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myhz1.2 myosin, heavy polypeptide 1.2, skeletal muscle [ Danio rerio (zebrafish) ]

Gene ID: 799300, updated on 11-Apr-2024

Summary

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Official Symbol
myhz1.2provided by ZNC
Official Full Name
myosin, heavy polypeptide 1.2, skeletal muscleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-73
See related
Ensembl:ENSDARG00000067995 AllianceGenome:ZFIN:ZDB-GENE-070705-73
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
myhc3; fmyhc1.2; ns:zf-e523; si:ch211-158m24.8
Summary
Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Predicted to be part of myosin complex. Is expressed in cephalic musculature and trunk. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; disease of cellular proliferation; and distal arthrogryposis (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1) and MYH8 (myosin heavy chain 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
41
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (32281815..32293000, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (31681662..31692825, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene myosin, heavy chain a Neighboring gene myosin, heavy polypeptide 1.3, skeletal muscle Neighboring gene myosin, heavy polypeptide 1.1, skeletal muscle Neighboring gene heat shock protein, alpha-crystallin-related, b15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Misty somites, a maternal effect gene identified by transposon-mediated insertional mutagenesis in zebrafish that is essential for the somite boundary maintenance. Kotani T, et al. Dev Biol, 2008 Apr 15. PMID 18342848, Free PMC Article
  2. 5'-flanking sequences of zebrafish fast myosin heavy chain genes regulate unique expression in the anterior, medial subsection and posterior tail somites of the skeletal muscle. Asaduzzaman M, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Jan. PMID 26335505
  3. Differential regulation of myosin heavy chains defines new muscle domains in zebrafish. Nord H, et al. Mol Biol Cell, 2014 Apr. PMID 24523292, Free PMC Article
  4. Ferulic Acid Promotes Hypertrophic Growth of Fast Skeletal Muscle in Zebrafish Model. Wen Y, et al. Nutrients, 2017 Sep 26. PMID 28954428, Free PMC Article
  5. MicroRNA-203a regulates fast muscle differentiation by targeting dmrt2a in zebrafish embryos. Lu C, et al. Gene, 2017 Aug 20. PMID 28483596

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin, heavy polypeptide 1.2, skeletal muscle
Names
fast skeletal myosin heavy chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161446.1 → NP_001154918.1  myosin, heavy polypeptide 1.2, skeletal muscle

    Status: PROVISIONAL

    Source sequence(s)
    BX510649
    UniProtKB/TrEMBL
    A0A2R8Q2N5, A0A8M1NUN9
    Related
    ENSDARP00000146874.1, ENSDART00000183522.1
    Conserved Domains (7) summary
    cd01377
    Location:101 → 768
    MYSc_class_II; class II myosins, motor domain
    pfam00063
    Location:89 → 768
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:848 → 1923
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:36 → 74
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam07851
    Location:1471 → 1581
    TMPIT; TMPIT-like protein
    cl00459
    Location:1297 → 1407
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl02488
    Location:881 → 1043
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    32281815..32293000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171924.4 → XP_005171981.1  myosin, heavy polypeptide 1.2, skeletal muscle isoform X1

    See identical proteins and their annotated locations for XP_005171981.1

    UniProtKB/TrEMBL
    A0A8M9QEC8, B8A561
    Related
    ENSDARP00000115054.1, ENSDART00000131983.2
    Conserved Domains (3) summary
    cd01377
    Location:101 → 768
    MYSc_class_II; class II myosins, motor domain
    pfam02736
    Location:35 → 74
    Myosin_N; Myosin N-terminal SH3-like domain
    cl25732
    Location:848 → 1925
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_021476335.1 → XP_021332010.1  myosin, heavy polypeptide 1.2, skeletal muscle isoform X1

    UniProtKB/TrEMBL
    A0A8M9QEC8, B8A561
    Conserved Domains (3) summary
    cd01377
    Location:101 → 768
    MYSc_class_II; class II myosins, motor domain
    pfam02736
    Location:35 → 74
    Myosin_N; Myosin N-terminal SH3-like domain
    cl25732
    Location:848 → 1925
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_009301554.3 → XP_009299829.1  myosin, heavy polypeptide 1.2, skeletal muscle isoform X1

    See identical proteins and their annotated locations for XP_009299829.1

    UniProtKB/TrEMBL
    A0A8M9QEC8, B8A561
    Conserved Domains (3) summary
    cd01377
    Location:101 → 768
    MYSc_class_II; class II myosins, motor domain
    pfam02736
    Location:35 → 74
    Myosin_N; Myosin N-terminal SH3-like domain
    cl25732
    Location:848 → 1925
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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