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Micu3 mitochondrial calcium uptake family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 78506, updated on 11-Apr-2024

Summary

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Official Symbol
Micu3provided by MGI
Official Full Name
mitochondrial calcium uptake family, member 3provided by MGI
Primary source
MGI:MGI:1925756
See related
Ensembl:ENSMUSG00000039478 AllianceGenome:MGI:1925756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Efha2; 2900075B16Rik
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be located in membrane and mitochondrion. Predicted to be integral component of membrane. Predicted to be part of uniplex complex. Orthologous to human MICU3 (mitochondrial calcium uptake family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 8.6), frontal lobe adult (RPKM 5.7) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A4; 8 23.89 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40760394..40841824)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40307438..40388782)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L3 pseudogene Neighboring gene fibroblast growth factor 20 Neighboring gene microRNA 7666 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MICU3 Plays an Important Role in Cardiovascular Function. Puente BN, et al. Circ Res, 2020 Dec 4. PMID 33059536, Free PMC Article
  2. MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake. Patron M, et al. Cell Death Differ, 2019 Jan. PMID 29725115, Free PMC Article
  3. Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients. Singh R, et al. Sci Adv, 2022 Mar 18. PMID 35302860, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction.
    Title: Mitochondrial calcium uptake 3 mitigates cerebral amyloid angiopathy-related neuronal death and glial inflammation by reducing mitochondrial dysfunction.
  2. MICU3 forms a disulfide bond-mediated dimer with MICU1, but not with MICU2, and it acts as enhancer of MCU-dependent mitochondrial Ca(2+) uptake. Silencing of MICU3 in primary cortical neurons impairs Ca(2+) signals elicited by synaptic activity, thus suggesting a specific role in regulating neuronal function.
    Title: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.
  3. MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake
    Title: MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of uniplex complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calcium uptake protein 3, mitochondrial
Names
EF-hand domain family, member A2
EF-hand domain-containing family member A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030110.2 → NP_084386.1  calcium uptake protein 3, mitochondrial

    See identical proteins and their annotated locations for NP_084386.1

    Status: VALIDATED

    Source sequence(s)
    AC102680, AC160537
    Consensus CDS
    CCDS52545.1
    UniProtKB/Swiss-Prot
    Q9CTY5
    Related
    ENSMUSP00000070241.8, ENSMUST00000068999.14
    Conserved Domains (2) summary
    pfam05763
    Location:349 → 437
    DUF835; Protein of unknown function (DUF835)
    pfam13833
    Location:442 → 495
    EF-hand_8; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    40760394..40841824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509522.4 → XP_006509585.1  calcium uptake protein 3, mitochondrial isoform X1

    Conserved Domains (2) summary
    PTZ00183
    Location:231 → 346
    PTZ00183; centrin; Provisional
    cd16175
    Location:229 → 483
    EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins

  2. XM_017313013.3 → XP_017168502.1  calcium uptake protein 3, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0JLX6
    Conserved Domains (1) summary
    cd16175
    Location:60 → 327
    EFh_MICU3; EF-hand, calcium binding motif, found in calcium uptake protein 3, mitochondrial (MICU3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CTY5.2 GenPept UniProtKB/Swiss-Prot:Q9CTY5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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