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Srd5a1 steroid 5 alpha-reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 78925, updated on 5-Jan-2022

Summary

Official Symbol
Srd5a1provided by MGI
Official Full Name
steroid 5 alpha-reductase 1provided by MGI
Primary source
MGI:MGI:98400
See related
Ensembl:ENSMUSG00000021594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S5AR 1; Srd5a-1; 0610031P22Rik; 4930435F02Rik
Summary
Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Acts upstream of or within androgen biosynthetic process. Predicted to be located in several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in alimentary system; genitourinary system; hypothalamus; and liver. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in bladder adult (RPKM 34.1), ovary adult (RPKM 15.4) and 20 other tissues See more
Orthologs
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Genomic context

See Srd5a1 in Genome Data Viewer
Location:
13 B3; 13 35.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69721568..69759611, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69573449..69611485, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (69712327..69750341, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530095I07 gene Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene Neighboring gene NOL1/NOP2/Sun domain family member 2 Neighboring gene importin 7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
 
enables amide binding ISO
Inferred from Sequence Orthology
more info
 
enables cholestenone 5-alpha-reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within androgen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sex differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Names
SR type 1
type 1 5alpha-reductase
NP_780492.2
XP_006517536.1
XP_006517537.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175283.3NP_780492.2  3-oxo-5-alpha-steroid 4-dehydrogenase 1

    See identical proteins and their annotated locations for NP_780492.2

    Status: VALIDATED

    Source sequence(s)
    BB585840, BC079863
    Consensus CDS
    CCDS26624.1
    UniProtKB/Swiss-Prot
    Q68FF9
    UniProtKB/TrEMBL
    A0A0R4J136
    Related
    ENSMUSP00000089097.6, ENSMUST00000091514.6
    Conserved Domains (1) summary
    pfam02544
    Location:106255
    Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    69721568..69759611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517474.5XP_006517537.1  3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X2

    Conserved Domains (1) summary
    cl21511
    Location:106184
    PEMT; Phospholipid methyltransferase
  2. XM_006517473.5XP_006517536.1  3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X1

    See identical proteins and their annotated locations for XP_006517536.1

    UniProtKB/TrEMBL
    Q8BUR8
    Related
    ENSMUST00000059235.9
    Conserved Domains (1) summary
    cl21511
    Location:106183
    PEMT; Phospholipid methyltransferase
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