U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Igsf3 immunoglobulin superfamily, member 3 [ Mus musculus (house mouse) ]

Gene ID: 78908, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Igsf3provided by MGI
Official Full Name
immunoglobulin superfamily, member 3provided by MGI
Primary source
MGI:MGI:1926158
See related
Ensembl:ENSMUSG00000042035 AllianceGenome:MGI:1926158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0466; 1700016K10Rik; 2810035F16Rik; 4833439O17Rik
Summary
Predicted to be involved in lacrimal gland development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in dorsal root ganglion; lung; and spinal cord. Human ortholog(s) of this gene implicated in lacrimal duct obstruction. Orthologous to human IGSF3 (immunoglobulin superfamily member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.2), limb E14.5 (RPKM 8.0) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 F2.2; 3 44.3 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (101284306..101370375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101376672..101463060)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08527 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_08529 Neighboring gene STARR-seq mESC enhancer starr_08530 Neighboring gene predicted gene, 32900 Neighboring gene VISTA enhancer mm1505 Neighboring gene STARR-seq mESC enhancer starr_08533 Neighboring gene STARR-seq mESC enhancer starr_08536 Neighboring gene STARR-seq mESC enhancer starr_08538 Neighboring gene STARR-seq mESC enhancer starr_08539 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101298216-101298417 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101301424-101301635 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101306075-101306330 Neighboring gene STARR-seq mESC enhancer starr_08540 Neighboring gene predicted gene, 40109 Neighboring gene predicted gene, 33162

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis. Usardi A, et al. Dev Neurobiol, 2017 Jan. PMID 27328461
  2. Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Penha-Gonçalves C, et al. Diabetes, 2003 Jun. PMID 12765969
  3. Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10. Yamaji K, et al. Biochem Biophys Res Commun, 2005 Jun 3. PMID 15850792
  4. Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression. Pan Y, et al. Sci Rep, 2016 Oct 24. PMID 27775065, Free PMC Article
  5. Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening. Li MZ, et al. Dev Biol, 2006 Apr 15. PMID 16516881

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.
    Title: Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.
  2. IGSF3 is a novel regulator of neuronal morphogenesis that might function through interactions with multiple partners.
    Title: The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lacrimal gland development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
immunoglobulin superfamily member 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404406.1 → NP_001391335.1  immunoglobulin superfamily member 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131184

  2. NM_001404407.1 → NP_001391336.1  immunoglobulin superfamily member 3 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131184
    UniProtKB/TrEMBL
    A0A0A6YX40
    Related
    ENSMUSP00000141823.2, ENSMUST00000195164.2

  3. NM_001404408.1 → NP_001391337.1  immunoglobulin superfamily member 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131184

  4. NM_207205.3 → NP_997088.2  immunoglobulin superfamily member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_997088.2

    Status: VALIDATED

    Source sequence(s)
    AC131184
    Consensus CDS
    CCDS17682.1
    UniProtKB/Swiss-Prot
    A0A4X9, Q6ZQA6, Q7TPV3
    Related
    ENSMUSP00000048900.6, ENSMUST00000043983.11
    Conserved Domains (3) summary
    smart00410
    Location:293 → 389
    IG_like; Immunoglobulin like
    pfam07686
    Location:687 → 784
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:162 → 256
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    101284306..101370375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502343.5 → XP_006502406.1  immunoglobulin superfamily member 3 isoform X1

    See identical proteins and their annotated locations for XP_006502406.1

    UniProtKB/TrEMBL
    A0A0A6YX40
    Conserved Domains (3) summary
    smart00409
    Location:293 → 389
    IG; Immunoglobulin
    pfam07686
    Location:707 → 804
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:162 → 256
    Ig; Immunoglobulin domain

  2. XM_030252915.2 → XP_030108775.1  immunoglobulin superfamily member 3 isoform X3

    UniProtKB/Swiss-Prot
    A0A4X9, Q6ZQA6, Q7TPV3
    Conserved Domains (3) summary
    smart00410
    Location:293 → 389
    IG_like; Immunoglobulin like
    pfam07686
    Location:687 → 784
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:162 → 256
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQA6.2 GenPept UniProtKB/Swiss-Prot:Q6ZQA6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous