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Wsb1 WD repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

Gene ID: 78889, updated on 5-Mar-2024

Summary

Official Symbol
Wsb1provided by MGI
Official Full Name
WD repeat and SOCS box-containing 1provided by MGI
Primary source
MGI:MGI:1926139
See related
Ensembl:ENSMUSG00000017677 AllianceGenome:MGI:1926139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110056B13Rik; 2700038M07Rik
Summary
Enables ubiquitin protein ligase activity. Involved in protein K27-linked ubiquitination. Acts upstream of or within protein aggregate center assembly. Located in cytoplasm. Is expressed in nervous system and neural retina. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 127.9), CNS E14 (RPKM 125.2) and 21 other tissues See more
Orthologs
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Genomic context

Location:
11 B5; 11 46.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79130208..79145521, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79239382..79254709, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5251 Neighboring gene predicted gene 11201 Neighboring gene kinase suppressor of ras 1 Neighboring gene STARR-seq mESC enhancer starr_30109 Neighboring gene STARR-positive B cell enhancer ABC_E5252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78955902-78956103 Neighboring gene STARR-positive B cell enhancer ABC_E10696 Neighboring gene STARR-positive B cell enhancer ABC_E5253 Neighboring gene predicted gene, 30413 Neighboring gene STARR-seq mESC enhancer starr_30112 Neighboring gene predicted gene, 30470 Neighboring gene STARR-seq mESC enhancer starr_30114 Neighboring gene STARR-positive B cell enhancer ABC_E10697 Neighboring gene predicted gene, 30561 Neighboring gene STARR-seq mESC enhancer starr_30117 Neighboring gene neurofibromin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat and SOCS box-containing protein 1
Names
WD-40-repeat-containing protein with a SOCS box 1
WSB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042565.3NP_001036030.1  WD repeat and SOCS box-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001036030.1

    Status: VALIDATED

    Source sequence(s)
    AI644176, AK048511, BG069536
    UniProtKB/TrEMBL
    Q8C841, Q8VE81
    Related
    ENSMUST00000150416.8
    Conserved Domains (3) summary
    sd00039
    Location:1757
    7WD40; WD40 repeat [structural motif]
    cl02533
    Location:140178
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl29593
    Location:1146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_019653.3NP_062627.3  WD repeat and SOCS box-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_062627.3

    Status: VALIDATED

    Source sequence(s)
    AK167394, BB431254, BY097910
    Consensus CDS
    CCDS25118.1
    UniProtKB/Swiss-Prot
    O54927
    UniProtKB/TrEMBL
    Q3TFQ2, Q3TIA1, Q3U7R9, Q7TMU2
    Related
    ENSMUSP00000017821.6, ENSMUST00000017821.12
    Conserved Domains (4) summary
    COG2319
    Location:139382
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:135388
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:174212
    7WD40; WD40 repeat [structural motif]
    cl02533
    Location:382420
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79130208..79145521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157103.1XP_036012996.1  WD repeat and SOCS box-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    Q8C841, Q8VE81
    Conserved Domains (3) summary
    sd00039
    Location:1757
    7WD40; WD40 repeat [structural motif]
    cl02533
    Location:140178
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl29593
    Location:1146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...