slco2b1 solute carrier organic anion transporter family, member 2B1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slco2b1provided by ZNC
Official Full Name: solute carrier organic anion transporter family, member 2B1provided by ZNC
Primary source: ZFIN:ZDB-GENE-051023-6
See related: Ensembl:ENSDARG00000054609 AllianceGenome:ZFIN:ZDB-GENE-051023-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7158298; wu:fi40d02; zgc:123236
Summary: Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-independent organic anion transport. Predicted to act upstream of or within ion transport and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gill; liver; pleuroperitoneal region; skeletal muscle; and ventral mesenchyme. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (40140515..40209159, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (40116962..40151123, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish (Danio rerio) Oatp2b1 as a functional ortholog of the human OATP2B1 transporter.
Title: Zebrafish (Danio rerio) Oatp2b1 as a functional ortholog of the human OATP2B1 transporter.

Submit: New GeneRIF Correction

General gene information

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Markers

fi40d02.x1 (e-PCR)
- UniSTS:204591

G45821 (e-PCR)
- UniSTS:106623

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 2B1

Names: Oatp2b1; solute carrier anion transporting family member 2b1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037678.2 → NP_001032767.2 solute carrier organic anion transporter family member 2B1

See identical proteins and their annotated locations for NP_001032767.2

Status: VALIDATED

Source sequence(s)

BX248108, CU104696

UniProtKB/TrEMBL

A0A8N7XJB7, F1Q4Y9, F1Q5M5

Related

ENSDARP00000071311.6, ENSDART00000076840.7

Conserved Domains (1) summary

pfam03137
Location:27 → 591

OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

40140515..40209159 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468920.1 → XP_021324595.1 solute carrier organic anion transporter family member 2B1 isoform X1

UniProtKB/TrEMBL

A0A8N7XJB7, F1Q4Y9, F1Q5M5

Conserved Domains (1) summary

pfam03137
Location:27 → 591

OATP; Organic Anion Transporter Polypeptide (OATP) family