Fabp3 fatty acid binding protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fabp3provided by RGD
Official Full Name: fatty acid binding protein 3provided by RGD
Primary source: RGD:69048
See related: Ensembl:ENSRNOG00000012879 AllianceGenome:RGD:69048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables icosatetraenoic acid binding activity and long-chain fatty acid transporter activity. Involved in several processes, including long-chain fatty acid transport; response to fatty acid; and response to insulin. Located in cytosol and sarcoplasm. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human FABP3 (fatty acid binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 22480.0), Muscle (RPKM 4643.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (147936027..147942870)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (142651962..142658707)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (148528854..148535597)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
Title: Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP.
Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats via Urotensin II and FABP3 Expressions.
Title: Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats via Urotensin II and FABP3 Expressions.
Skin Ultrastructure and the Changes of HIF-2alpha, H-FABP Expression in the Myocardium of Electric Shock Death Rats.
Title: Skin Ultrastructure and the Changes of HIF-2α, H-FABP Expression in the Myocardium of Electric Shock Death Rats.
Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming
Title: Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming.
Significant down-regulation of heart-type fatty acid binding protein after myocardial ischemia might play an important role in myocardial injury and energy metabolism disorder.
Title: [Heart-type fatty acid-binding protein alteration in rat's cardiocyte after acute myocardial infarction].
H-FABP might have potential to be an early and quantitative parameter of clinical severity and prognosis in CO poisoning.
Title: The role of heart-type fatty acid-binding protein in the evaluation of carbon monoxide poisoning in rats.
A complex interrelationship between glucose and fatty acids in the control of FABP gene expression; FABP3 and 5 may play a role in insulin secretion.
Title: Expression of fatty acid binding proteins 3 and 5 genes in rat pancreatic islets and INS-1E cells: regulation by fatty acids and glucose.
rat myocardial FABP gene maps to chromosome 5q36 and was detected in a preparation of total RNA isolated from adult rat heart
Title: Structure and chromosomal location of the rat gene encoding the heart fatty acid-binding protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94406 (e-PCR)
- UniSTS:119654

RH134427 (e-PCR)
- UniSTS:217707

Fabp3 (e-PCR), detects polymorphism
- UniSTS:498376

RH129910 (e-PCR)
- UniSTS:213198

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables fatty acid binding	TAS Traceable Author Statement more info	PubMed
enables icosatetraenoic acid binding	IPI Inferred from Physical Interaction more info	PubMed
enables long-chain fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acid binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	IPI Inferred from Physical Interaction more info	PubMed
enables oleic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	NAS Non-traceable Author Statement more info	PubMed
involved_in fatty acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular lipid transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular lipid transport	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in long-chain fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-chain fatty acid import into cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid oxidation	IEA Inferred from Electronic Annotation more info
involved_in regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fatty acid-binding protein, heart

Names: Fatty acid binding protein 3 heart; H-FABP; fatty acid binding protein 3, muscle and heart; heart fatty acid binding protein; heart-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.