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Myh10 myosin heavy chain 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79433, updated on 8-Jul-2021

Summary

Official Symbol
Myh10provided by RGD
Official Full Name
myosin heavy chain 10provided by RGD
Primary source
RGD:71000
See related
Ensembl:ENSRNOG00000002886
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MCH-B; SMemb; NMMHC-B
Summary
nonmuscle myosin II heavy chain: produces motor activity with actin filaments; isoform B2 may play a role in neuronal cell motility [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 265.9), Brain (RPKM 225.3) and 9 other tissues See more
Orthologs
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Genomic context

See Myh10 in Genome Data Viewer
Location:
10q24
Exon count:
44
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53393901..53525174)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55274910..55406738)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 42 Neighboring gene similar to microfibrillar-associated protein 1 Neighboring gene 60S ribosomal protein L30-like Neighboring gene nudE neurodevelopment protein 1-like 1 Neighboring gene peroxiredoxin-6-like Neighboring gene ring finger protein 222

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA stem-loop binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA stem-loop binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament bundle distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within actin filament-based movement ISO
Inferred from Sequence Orthology
more info
 
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
 
involved_in actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aorta development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac myofibril assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac septum development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within coronary vasculature development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fourth ventricle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lateral ventricle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myofibril assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within substrate-dependent cell migration, cell extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within third ventricle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actomyosin ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IEA
Inferred from Electronic Annotation
more info
 
part_of myosin II complex ISO
Inferred from Sequence Orthology
more info
 
located_in myosin II filament IEA
Inferred from Electronic Annotation
more info
 
located_in myosin II filament ISO
Inferred from Sequence Orthology
more info
 
part_of myosin complex ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
part_of polysome IEA
Inferred from Electronic Annotation
more info
 
part_of polysome ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myosin-10
Names
MCH-B(B2)
NMMHC II-b
NMMHC-IIB
cellular myosin heavy chain, type B
myosin heavy chain, non-muscle IIb
myosin heavy chain, nonmuscle type B
myosin, heavy chain 10, non-muscle
myosin, heavy polypeptide 10, non-muscle
non-muscle myosin heavy chain B
non-muscle myosin heavy chain IIb
nonmuscle myosin heavy chain IIB
nonmuscle myosin heavy chain-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031520.2NP_113708.2  myosin-10

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    Related
    ENSRNOP00000062744.1, ENSRNOT00000065895.1
    Conserved Domains (3) summary
    cd14920
    Location:99771
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8481928
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    53393901..53525174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597544.2XP_017453033.1  myosin-10 isoform X1

    Conserved Domains (10) summary
    cd14920
    Location:99802
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:87802
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8791959
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16311641
    GBP_C; coiled coil [structural motif]
    cl19511
    Location:11421253
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
    cl19818
    Location:16761727
    DUF106; Integral membrane protein DUF106
    cl20817
    Location:15351641
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21509
    Location:12241371
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl24005
    Location:18001898
    DUF2570; Protein of unknown function (DUF2570)
  2. XM_008767881.3XP_008766103.1  myosin-10 isoform X1

    Conserved Domains (10) summary
    cd14920
    Location:99802
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:87802
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8791959
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16311641
    GBP_C; coiled coil [structural motif]
    cl19511
    Location:11421253
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
    cl19818
    Location:16761727
    DUF106; Integral membrane protein DUF106
    cl20817
    Location:15351641
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21509
    Location:12241371
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl24005
    Location:18001898
    DUF2570; Protein of unknown function (DUF2570)
  3. XM_006246821.4XP_006246883.1  myosin-10 isoform X2

    See identical proteins and their annotated locations for XP_006246883.1

    Conserved Domains (10) summary
    cd14920
    Location:99792
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam00063
    Location:87792
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8691949
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3472
    Myosin_N; Myosin N-terminal SH3-like domain
    cd16269
    Location:16211631
    GBP_C; coiled coil [structural motif]
    cl19511
    Location:11321243
    DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
    cl19818
    Location:16661717
    DUF106; Integral membrane protein DUF106
    cl20817
    Location:15251631
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21509
    Location:12141361
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl24005
    Location:17901888
    DUF2570; Protein of unknown function (DUF2570)
  4. XM_039086920.1XP_038942848.1  myosin-10 isoform X3

    Conserved Domains (3) summary
    cd14920
    Location:99781
    MYSc_Myh10; class II myosin heavy chain 10, motor domain
    pfam01576
    Location:8581938
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3372
    Myosin_N; Myosin N-terminal SH3-like domain
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