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Clip4 CAP-GLY domain containing linker protein family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 78785, updated on 23-Jun-2021

Summary

Official Symbol
Clip4provided by MGI
Official Full Name
CAP-GLY domain containing linker protein family, member 4provided by MGI
Primary source
MGI:MGI:1919100
See related
Ensembl:ENSMUSG00000024059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
R; Rsnl2; 1700024K14Rik; 1700074B05Rik; 4833417L20Rik; 5830409B12Rik
Expression
Biased expression in testis adult (RPKM 58.9), heart adult (RPKM 24.2) and 8 other tissues See more
Orthologs
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Genomic context

See Clip4 in Genome Data Viewer
Location:
17; 17 E1.3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (72076674..72171205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71769674..71864210)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (72119031..72207691)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TOG array regulator of axonemal microtubules 2 Neighboring gene photoreceptor cilium actin regulator Neighboring gene predicted gene, 30140 Neighboring gene anaplastic lymphoma kinase Neighboring gene predicted gene, 41613 Neighboring gene budding uninhibited by benzimidazoles 3 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CAP-Gly domain-containing linker protein 4
Names
restin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271483.1NP_001258412.1  CAP-Gly domain-containing linker protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001258412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154458, AK019516
    Consensus CDS
    CCDS89147.1
    Related
    ENSMUSP00000154969.2, ENSMUST00000229874.2
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001271484.1NP_001258413.1  CAP-Gly domain-containing linker protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001258413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK029962, AK161301, AV260889
    Consensus CDS
    CCDS89148.1
    UniProtKB/TrEMBL
    Q3TTL7
    Related
    ENSMUSP00000154878.2, ENSMUST00000230333.2
    Conserved Domains (4) summary
    cd00204
    Location:98252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01302
    Location:487550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
  3. NM_030179.3NP_084455.2  CAP-Gly domain-containing linker protein 4 isoform 1

    See identical proteins and their annotated locations for NP_084455.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154458, AC154569
    Consensus CDS
    CCDS37687.1
    UniProtKB/Swiss-Prot
    Q8CI96
    Related
    ENSMUSP00000024854.8, ENSMUST00000024854.9
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_175378.1NP_780587.1  CAP-Gly domain-containing linker protein 4 isoform 2

    See identical proteins and their annotated locations for NP_780587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154458, AC154569
    Consensus CDS
    CCDS89149.1
    UniProtKB/Swiss-Prot
    Q8CI96
    Related
    ENSMUSP00000155140.2, ENSMUST00000229952.2
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_073185.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains multiple differences compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154458, AK029962
    Related
    ENSMUST00000230747.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    72076674..72171205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250146.2XP_030106006.1  CAP-Gly domain-containing linker protein 4 isoform X2

    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_006525144.4XP_006525207.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525207.1

    UniProtKB/Swiss-Prot
    Q8CI96
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_006525146.1XP_006525209.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525209.1

    UniProtKB/Swiss-Prot
    Q8CI96
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_006525145.5XP_006525208.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525208.1

    UniProtKB/Swiss-Prot
    Q8CI96
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_006525147.5XP_006525210.1  CAP-Gly domain-containing linker protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006525210.1

    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_006525153.4XP_006525216.1  CAP-Gly domain-containing linker protein 4 isoform X7

    See identical proteins and their annotated locations for XP_006525216.1

    Related
    ENSMUSP00000155653.2, ENSMUST00000229304.2
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:285349
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  7. XM_030250147.2XP_030106007.1  CAP-Gly domain-containing linker protein 4 isoform X4

    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  8. XM_006525143.5XP_006525206.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525206.1

    UniProtKB/Swiss-Prot
    Q8CI96
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  9. XM_006525150.4XP_006525213.1  CAP-Gly domain-containing linker protein 4 isoform X5

    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  10. XM_006525151.4XP_006525214.1  CAP-Gly domain-containing linker protein 4 isoform X6

    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:285349
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  11. XM_036160848.1XP_036016741.1  CAP-Gly domain-containing linker protein 4 isoform X7

    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:285349
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  12. XM_006525148.5XP_006525211.1  CAP-Gly domain-containing linker protein 4 isoform X3

    See identical proteins and their annotated locations for XP_006525211.1

    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)
  13. XM_006525154.4XP_006525217.1  CAP-Gly domain-containing linker protein 4 isoform X8

    See identical proteins and their annotated locations for XP_006525217.1

    UniProtKB/Swiss-Prot
    Q8CI96
    Conserved Domains (3) summary
    sd00045
    Location:153184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111217
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_385397.5 RNA Sequence

  2. XR_003952214.2 RNA Sequence

  3. XR_003952215.2 RNA Sequence

  4. XR_001782131.3 RNA Sequence

  5. XR_004939602.1 RNA Sequence

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