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ZNF557 zinc finger protein 557 [ Homo sapiens (human) ]

Gene ID: 79230, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF557provided by HGNC
Official Full Name
zinc finger protein 557provided by HGNC
Primary source
HGNC:HGNC:28632
See related
Ensembl:ENSG00000130544 AllianceGenome:HGNC:28632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 1.5), thyroid (RPKM 1.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF557 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7069703..7087968)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7060474..7078726)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7069714..7087979)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene methyl-CpG binding domain protein 3 like 2 Neighboring gene methyl-CpG binding domain protein 3 like 3 Neighboring gene MPRA-validated peak3311 silencer Neighboring gene MPRA-validated peak3312 silencer Neighboring gene MPRA-validated peak3313 silencer Neighboring gene uncharacterized LOC124904625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7102509-7103010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7103011-7103510 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:7109747-7110266 Neighboring gene MPRA-validated peak3314 silencer Neighboring gene insulin receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13872 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:7197359-7198195 Neighboring gene uncharacterized LOC124904626

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. Ozyildirim AM, et al. Invest Ophthalmol Vis Sci, 2005 May. PMID 15851553
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  3. Phospho-tyrosine dependent protein-protein interaction network. Grossmann A, et al. Mol Syst Biol, 2015 Mar 26. PMID 25814554, Free PMC Article
  4. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  5. Functional proteomics mapping of a human signaling pathway. Colland F, et al. Genome Res, 2004 Jul. PMID 15231748, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4054, FLJ96454

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 557
Names
CTB-25J19.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044387.2 → NP_001037852.1  zinc finger protein 557 isoform a

    See identical proteins and their annotated locations for NP_001037852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC010606, BC003020, CD723611
    Consensus CDS
    CCDS42485.1
    UniProtKB/Swiss-Prot
    Q8N988
    Conserved Domains (6) summary
    smart00349
    Location:43 → 100
    KRAB; krueppel associated box
    COG5048
    Location:137 → 422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320 → 342
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:43 → 82
    KRAB; KRAB box
    pfam13465
    Location:334 → 359
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001044388.2 → NP_001037853.1  zinc finger protein 557 isoform b

    See identical proteins and their annotated locations for NP_001037853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.
    Source sequence(s)
    AC010606, BC003020, CD723611
    Consensus CDS
    CCDS45945.1
    UniProtKB/Swiss-Prot
    Q6PEJ3, Q8N988, Q9BTZ1
    Related
    ENSP00000404065.2, ENST00000414706.2
    Conserved Domains (6) summary
    smart00349
    Location:36 → 93
    KRAB; krueppel associated box
    COG5048
    Location:130 → 415
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:313 → 335
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:36 → 75
    KRAB; KRAB box
    pfam13465
    Location:327 → 352
    zf-H2C2_2; Zinc-finger double domain

  3. NM_024341.3 → NP_077317.2  zinc finger protein 557 isoform a

    See identical proteins and their annotated locations for NP_077317.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform a). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010606, BC003020, CD723611
    Consensus CDS
    CCDS42485.1
    UniProtKB/Swiss-Prot
    Q8N988
    Related
    ENSP00000252840.5, ENST00000252840.11
    Conserved Domains (6) summary
    smart00349
    Location:43 → 100
    KRAB; krueppel associated box
    COG5048
    Location:137 → 422
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:182 → 202
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:320 → 342
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:43 → 82
    KRAB; KRAB box
    pfam13465
    Location:334 → 359
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7069703..7087968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439432.1 → XP_047295388.1  zinc finger protein 557 isoform X1

    UniProtKB/Swiss-Prot
    Q6PEJ3, Q8N988, Q9BTZ1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7060474..7078726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322143.1 → XP_054178118.1  zinc finger protein 557 isoform X1

    UniProtKB/Swiss-Prot
    Q6PEJ3, Q8N988, Q9BTZ1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N988.2 GenPept UniProtKB/Swiss-Prot:Q8N988

Gene LinkOut

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