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HMGN5 high mobility group nucleosome binding domain 5 [ Homo sapiens (human) ]

Gene ID: 79366, updated on 5-Mar-2024

Summary

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Official Symbol
HMGN5provided by HGNC
Official Full Name
high mobility group nucleosome binding domain 5provided by HGNC
Primary source
HGNC:HGNC:8013
See related
Ensembl:ENSG00000198157 MIM:300385; AllianceGenome:HGNC:8013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSBP1; NBP-45
Summary
This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009]
Expression
Broad expression in testis (RPKM 20.5), adrenal (RPKM 4.3) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
Xq21.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (81113699..81201913, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (79547434..79635633, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (80369198..80457412, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 995, pseudogene Neighboring gene voltage dependent anion channel 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29793 Neighboring gene NANOG hESC enhancer GRCh37_chrX:80482201-80482731 Neighboring gene SH3 domain binding glutamate rich protein like Neighboring gene ReSE screen-validated silencer GRCh37_chrX:80513135-80513400 Neighboring gene uncharacterized LOC124905203

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells. Ma Q, et al. Biomed Res Int, 2020. PMID 32596388, Free PMC Article
  2. HMGN5 expression in bladder cancer tissue and its role on prognosis. Wu J, et al. Eur Rev Med Pharmacol Sci, 2018 Feb. PMID 29509244
  3. Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma. Liu X, et al. J Biochem Mol Toxicol, 2017 Dec. PMID 28914995
  4. HMGN5 blockade by siRNA enhances apoptosis, suppresses invasion and increases chemosensitivity to temozolomide in meningiomas. He J, et al. Int J Oncol, 2015 Oct. PMID 26315299
  5. Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo. Gan Y, et al. Med Oncol, 2015 Apr. PMID 25796505

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.
    Title: Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.
  2. Prognostic value of HMGN family expression in acute myeloid leukemia.
    Title: Prognostic value of HMGN family expression in acute myeloid leukemia.
  3. HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway.
    Title: HMGN5 promotes invasion and migration of colorectal cancer through activating FGF/FGFR pathway.
  4. HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells.
    Title: HMGN5 Silencing Suppresses Cell Biological Progression via AKT/MAPK Pathway in Human Glioblastoma Cells.
  5. HIF1A upregulated the transcription factor GATA1 and further promoted the expression of HMGN5.
    Title: Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis.
  6. HMGN5 mRNA levels were significantly elevated in bladder transitional cell carcinoma tissue compared to controls.
    Title: HMGN5 expression in bladder cancer tissue and its role on prognosis.
  7. MiR-183-3p regulated HMGN5 expression in prostate cancer cells.
    Title: microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5.
  8. Findings suggest that a miR-140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma. In conclusion, our data elucidated that miR-140-5p promoted autophagy mediated by HMGN5 and sensitized osteosarcoma cells to chemotherapy.
    Title: MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy.
  9. High HMGN5 expression is associated with osteosarcoma invasion.
    Title: Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5.
  10. We observed decreased miR-409-3p expression in glioma, and overexpression of miR-409-3p repressed glioma cell invasion and proliferation by targeting HMGN5, an oncogene associated with glioma
    Title: MicroRNA-409-3p Represses Glioma Cell Invasion and Proliferation by Targeting High-Mobility Group Nucleosome-Binding Domain 5.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables chromatin binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables nucleosomal DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
high mobility group nucleosome-binding domain-containing protein 5
Names
nucleosomal binding protein 1
nucleosome-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013234.1 RefSeqGene

    Range
    5030..93244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030763.3 → NP_110390.1  high mobility group nucleosome-binding domain-containing protein 5

    See identical proteins and their annotated locations for NP_110390.1

    Status: REVIEWED

    Source sequence(s)
    AF250329, AK094058, AL391294, DA745749
    Consensus CDS
    CCDS14448.1
    UniProtKB/Swiss-Prot
    P82970, Q5JSL1
    Related
    ENSP00000350848.2, ENST00000358130.7
    Conserved Domains (2) summary
    pfam01101
    Location:1 → 93
    HMG14_17; HMG14 and HMG17
    cl27511
    Location:61 → 281
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    81113699..81201913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442514.1 → XP_047298470.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

  2. XM_047442510.1 → XP_047298466.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X1

  3. XM_047442515.1 → XP_047298471.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X4

  4. XM_047442513.1 → XP_047298469.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

  5. XM_047442512.1 → XP_047298468.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X2

  6. XM_047442511.1 → XP_047298467.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    79547434..79635633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327867.1 → XP_054183842.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

  2. XM_054327864.1 → XP_054183839.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X1

  3. XM_054327866.1 → XP_054183841.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X3

  4. XM_054327868.1 → XP_054183843.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X4

  5. XM_054327865.1 → XP_054183840.1  high mobility group nucleosome-binding domain-containing protein 5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82970.1 GenPept UniProtKB/Swiss-Prot:P82970

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