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mhc1zba major histocompatibility complex class I ZBA [ Danio rerio (zebrafish) ]

Gene ID: 791453, updated on 27-Mar-2024

Summary

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Official Symbol
mhc1zbaprovided by ZNC
Official Full Name
major histocompatibility complex class I ZBAprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2149
See related
Ensembl:ENSDARG00000036588 AllianceGenome:ZFIN:ZDB-GENE-040426-2149
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hlazel; zgc:64115
Summary
Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in gill; intestine; kidney; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to several human genes including AZGP1 (alpha-2-glycoprotein 1, zinc-binding); HFE (homeostatic iron regulator); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (47155424..47161996, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (46464192..46470764, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex class I ZDA Neighboring gene major histocompatibility complex class I ZCA Neighboring gene uncharacterized LOC103909196 Neighboring gene carbonyl reductase 1 Neighboring gene MORC family CW-type zinc finger 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptome Analysis Reveals Increases in Visceral Lipogenesis and Storage and Activation of the Antigen Processing and Presentation Pathway during the Mouth-Opening Stage in Zebrafish Larvae. Xu H, et al. Int J Mol Sci, 2017 Jul 31. PMID 28758957, Free PMC Article
  2. Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Bouwmeester MC, et al. Toxicol Appl Pharmacol, 2016 Jan 15. PMID 26712470
  3. Characterization of novel zebrafish MHC class I U lineage genes and their haplotype. Honjo Y, et al. Dev Comp Immunol, 2021 Mar. PMID 33279476
  4. Characterization of the Z lineage Major histocompatability complex class I genes in zebrafish. Dirscherl H, et al. Immunogenetics, 2014 Mar. PMID 24287892, Free PMC Article
  5. Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. McConnell SC, et al. Immunogenetics, 2014 Mar. PMID 24291825, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC64115, MGC174526

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major histocompatibility complex class I ZBA
Names
MHC class I antigen ZBA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110118.1 → NP_001103588.1  major histocompatibility complex class I ZBA precursor

    See identical proteins and their annotated locations for NP_001103588.1

    Status: PROVISIONAL

    Source sequence(s)
    BX005416
    UniProtKB/TrEMBL
    A8E7F4, A8KC24
    Related
    ENSDARP00000053152.4, ENSDART00000053153.6
    Conserved Domains (2) summary
    cd07698
    Location:209 → 304
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:22 → 205
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    47155424..47161996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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