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FASTKD3 FAST kinase domains 3 [ Homo sapiens (human) ]

Gene ID: 79072, updated on 4-Jul-2021

Summary

Official Symbol
FASTKD3provided by HGNC
Official Full Name
FAST kinase domains 3provided by HGNC
Primary source
HGNC:HGNC:28758
See related
Ensembl:ENSG00000124279 MIM:617530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in kidney (RPKM 3.9), lymph node (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See FASTKD3 in Genome Data Viewer
Location:
5p15.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (7859159..7869037, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (7859272..7869144, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374646 Neighboring gene adenylate cyclase 2 Neighboring gene chromosome 5 open reading frame 49 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Neighboring gene semaphorin 5A pseudogene Neighboring gene RNA, U1 small nuclear 76, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5297, FLJ23274, MGC142123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
FAST kinase domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033101.1 RefSeqGene

    Range
    5007..14879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024091.4NP_076996.2  FAST kinase domain-containing protein 3, mitochondrial

    See identical proteins and their annotated locations for NP_076996.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the protein.
    Source sequence(s)
    AK026927, BC001295, BP317791, BQ921348, DA297400
    Consensus CDS
    CCDS3873.1
    UniProtKB/Swiss-Prot
    Q14CZ7
    Related
    ENSP00000264669.5, ENST00000264669.10
    Conserved Domains (3) summary
    smart00952
    Location:593650
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:409477
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:493579
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. NR_036553.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) omits the first coding exon, compared to variant 1. The transcript is predicted to be non-coding because the next available AUG does not appear to be in a favorable context and would result in a severely N-terminally truncated protein. Therefore a coding sequence is not annotated.
    Source sequence(s)
    AF161354, AK026927, BC001295, DA297400
  2. NR_073608.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) omits the first coding exon and uses an alternate splice site in a downstream exon, compared to variant 1. The transcript is predicted to be non-coding because the next available AUG does not appear to be in a favorable context and would result in a severely N-terminally truncated protein. Therefore a coding sequence is not annotated.
    Source sequence(s)
    BC001295, BG613096, DA297400
    Related
    ENST00000513658.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    7859159..7869037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714498.1XP_006714561.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006714561.1

    UniProtKB/Swiss-Prot
    Q14CZ7
    Conserved Domains (3) summary
    smart00952
    Location:593650
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:409477
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:493579
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. XR_001742253.1 RNA Sequence

  2. XR_427664.2 RNA Sequence

    Related
    ENST00000507036.1
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