U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF671 zinc finger protein 671 [ Homo sapiens (human) ]

Gene ID: 79891, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF671provided by HGNC
Official Full Name
zinc finger protein 671provided by HGNC
Primary source
HGNC:HGNC:26279
See related
Ensembl:ENSG00000083814 AllianceGenome:HGNC:26279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 4.7), lymph node (RPKM 4.6) and 25 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF671 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57719751..57727624, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60816684..60824556, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58231119..58238992, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 154 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58220160-58220799 Neighboring gene uncharacterized LOC124904783 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58238691-58239191 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58239145-58239370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15157 Neighboring gene zinc finger protein 776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58280768-58281307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15159 Neighboring gene zinc finger protein 586

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zinc finger protein 671 has a cancer-inhibiting function in colorectal carcinoma via the deactivation of Notch signaling. Wang Y, et al. Toxicol Appl Pharmacol, 2023 Jan 1. PMID 36436566
  2. ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer. Mase S, et al. Cancer Sci, 2019 Mar. PMID 30633424, Free PMC Article
  3. Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest. Zhang J, et al. J Exp Clin Cancer Res, 2017 Oct 19. PMID 29052525, Free PMC Article
  4. Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma. Yeh CM, et al. Oncotarget, 2015 Oct 6. PMID 26320192, Free PMC Article
  5. Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma. Zhang W, et al. Int J Biol Sci, 2023. PMID 37215982, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma.
    Title: Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma.
  2. Zinc finger protein 671 has a cancer-inhibiting function in colorectal carcinoma via the deactivation of Notch signaling.
    Title: Zinc finger protein 671 has a cancer-inhibiting function in colorectal carcinoma via the deactivation of Notch signaling.
  3. ZNF671 functions as a tumor suppressor in ovarian cancer.
    Title: ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer.
  4. Data show that mRNA and protein expression of ZNF671 are down-regulated in nasopharyngeal cancer (NPC) tissues and cell lines. Its downregulation promotes NPC cell proliferation and tumorigenicity by facilitating cell cycle progression. These results suggest that ZNF671 is a potential tumor suppressor which epigenetically silenced by promoter methylation in NPC.
    Title: Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest.
  5. In particular, methylation levels of ITGA4, RERG, and ZNF671 could distinguish Nasopharyngeal carcinoma (NPC) patients from non-cancer nasopharyngeal epithelium (NNE) subjects. We identified the DNA methylation rates of previously unidentified NPC candidate genes.
    Title: Quantitation of DNA methylation in Epstein-Barr virus-associated nasopharyngeal carcinoma by bisulfite amplicon sequencing.
  6. Data show that ZNF671, an epigenetically silenced tumor suppressor, represents a potential predictor for urothelial carcinoma (UC) relapse and non-invasive biomarker that could assist in UC clinical decision-making.
    Title: Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ23506

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 671

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321375.2 → NP_001308304.1  zinc finger protein 671 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC003006, AK293680, DB132318
    UniProtKB/TrEMBL
    B7Z1N1
    Conserved Domains (4) summary
    COG5048
    Location:187 → 345
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:273 → 293
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:271 → 293
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:202 → 226
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001321376.2 → NP_001308305.1  zinc finger protein 671 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC003006, AK091421, DB132318
    Conserved Domains (5) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:208 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294 → 314
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:292 → 314
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:223 → 247
    zf-H2C2_2; Zinc-finger double domain

  3. NM_024833.3 → NP_079109.2  zinc finger protein 671 isoform 1

    See identical proteins and their annotated locations for NP_079109.2

    Status: VALIDATED

    Source sequence(s)
    AK027159, BC025728, DB104548
    Consensus CDS
    CCDS12961.1
    UniProtKB/Swiss-Prot
    A6NF07, Q8TAW3, Q9H5E9
    Related
    ENSP00000321848.5, ENST00000317398.10
    Conserved Domains (6) summary
    smart00349
    Location:49 → 109
    KRAB; krueppel associated box
    COG5048
    Location:285 → 443
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:371 → 391
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:369 → 391
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:49 → 88
    KRAB; KRAB box
    pfam13465
    Location:300 → 324
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57719751..57727624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027314.2 → XP_016882803.1  zinc finger protein 671 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:1 → 32
    KRAB; krueppel associated box
    COG5048
    Location:208 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294 → 314
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:292 → 314
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:223 → 247
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60816684..60824556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322203.1 → XP_054178178.1  zinc finger protein 671 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TAW3.2 GenPept UniProtKB/Swiss-Prot:Q8TAW3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous