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QSER1 glutamine and serine rich 1 [ Homo sapiens (human) ]

Gene ID: 79832, updated on 3-Apr-2024

Summary

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Official Symbol
QSER1provided by HGNC
Official Full Name
glutamine and serine rich 1provided by HGNC
Primary source
HGNC:HGNC:26154
See related
Ensembl:ENSG00000060749 MIM:619440; AllianceGenome:HGNC:26154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 5.9), testis (RPKM 5.5) and 25 other tissues See more
Orthologs
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Genomic context

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See QSER1 in Genome Data Viewer
Location:
11p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32892811..32980270)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33028395..33115866)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32914357..33001816)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4567 Neighboring gene proline rich and Gla domain 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:32912708-32913282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4568 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32968504-32968654 Neighboring gene uncharacterized LOC105376615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33022947-33023448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33060521-33061068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4572 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:33071407-33071907 Neighboring gene DEP domain containing 7 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33082368-33083567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:33089797-33090298 Neighboring gene t-complex 11 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. QSER1 protects DNA methylation valleys from de novo methylation. Dixon G, et al. Science, 2021 Apr 9. PMID 33833093, Free PMC Article
  2. Genomewide association study for onset age in Parkinson disease. Latourelle JC, et al. BMC Med Genet, 2009 Sep 22. PMID 19772629, Free PMC Article
  3. Identification of the BRD1 interaction network and its impact on mental disorder risk. Fryland T, et al. Genome Med, 2016 May 3. PMID 27142060, Free PMC Article
  4. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Béguelin W, et al. Cancer Cell, 2016 Aug 8. PMID 27505670, Free PMC Article
  5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. QSER1 protects DNA methylation valleys from de novo methylation.
    Title: QSER1 protects DNA methylation valleys from de novo methylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomewide association study for onset age in Parkinson disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21924

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamine and serine-rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076786.3 → NP_001070254.2  glutamine and serine-rich protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC107939, AK025577, AK126023, AL035400, AL834141, BC112935
    Consensus CDS
    CCDS41631.2
    UniProtKB/Swiss-Prot
    Q2KHR3, Q6ZU30, Q6ZUR5
    UniProtKB/TrEMBL
    A0A3B3IRW6
    Related
    ENSP00000496900.1, ENST00000650167.2

  2. NM_001416036.1 → NP_001402965.1  glutamine and serine-rich protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107939, AL035400

  3. NM_001416037.1 → NP_001402966.1  glutamine and serine-rich protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107939, AL035400

  4. NM_001416038.1 → NP_001402967.1  glutamine and serine-rich protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC107939, AL035400

  5. NM_001416039.1 → NP_001402968.1  glutamine and serine-rich protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC107939, AL035400

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    32892811..32980270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427611.1 → XP_047283567.1  glutamine and serine-rich protein 1 isoform X1

  2. XM_017018330.2 → XP_016873819.2  glutamine and serine-rich protein 1 isoform X2

  3. XM_047427613.1 → XP_047283569.1  glutamine and serine-rich protein 1 isoform X3

  4. XM_047427614.1 → XP_047283570.1  glutamine and serine-rich protein 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    33028395..33115866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369989.1 → XP_054225964.1  glutamine and serine-rich protein 1 isoform X1

  2. XM_054369990.1 → XP_054225965.1  glutamine and serine-rich protein 1 isoform X2

  3. XM_054369991.1 → XP_054225966.1  glutamine and serine-rich protein 1 isoform X3

  4. XM_054369992.1 → XP_054225967.1  glutamine and serine-rich protein 1 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024774.2: Suppressed sequence

    Description
    NM_024774.2: This RefSeq was temporarily suppressed because there was a mismatch compared to available sequence data that resulted in premature translation termination. The C-terminus of the corrected protein is not supported by
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KHR3.3 GenPept UniProtKB/Swiss-Prot:Q2KHR3

Gene LinkOut

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