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Wrnip1 Werner helicase interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 78903, updated on 23-Jun-2021

Summary

Official Symbol
Wrnip1provided by MGI
Official Full Name
Werner helicase interacting protein 1provided by MGI
Primary source
MGI:MGI:1926153
See related
Ensembl:ENSMUSG00000021400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WH; WHIP; Wrnip; 4833444L21Rik
Expression
Ubiquitous expression in ovary adult (RPKM 30.0), adrenal adult (RPKM 23.1) and 28 other tissues See more
Orthologs
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Genomic context

See Wrnip1 in Genome Data Viewer
Location:
13; 13 A3.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (32986013..33006593)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (32802030..32822610)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (32893899..32914479)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40876 Neighboring gene myosin light chain kinase family, member 4 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA-dependent DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-dependent DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATPase WRNIP1
Names
Werner helicasae interacting protein 1
Werner syndrome homolog interacting protein
werner helicase-interacting protein 1
NP_084491.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030215.3NP_084491.3  ATPase WRNIP1

    See identical proteins and their annotated locations for NP_084491.3

    Status: VALIDATED

    Source sequence(s)
    AK041886, AK167570, AV237237
    Consensus CDS
    CCDS26427.1
    UniProtKB/Swiss-Prot
    Q91XU0
    Related
    ENSMUSP00000021832.7, ENSMUST00000021832.7
    Conserved Domains (5) summary
    cd00009
    Location:235371
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00734
    Location:1740
    ZnF_Rad18; Rad18-like CCHC zinc finger
    PRK13342
    Location:221656
    PRK13342; recombination factor protein RarA; Reviewed
    pfam12002
    Location:507656
    MgsA_C; MgsA AAA+ ATPase C terminal
    pfam16193
    Location:417506
    AAA_assoc_2; AAA C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    32986013..33006593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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