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HMBOX1 homeobox containing 1 [ Homo sapiens (human) ]

Gene ID: 79618, updated on 3-Apr-2024

Summary

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Official Symbol
HMBOX1provided by HGNC
Official Full Name
homeobox containing 1provided by HGNC
Primary source
HGNC:HGNC:26137
See related
Ensembl:ENSG00000147421 MIM:618610; AllianceGenome:HGNC:26137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOT1; TAH1; PBHNF; HNF1LA
Summary
Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of telomerase activity; and positive regulation of telomere maintenance via telomerase. Located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 3.8), testis (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

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See HMBOX1 in Genome Data Viewer
Location:
8p21.1-p12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (28890116..29053270)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (29168300..29331436)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28747912..28910787)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:28647439-28647939 Neighboring gene integrator complex subunit 9 Neighboring gene ribosomal protein L36a pseudogene 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19066 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:28728271-28728917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:28747269-28747825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:28747826-28748382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27176 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:28834820-28835748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27177 Neighboring gene uncharacterized LOC105379346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:28913988-28915187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27179 Neighboring gene Sharpr-MPRA regulatory region 8281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28924055-28924554 Neighboring gene RNA, 5S ribosomal pseudogene 260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28927814-28928543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932443-28932946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932947-28933448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28937642-28938205 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28945064-28945235 Neighboring gene kinesin family member 13B Neighboring gene MPRA-validated peak6973 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:29063474-29063627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27183 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19069 Neighboring gene uncharacterized LOC124901922 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene uncharacterized LOC124901923

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone attenuates LPS-induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction. Yuan HX, et al. J Cell Mol Med, 2019 Jan. PMID 30358079, Free PMC Article
  2. Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape. Zhao H, et al. Oncol Rep, 2018 Sep. PMID 30015890
  3. Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis. Yu YL, et al. Biochem Biophys Res Commun, 2018 Jun 22. PMID 29709478
  4. Homeobox‑containing protein 1 loss is associated with clinicopathological performance in glioma. Zhang P, et al. Mol Med Rep, 2017 Oct. PMID 28731165
  5. Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening. Zhou S, et al. Oncol Rep, 2017 Jul. PMID 28628186

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.
    Title: Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.
  2. TDD activates HMBOX1.
    Title: 5,2'-dibromo-2,4',5'-trihydroxydiphenylmethanone attenuates LPS-induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction.
  3. The association of HMBOX1 and CD133 with gastric neoplasm cell proliferation and migration are reported; the use of the levels of these proteins as prognostic markers are discussed.
    Title: High expression of HMBOX1 contributes to poor prognosis of gastric cancer by promoting cell proliferation and migration.
  4. HMBOX1 in hepatocytes acts as a key immunosuppressive factor for inflammation
    Title: HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation.
  5. this study demonstrates for the first time that c-Fos/miR-18a/HMBOX1 axis plays a critical role in the progression of gliomas
    Title: c-Fos/microRNA-18a feedback loop modulates the tumor growth via HMBOX1 in human gliomas.
  6. Low HMBOX1 expression is associated with liver cancer progression.
    Title: Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape.
  7. HMBOX1 played important role in the high-grade serous ovarian cancer through regulation of proliferation and apoptosis.
    Title: Low expression level of HMBOX1 in high-grade serous ovarian cancer accelerates cell proliferation by inhibiting cell apoptosis.
  8. HMBOX1 may be a potential diagnostic marker in glioma.
    Title: Homeobox‑containing protein 1 loss is associated with clinicopathological performance in glioma.
  9. Our data suggest a possible role of HMBOX1 in regulating radiosensitivity in cervical cancer cells.
    Title: Knockdown of homeobox containing 1 increases the radiosensitivity of cervical cancer cells through telomere shortening.
  10. HMBOX1 regulates intracellular free zinc level by interacting with MT2A to inhibit apoptosis and promote autophagy in vascular endothelial cells.
    Title: HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21616

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables double-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomeric DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of telomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
  
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in chromosome, telomeric region HDA PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
homeobox-containing protein 1
Names
homeobox telomere-binding protein 1
homeobox-containing protein PBHNF
telomere-associated homeobox-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135726.3 → NP_001129198.1  homeobox-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001129198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (1).
    Source sequence(s)
    AC108449, AK290683, BQ019252
    Consensus CDS
    CCDS6071.1
    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
    UniProtKB/TrEMBL
    E5RGZ2
    Related
    ENSP00000287701.10, ENST00000287701.15
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  2. NM_001324382.2 → NP_001311311.1  homeobox-containing protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (1).
    Source sequence(s)
    AC040975, AC108449, AK290683, BQ019252, DC358620, DC395744
    Consensus CDS
    CCDS6071.1
    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  3. NM_001324383.2 → NP_001311312.1  homeobox-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, AK295320, BC069242, BQ019252
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  4. NM_001324384.1 → NP_001311313.1  homeobox-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, AK295320, BC069242, BQ019252
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  5. NM_001324385.2 → NP_001311314.1  homeobox-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC040975, AC091558, AC108449, AK290683, BQ019252
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  6. NM_001324386.2 → NP_001311315.1  homeobox-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, BQ019252, DQ153248
    UniProtKB/TrEMBL
    E5RGZ2
    Related
    ENSP00000430059.1, ENST00000519047.5
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  7. NM_001324387.2 → NP_001311316.1  homeobox-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, BQ019252, DQ153248
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  8. NM_001324388.2 → NP_001311317.1  homeobox-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC040975, AC108449, AK290683, BQ019252, DC358620, DC395744, DQ153248
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  9. NM_001324389.2 → NP_001311318.1  homeobox-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC040975, AC091558, AC108449, AK290683, BQ019252
    UniProtKB/TrEMBL
    H0YLF2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  10. NM_001324390.1 → NP_001311319.1  homeobox-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC091558, AC108449, BC069242, BQ019252
    UniProtKB/TrEMBL
    H0YLF2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  11. NM_001324391.2 → NP_001311320.1  homeobox-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, BC009259, BQ019252
    Consensus CDS
    CCDS83274.1
    UniProtKB/TrEMBL
    E5RGZ2
    Related
    ENSP00000453211.1, ENST00000558662.5
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  12. NM_001324392.1 → NP_001311321.1  homeobox-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC040975, AC091558, AC108449, BC069242, BQ019252
    Consensus CDS
    CCDS83274.1
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  13. NM_001324393.2 → NP_001311322.1  homeobox-containing protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, BC009259, BQ019252, DC341559, DQ153248
    UniProtKB/TrEMBL
    H0YLF2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  14. NM_001324394.2 → NP_001311323.1  homeobox-containing protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, BC009259, BQ019252, DC341559, DQ153248
    UniProtKB/TrEMBL
    H0YLF2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  15. NM_001324395.2 → NP_001311324.1  homeobox-containing protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, BC009259, BQ019252
    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  16. NM_001330498.2 → NP_001317427.1  homeobox-containing protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC108449, BF369137, BQ019252, BX353564, HY077398
    Consensus CDS
    CCDS83273.1
    UniProtKB/TrEMBL
    E5RGZ2
    Related
    ENSP00000430110.1, ENST00000524238.3
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  17. NM_024567.4 → NP_078843.2  homeobox-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_078843.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, and 3 all encode the same isoform (1).
    Source sequence(s)
    AC108449, BC069242, BQ019252
    Consensus CDS
    CCDS6071.1
    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701
    UniProtKB/TrEMBL
    E5RGZ2
    Related
    ENSP00000380516.3, ENST00000397358.7
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RNA

  1. NR_136757.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108449, AK290683, BC009259, BQ019252

  2. NR_136758.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA400589, AC108449, AK290683, BQ019252, DQ153248

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    28890116..29053270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422223.1 → XP_047278179.1  homeobox-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701

  2. XM_017013823.3 → XP_016869312.1  homeobox-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    E5RGZ2
    Conserved Domains (2) summary
    cd00086
    Location:268 → 340
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 227
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

  3. XM_047422219.1 → XP_047278175.1  homeobox-containing protein 1 isoform X1

  4. XM_047422224.1 → XP_047278180.1  homeobox-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701

  5. XM_047422227.1 → XP_047278183.1  homeobox-containing protein 1 isoform X5

  6. XM_006716398.3 → XP_006716461.1  homeobox-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    H0YLF2
    Related
    ENSP00000453185.1, ENST00000560599.5
    Conserved Domains (2) summary
    cd00086
    Location:268 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04814
    Location:25 → 226
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  7. XM_047422229.1 → XP_047278185.1  homeobox-containing protein 1 isoform X7

  8. XM_017013825.2 → XP_016869314.1  homeobox-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    H0YLF2
    Related
    ENSP00000430238.1, ENST00000521516.5
    Conserved Domains (1) summary
    pfam04814
    Location:25 → 226
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  9. XM_011544642.3 → XP_011542944.1  homeobox-containing protein 1 isoform X8

    Conserved Domains (1) summary
    pfam04814
    Location:25 → 226
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  10. XM_047422220.1 → XP_047278176.1  homeobox-containing protein 1 isoform X2

  11. XM_047422222.1 → XP_047278178.1  homeobox-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701

  12. XM_047422228.1 → XP_047278184.1  homeobox-containing protein 1 isoform X5

  13. XM_047422221.1 → XP_047278177.1  homeobox-containing protein 1 isoform X3

  14. XM_047422218.1 → XP_047278174.1  homeobox-containing protein 1 isoform X1

  15. XM_047422226.1 → XP_047278182.1  homeobox-containing protein 1 isoform X5

    Related
    ENSP00000475196.1, ENST00000355231.9

RNA

  1. XR_001745595.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    29168300..29331436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361209.1 → XP_054217184.1  homeobox-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701

  2. XM_054361203.1 → XP_054217178.1  homeobox-containing protein 1 isoform X1

  3. XM_054361205.1 → XP_054217180.1  homeobox-containing protein 1 isoform X1

  4. XM_054361210.1 → XP_054217185.1  homeobox-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701

  5. XM_054361212.1 → XP_054217187.1  homeobox-containing protein 1 isoform X5

  6. XM_054361214.1 → XP_054217189.1  homeobox-containing protein 1 isoform X6

  7. XM_054361216.1 → XP_054217191.1  homeobox-containing protein 1 isoform X7

  8. XM_054361215.1 → XP_054217190.1  homeobox-containing protein 1 isoform X7

  9. XM_054361217.1 → XP_054217192.1  homeobox-containing protein 1 isoform X8

  10. XM_054361206.1 → XP_054217181.1  homeobox-containing protein 1 isoform X2

  11. XM_054361208.1 → XP_054217183.1  homeobox-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    A4K385, A8K3R8, B4DHY5, D3DSU0, Q3Y6P1, Q6NT76, Q96GS5, Q9H701

  12. XM_054361213.1 → XP_054217188.1  homeobox-containing protein 1 isoform X5

  13. XM_054361207.1 → XP_054217182.1  homeobox-containing protein 1 isoform X3

  14. XM_054361204.1 → XP_054217179.1  homeobox-containing protein 1 isoform X1

  15. XM_054361211.1 → XP_054217186.1  homeobox-containing protein 1 isoform X5

RNA

  1. XR_008487881.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NT76.1 GenPept UniProtKB/Swiss-Prot:Q6NT76

Gene LinkOut

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