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RPP21 ribonuclease P/MRP subunit p21 [ Homo sapiens (human) ]

Gene ID: 79897, updated on 7-Apr-2024

Summary

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Official Symbol
RPP21provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p21provided by HGNC
Primary source
HGNC:HGNC:21300
See related
Ensembl:ENSG00000241370 MIM:612524; AllianceGenome:HGNC:21300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAT60; C6orf135
Summary
RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]
Expression
Ubiquitous expression in endometrium (RPKM 10.7), ovary (RPKM 10.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30345156..30346857)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30209367..30211068)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30312933..30314634)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HLA complex group 17 Neighboring gene MPRA-validated peak5750 silencer Neighboring gene major histocompatibility complex, class I, L (pseudogene) Neighboring gene HLA complex group 18 Neighboring gene MPRA-validated peak5752 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:30292740-30293383 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:30296621-30297820 Neighboring gene TRIM39-RPP21 readthrough Neighboring gene tripartite motif containing 39 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:30308084-30309283 Neighboring gene NANOG hESC enhancer GRCh37_chr6:30323175-30323676 Neighboring gene major histocompatibility complex, class I, N (pseudogene) Neighboring gene ubiquilin 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Function and subnuclear distribution of Rpp21, a protein subunit of the human ribonucleoprotein ribonuclease P. Jarrous N, et al. RNA, 2001 Aug. PMID 11497433, Free PMC Article
  2. A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks. Abu-Zhayia ER, et al. Sci Rep, 2017 Apr 21. PMID 28432356, Free PMC Article
  3. cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein. Roberts JD Jr, et al. Am J Physiol Lung Cell Mol Physiol, 2007 Oct. PMID 17601797
  4. Protein-RNA interactions in the subunits of human nuclear RNase P. Jiang T, et al. RNA, 2001 Jul. PMID 11455963, Free PMC Article
  5. Sulindac suppresses beta-catenin expression in human cancer cells. Han A, et al. Eur J Pharmacol, 2008 Mar 31. PMID 18291362, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough TRIM39-RPP21

Readthrough gene: TRIM39-RPP21, Included gene: TRIM39

Homology

Clone Names

  • FLJ22638

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p21
Names
RNaseP protein p21
ribonuclease P/MRP 21kDa subunit
ribonucleoprotein V
NP_001186049.1
NP_001186050.1
NP_079115.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199120.3 → NP_001186049.1  ribonuclease P protein subunit p21 isoform 1

    See identical proteins and their annotated locations for NP_001186049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ504713, BG708140, BI598757, DA270919
    Consensus CDS
    CCDS56409.1
    UniProtKB/TrEMBL
    A0A0G2JIT5, A0A140T9R9, A0A1U9X8H1, A0A1U9X8H3
    Related
    ENSP00000409799.2, ENST00000433076.6
    Conserved Domains (1) summary
    pfam04032
    Location:13 → 103
    Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

  2. NM_001199121.3 → NP_001186050.1  ribonuclease P protein subunit p21 isoform 3

    See identical proteins and their annotated locations for NP_001186050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AJ504716, BG708140, DA270919
    Consensus CDS
    CCDS56410.1
    UniProtKB/TrEMBL
    A0A0G2JJY3
    Related
    ENSP00000397778.2, ENST00000436442.2
    Conserved Domains (1) summary
    pfam04032
    Location:13 → 96
    Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

  3. NM_024839.4 → NP_079115.1  ribonuclease P protein subunit p21 isoform 2

    See identical proteins and their annotated locations for NP_079115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AJ504713, BG708140, DA270919
    Consensus CDS
    CCDS4679.1
    UniProtKB/Swiss-Prot
    A2AAZ8, B0S834, B0S835, Q5JPL9, Q5JPM1, Q5STF8, Q5STF9, Q5STG2, Q5SU41, Q5SU42, Q86Y49, Q86Y50, Q86Y51, Q96F16, Q9H633
    UniProtKB/TrEMBL
    A0A0G2JJ26
    Related
    ENSP00000403833.2, ENST00000442966.7
    Conserved Domains (1) summary
    pfam04032
    Location:13 → 96
    Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30345156..30346857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1674652..1676353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    1824837..1826538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1601002..1602703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    1655390..1657091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1600238..1601939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    1643613..1645314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30209367..30211068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H633.1 GenPept UniProtKB/Swiss-Prot:Q9H633

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