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METTL22 methyltransferase 22, Kin17 lysine [ Homo sapiens (human) ]

Gene ID: 79091, updated on 3-Apr-2024

Summary

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Official Symbol
METTL22provided by HGNC
Official Full Name
methyltransferase 22, Kin17 lysineprovided by HGNC
Primary source
HGNC:HGNC:28368
See related
Ensembl:ENSG00000067365 MIM:615261; AllianceGenome:HGNC:28368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C16orf68
Summary
This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in testis (RPKM 2.7), endometrium (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (8621698..8667274)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (8654289..8706324)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8715555..8743511)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:8566588-8567787 Neighboring gene transmembrane protein 114 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:8602648-8603380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8733020-8733520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8767471-8767972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8767973-8768472 Neighboring gene RNA, 7SL, cytoplasmic 743, pseudogene Neighboring gene 4-aminobutyrate aminotransferase Neighboring gene RNA, U7 small nuclear 63 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin. Cloutier P, et al. J Proteomics, 2014 Apr 4. PMID 24140279
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL22 trimethylates Lys-135 in Kin17
    Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2654, FLJ12433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methyltransferase-like protein 22
Names
LP8272
methyltransferase like 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024109.4 → NP_077014.4  methyltransferase-like protein 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AC007224, AC138420
    Consensus CDS
    CCDS10533.2
    UniProtKB/Swiss-Prot
    B2RD29, D3DUF2, Q6XYB4, Q9BUU2, Q9HA03
    UniProtKB/TrEMBL
    H3BTF5
    Related
    ENSP00000371345.3, ENST00000381920.8
    Conserved Domains (1) summary
    cl17173
    Location:164 → 337
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_134608.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant (2) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007224, AC138420

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    8621698..8667274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023660.2 → XP_016879149.1  methyltransferase-like protein 22 isoform X2

  2. XM_047434610.1 → XP_047290566.1  methyltransferase-like protein 22 isoform X1

  3. XM_017023659.3 → XP_016879148.1  methyltransferase-like protein 22 isoform X2

  4. XM_047434613.1 → XP_047290569.1  methyltransferase-like protein 22 isoform X4

    UniProtKB/Swiss-Prot
    B2RD29, D3DUF2, Q6XYB4, Q9BUU2, Q9HA03

  5. XM_047434612.1 → XP_047290568.1  methyltransferase-like protein 22 isoform X4

    UniProtKB/Swiss-Prot
    B2RD29, D3DUF2, Q6XYB4, Q9BUU2, Q9HA03

  6. XM_047434614.1 → XP_047290570.1  methyltransferase-like protein 22 isoform X6

  7. XM_005255571.4 → XP_005255628.1  methyltransferase-like protein 22 isoform X6

    UniProtKB/TrEMBL
    H3BTF5
    Conserved Domains (1) summary
    cl17173
    Location:164 → 338
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  8. XM_047434611.1 → XP_047290567.1  methyltransferase-like protein 22 isoform X3

  9. XM_005255570.5 → XP_005255627.1  methyltransferase-like protein 22 isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:164 → 337
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  10. XM_024450439.2 → XP_024306207.1  methyltransferase-like protein 22 isoform X5

    Conserved Domains (1) summary
    cl17173
    Location:164 → 320
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  11. XM_047434615.1 → XP_047290571.1  methyltransferase-like protein 22 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    8654289..8706324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313894.1 → XP_054169869.1  methyltransferase-like protein 22 isoform X8

  2. XM_054313897.1 → XP_054169872.1  methyltransferase-like protein 22 isoform X2

  3. XM_054313895.1 → XP_054169870.1  methyltransferase-like protein 22 isoform X1

  4. XM_054313896.1 → XP_054169871.1  methyltransferase-like protein 22 isoform X2

  5. XM_054313901.1 → XP_054169876.1  methyltransferase-like protein 22 isoform X4

  6. XM_054313900.1 → XP_054169875.1  methyltransferase-like protein 22 isoform X4

  7. XM_054313904.1 → XP_054169879.1  methyltransferase-like protein 22 isoform X6

  8. XM_054313903.1 → XP_054169878.1  methyltransferase-like protein 22 isoform X6

  9. XM_054313899.1 → XP_054169874.1  methyltransferase-like protein 22 isoform X9

  10. XM_054313898.1 → XP_054169873.1  methyltransferase-like protein 22 isoform X9

  11. XM_054313902.1 → XP_054169877.1  methyltransferase-like protein 22 isoform X5

  12. XM_054313905.1 → XP_054169880.1  methyltransferase-like protein 22 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BUU2.2 GenPept UniProtKB/Swiss-Prot:Q9BUU2

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