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CEP97 centrosomal protein 97 [ Homo sapiens (human) ]

Gene ID: 79598, updated on 3-Apr-2024

Summary

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Official Symbol
CEP97provided by HGNC
Official Full Name
centrosomal protein 97provided by HGNC
Primary source
HGNC:HGNC:26244
See related
Ensembl:ENSG00000182504 MIM:615864; AllianceGenome:HGNC:26244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRIQ2; 2810403B08Rik
Summary
Predicted to enable calmodulin binding activity. Involved in negative regulation of cilium assembly and regulation of mitotic spindle assembly. Located in centriolar satellite and cytosol. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression
Ubiquitous expression in testis (RPKM 4.1), brain (RPKM 4.0) and 24 other tissues See more
Orthologs
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Genomic context

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See CEP97 in Genome Data Viewer
Location:
3q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (101724614..101770562)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (104437398..104483348)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101443458..101489406)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20178 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:101444325-101444936 Neighboring gene PDCL3 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20179 Neighboring gene Sharpr-MPRA regulatory region 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20180 Neighboring gene neurexophilin and PC-esterase domain family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20184 Neighboring gene Sharpr-MPRA regulatory region 1067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20185 Neighboring gene Sharpr-MPRA regulatory region 7874 Neighboring gene NFKB inhibitor zeta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20186 Neighboring gene MPRA-validated peak4754 silencer Neighboring gene RIG-I dependent antiviral response regulator RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20187

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Double life of centrioles: CP110 in the spotlight. Bettencourt-Dias M, et al. Trends Cell Biol, 2008 Jan. PMID 18068367
  2. Cep76, a centrosomal protein that specifically restrains centriole reduplication. Tsang WY, et al. Dev Cell, 2009 May. PMID 19460342, Free PMC Article
  3. Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. Kobayashi T, et al. Cell, 2011 Jun 10. PMID 21620453
  4. Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres. Li J, et al. EMBO Rep, 2012 Jun 1. PMID 22441691, Free PMC Article
  5. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Huang N, et al. Nat Commun, 2018 Oct 30. PMID 30375385, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23047, FLJ26462

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein of 97 kDa
Names
leucine-rich repeat and IQ domain-containing protein 2
leucine-rich repeats and IQ motif containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303401.2 → NP_001290330.1  centrosomal protein of 97 kDa isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC084198, AK294784, BC041085, DA520309
    Consensus CDS
    CCDS77780.1
    UniProtKB/TrEMBL
    B4DGU8, E9PG22
    Related
    ENSP00000418185.1, ENST00000494050.5
    Conserved Domains (4) summary
    cd00116
    Location:78 → 200
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:17 → 37
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:124 → 161
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:103 → 156
    LRR_8; Leucine rich repeat

  2. NM_001410784.1 → NP_001397713.1  centrosomal protein of 97 kDa isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084198
    Consensus CDS
    CCDS93335.1
    UniProtKB/TrEMBL
    A0A994J4L0
    Related
    ENSP00000515874.1, ENST00000704366.1

  3. NM_001410785.1 → NP_001397714.1  centrosomal protein of 97 kDa isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC084198
    Consensus CDS
    CCDS93336.1
    UniProtKB/TrEMBL
    A0A994J7E5
    Related
    ENSP00000515875.1, ENST00000704367.1

  4. NM_024548.4 → NP_078824.2  centrosomal protein of 97 kDa isoform 1

    See identical proteins and their annotated locations for NP_078824.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC084198, BC041085, DA520309
    Consensus CDS
    CCDS2944.1
    UniProtKB/Swiss-Prot
    B5MDY8, Q8IW35, Q8NA71, Q9H5T9
    UniProtKB/TrEMBL
    A0A994J704
    Related
    ENSP00000342510.3, ENST00000341893.8
    Conserved Domains (4) summary
    cd00116
    Location:78 → 200
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:17 → 37
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:124 → 161
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:103 → 156
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    101724614..101770562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448917.1 → XP_047304873.1  centrosomal protein of 97 kDa isoform X1

    UniProtKB/TrEMBL
    A0A994J522
    Related
    ENSP00000515897.1, ENST00000704445.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    104437398..104483348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347858.1 → XP_054203833.1  centrosomal protein of 97 kDa isoform X1

    UniProtKB/TrEMBL
    A0A994J522
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IW35.1 GenPept UniProtKB/Swiss-Prot:Q8IW35

Gene LinkOut

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