location:2253 → 2288

IBR; IBR domain, a half RING-finger domain

pfam11515
Location:382 → 456

Cul7; Mouse development and cellular proliferation protein Cullin-7

cl02148
Location:1184 → 1314

APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

cl17238
Location:2088 → 2139

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain