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ST7 suppression of tumorigenicity 7 [ Homo sapiens (human) ]

Gene ID: 7982, updated on 5-Mar-2024

Summary

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Official Symbol
ST7provided by HGNC
Official Full Name
suppression of tumorigenicity 7provided by HGNC
Primary source
HGNC:HGNC:11351
See related
Ensembl:ENSG00000004866 MIM:600833; AllianceGenome:HGNC:11351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A; FAM4A1
Summary
The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 11.1), lung (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7q31.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116953501..117230176)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (118268670..118545512)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116593555..116870230)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene uncharacterized LOC124901857 Neighboring gene greater CFTR locus negative regulatory element CR9 Neighboring gene Sharpr-MPRA regulatory region 2110 Neighboring gene uncharacterized LOC105375465 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18564 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116593626-116594549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18567 Neighboring gene RNA, 5S ribosomal pseudogene 239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18568 Neighboring gene NANOG hESC enhancer GRCh37_chr7:116609424-116609981 Neighboring gene ST7 antisense RNA 1 Neighboring gene ST7 overlapping transcript 4 Neighboring gene tropomyosin 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18569 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:116659304-116660503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26542 Neighboring gene microRNA 6132 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116716803-116717302 Neighboring gene greater CFTR locus negative regulatory element NR4 Neighboring gene uncharacterized LOC124901732 Neighboring gene ST7 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26543 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:116794856-116795649 Neighboring gene greater CFTR locus negative regulatory element CR10 Neighboring gene greater CFTR locus negative regulatory element CR11 Neighboring gene ST7 overlapping transcript 3 Neighboring gene uncharacterized LOC105375466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26545 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2 pseudogene Neighboring gene MT-ND2 pseudogene 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Localization and characterization of ST7 in cancer. Charong N, et al. J Cancer Res Clin Oncol, 2011 Jan. PMID 20238225
  2. Distinguishing protein-coding from non-coding RNAs through support vector machines. Liu J, et al. PLoS Genet, 2006 Apr. PMID 16683024, Free PMC Article
  3. Mutational analysis of the ST7 gene in human myeloid tumor cell lines. Sivasundaram K, et al. Oncol Rep, 2003 Nov-Dec. PMID 14534688
  4. An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. Wang S, et al. Oncogene, 2003 Jan 23. PMID 12545169
  5. Absence of ST7 gene alterations in human cancer. Dong SM, et al. Clin Cancer Res, 2002 Sep. PMID 12231539

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
    Title: Inflammation-dependent overexpression of c-Myc enhances CRL4(DCAF4) E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.
  2. The tumor suppressor ST7 is a key gene silenced by PRMT5.
    Title: Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.
  3. ST7 mediates tumor suppression through the regulation of the genes involved in maintaining the cellular structure of the cell and involved in oncogenic pathways
    Title: Localization and characterization of ST7 in cancer.
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  7. The ST7 gene is not a primary target of inactivation in most human cancers with loss of heterozygosity at 7q31.1-q31.2.
    Title: Absence of ST7 gene alterations in human cancer.
  8. Mutational analysis of ST7 in a wide range of cell lines and primary epithelial cancer failed to detect mutations at this locus, with the exception of 1 missense change in a breast cancer cell line.
    Title: Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours.
  9. somatic mutations of ST7 do not commonly contribute to the molecular pathogenesis of human malignant myeloid tumors
    Title: Mutational analysis of the ST7 gene in human myeloid tumor cell lines.
  10. ST7 gene may not be the target gene of inactivation at 7q31 site in gastric carcinoma.
    Title: Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp762O2113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suppressor of tumorigenicity 7 protein
Names
family with sequence similarity 4, subfamily A, member 1
suppression of tumorigenicity 7 (breast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047088.1 RefSeqGene

    Range
    5175..281850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001369598.1 → NP_001356527.1  suppressor of tumorigenicity 7 protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS94182.1
    UniProtKB/TrEMBL
    A8K8K7, H7BXS2
    Related
    ENSP00000325673.3, ENST00000323984.8
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 576
    ST7; ST7 protein

  2. NM_001369599.1 → NP_001356528.1  suppressor of tumorigenicity 7 protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS94185.1
    UniProtKB/TrEMBL
    A8K8K7, B7Z4L1
    Related
    ENSP00000377093.4, ENST00000393447.8
    Conserved Domains (1) summary
    cd11557
    Location:11 → 498
    ST7; Suppression of tumorigenicity 7

  3. NM_001369600.1 → NP_001356529.1  suppressor of tumorigenicity 7 protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS94186.1
    UniProtKB/TrEMBL
    A8K8K7, G3XAH9
    Related
    ENSP00000377090.3, ENST00000393444.7
    Conserved Domains (1) summary
    cd11557
    Location:11 → 475
    ST7; Suppression of tumorigenicity 7

  4. NM_001369601.1 → NP_001356530.1  suppressor of tumorigenicity 7 protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS94181.1
    UniProtKB/TrEMBL
    A8K8K7, E7EPD9
    Related
    ENSP00000377095.1, ENST00000393449.5
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 571
    ST7; ST7 protein

  5. NM_001369602.1 → NP_001356531.1  suppressor of tumorigenicity 7 protein isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS94183.1
    UniProtKB/TrEMBL
    A8K8K7, B7Z4U3
    Related
    ENSP00000411118.1, ENST00000432298.5
    Conserved Domains (1) summary
    cd11557
    Location:8 → 495
    ST7; Suppression of tumorigenicity 7

  6. NM_001369603.1 → NP_001356532.1  suppressor of tumorigenicity 7 protein isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS94184.1
    UniProtKB/TrEMBL
    A8K8K7, E7EPW5
    Related
    ENSP00000414031.1, ENST00000422922.5
    Conserved Domains (1) summary
    cd11557
    Location:8 → 472
    ST7; Suppression of tumorigenicity 7

  7. NM_001369604.1 → NP_001356533.1  suppressor of tumorigenicity 7 protein isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC106873
    UniProtKB/TrEMBL
    B7Z573
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 525
    ST7; ST7 protein

  8. NM_001369606.1 → NP_001356535.1  suppressor of tumorigenicity 7 protein isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    UniProtKB/TrEMBL
    A8K8K7
    Related
    ENSP00000377089.1, ENST00000393443.5
    Conserved Domains (1) summary
    cd11557
    Location:4 → 491
    ST7; Suppression of tumorigenicity 7

  9. NM_001369607.1 → NP_001356536.1  suppressor of tumorigenicity 7 protein isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    UniProtKB/TrEMBL
    A8K8K7
    Conserved Domains (1) summary
    cd11557
    Location:4 → 468
    ST7; Suppression of tumorigenicity 7

  10. NM_018412.4 → NP_060882.2  suppressor of tumorigenicity 7 protein isoform 5

    See identical proteins and their annotated locations for NP_060882.2

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873
    Consensus CDS
    CCDS5769.1
    UniProtKB/TrEMBL
    A8K8K7
    Related
    ENSP00000377097.3, ENST00000393451.7
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 553
    ST7; ST7 protein

  11. NM_021908.3 → NP_068708.1  suppressor of tumorigenicity 7 protein isoform 8

    See identical proteins and their annotated locations for NP_068708.1

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC106873
    Consensus CDS
    CCDS5770.1
    UniProtKB/Swiss-Prot
    A4D0V2, Q5CZ72, Q7LE31, Q7LE32, Q8NA32, Q8NEJ8, Q8TDI9, Q9BWX3, Q9BWX4, Q9NRC1, Q9NRC2, Q9NXZ7
    UniProtKB/TrEMBL
    B7Z573, X5DRA0
    Related
    ENSP00000265437.5, ENST00000265437.9
    Conserved Domains (1) summary
    pfam04184
    Location:19 → 548
    ST7; ST7 protein

RNA

  1. NR_161418.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462

  2. NR_161419.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462

  3. NR_161420.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462

  4. NR_161421.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873, HY033462

  5. NR_161422.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873

  6. NR_161423.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002542, AC003987, AC106873

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    116953501..117230176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    118268670..118545512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRC1.1 GenPept UniProtKB/Swiss-Prot:Q9NRC1

Gene LinkOut

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