U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CEP63 centrosomal protein 63 [ Homo sapiens (human) ]

Gene ID: 80254, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
CEP63provided by HGNC
Official Full Name
centrosomal protein 63provided by HGNC
Primary source
HGNC:HGNC:25815
See related
Ensembl:ENSG00000182923 MIM:614724; AllianceGenome:HGNC:25815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCKL6
Summary
This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 6.9), fat (RPKM 3.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q22.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (134485724..134782559)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (137230895..137527929)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134204566..134293855)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:134124670-134125376 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134126084-134126789 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:134145749-134146948 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:134181408-134182134 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134183586-134184310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20562 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:134205013-134205831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20563 Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene microRNA 4788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134245816-134246316 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene DPPA4 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 9743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134338253-134338753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134361872-134362713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134362971-134363635 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134412480-134413158 Neighboring gene kyphoscoliosis peptidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20569 Neighboring gene Sharpr-MPRA regulatory region 6102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20571 Neighboring gene RNA, U6 small nuclear 1174, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:134565355-134565854 Neighboring gene uncharacterized LOC105374121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20574 Neighboring gene EPH receptor B1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1. Liu C, et al. Oncol Rep, 2021 Sep. PMID 34296302, Free PMC Article
  2. [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1]. Liu CG, et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2021 Jan 7. PMID 33472304
  3. Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family. Einarsdottir E, et al. Hum Genet, 2015 Nov. PMID 26400686, Free PMC Article
  4. Computational investigation of pathogenic nsSNPs in CEP63 protein. Kumar A, et al. Gene, 2012 Jul 15. PMID 22555018
  5. Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma. Mahjabeen I, et al. Future Oncol, 2021 Sep. PMID 34156311

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1.
    Title: CEP63 upregulates YAP1 to promote colorectal cancer progression through stabilizing RNA binding protein FXR1.
  2. Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma.
    Title: Polymorphism in miRNA target sites of CEP-63 and CEP-152 ring complex influences expression of CEP genes and favors tumorigenesis in glioma.
  3. Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC1.
    Title: Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1.
  4. CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression.
    Title: CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression.
  5. [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1].
    Title: [Study on Cep63 expression and apoptosis of thyroid papillary carcinoma cell lines TPC-1].
  6. Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.
    Title: Requirement of the Cep57-Cep63 Interaction for Proper Cep152 Recruitment and Centriole Duplication.
  7. Study shows that Cep63 and Cep152 cooperatively generate a heterotetrameric alpha-helical bundle that functions in conjunction with its neighboring hydrophobic motifs to self-assemble into a higher-order cylindrical architecture capable of recruiting downstream components, including Plk4, a key regulator for centriole duplication. Mutations disrupting the self-assembly abrogate Plk4-mediated centriole duplication.
    Title: Molecular architecture of a cylindrical self-assembly at human centrosomes.
  8. CEP63 is particularly important for brain development and might control the proliferation and migration of cells when those two events need to be highly coordinated.
    Title: Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.
  9. centrosomal Cdk1 signals were strongly diminished in cells treated with Cep63 siRNA when sc-54 was used for Cdk1 labeling
    Title: Cep63 recruits cdk1 to the centrosome-letter.
  10. both mouse and human Cep63 and Cep152 cooperate to ensure efficient centriole duplication by promoting the accumulation of essential centriole duplication factors upstream of SAS-6 recruitment and procentriole formation.
    Title: Cep63 and cep152 cooperate to ensure centriole duplication.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Seckel syndrome 6
MedGen: C3553582 OMIM: 614728 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association analysis identifies 20 loci that influence adult height.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ13386, MGC78416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
centrosomal protein of 63 kDa
Names
centrosomal protein 63kDa
centrosome protein CEP63

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032870.2 RefSeqGene

    Range
    5335..84309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042383.2 → NP_001035842.1  centrosomal protein of 63 kDa isoform c

    See identical proteins and their annotated locations for NP_001035842.1

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC109912, BC014050, BX499930, CX751767, N36992
    Consensus CDS
    CCDS43154.1
    UniProtKB/TrEMBL
    A0A804HKQ7
    Related
    ENSP00000328382.5, ENST00000332047.10
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247 → 495
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_001042384.2 → NP_001035843.1  centrosomal protein of 63 kDa isoform d

    See identical proteins and their annotated locations for NP_001035843.1

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC139764, AK023738, BG182631, BX499930, CX751767
    Consensus CDS
    CCDS43152.1
    UniProtKB/TrEMBL
    H0Y900
    Related
    ENSP00000346432.3, ENST00000354446.7
    Conserved Domains (2) summary
    COG1196
    Location:163 → 453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa

  3. NM_001042400.3 → NP_001035859.1  centrosomal protein of 63 kDa isoform b

    See identical proteins and their annotated locations for NP_001035859.1

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43153.1
    UniProtKB/TrEMBL
    A0A804HKH7
    Related
    ENSP00000372716.3, ENST00000383229.8
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 479
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001353108.3 → NP_001340037.1  centrosomal protein of 63 kDa isoform a

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS3086.1
    UniProtKB/Swiss-Prot
    D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
    Related
    ENSP00000502085.1, ENST00000675561.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001353109.1 → NP_001340038.1  centrosomal protein of 63 kDa isoform e

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Consensus CDS
    CCDS93389.1
    UniProtKB/TrEMBL
    A0A804HIX3
    Related
    ENSP00000507263.1, ENST00000682458.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136 → 463
    SMC_N; RecF/RecN/SMC N terminal domain

  6. NM_001353110.1 → NP_001340039.1  centrosomal protein of 63 kDa isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Consensus CDS
    CCDS43153.1
    UniProtKB/TrEMBL
    A0A804HKH7
    Related
    ENSP00000508291.1, ENST00000684217.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 479
    SMC_N; RecF/RecN/SMC N terminal domain

  7. NM_001353111.2 → NP_001340040.1  centrosomal protein of 63 kDa isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43153.1
    UniProtKB/TrEMBL
    A0A804HKH7
    Related
    ENSP00000507217.1, ENST00000684677.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 479
    SMC_N; RecF/RecN/SMC N terminal domain

  8. NM_001353112.2 → NP_001340041.1  centrosomal protein of 63 kDa isoform b

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43153.1
    UniProtKB/TrEMBL
    A0A804HKH7
    Related
    ENSP00000507704.1, ENST00000683608.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 479
    SMC_N; RecF/RecN/SMC N terminal domain

  9. NM_001353113.1 → NP_001340042.1  centrosomal protein of 63 kDa isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Consensus CDS
    CCDS93388.1
    UniProtKB/TrEMBL
    A0A804HKF0, H0YAL1
    Related
    ENSP00000507552.1, ENST00000683997.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136 → 464
    SMC_N; RecF/RecN/SMC N terminal domain

  10. NM_001353117.2 → NP_001340046.1  centrosomal protein of 63 kDa isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Consensus CDS
    CCDS93388.1
    UniProtKB/TrEMBL
    A0A804HKF0, H0YAL1
    Related
    ENSP00000427526.2, ENST00000514678.2
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136 → 464
    SMC_N; RecF/RecN/SMC N terminal domain

  11. NM_001353118.1 → NP_001340047.1  centrosomal protein of 63 kDa isoform g

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    UniProtKB/TrEMBL
    A0A804HKQ7
    Conserved Domains (2) summary
    pfam17045
    Location:27 → 289
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:256 → 504
    SMC_N; RecF/RecN/SMC N terminal domain

  12. NM_001353119.2 → NP_001340048.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43154.1
    UniProtKB/TrEMBL
    A0A804HKQ7
    Related
    ENSP00000506728.1, ENST00000683861.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247 → 495
    SMC_N; RecF/RecN/SMC N terminal domain

  13. NM_001353120.2 → NP_001340049.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43154.1
    UniProtKB/TrEMBL
    A0A804HKQ7
    Related
    ENSP00000507228.1, ENST00000682042.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247 → 495
    SMC_N; RecF/RecN/SMC N terminal domain

  14. NM_001353121.2 → NP_001340050.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS43154.1
    UniProtKB/TrEMBL
    A0A804HKQ7
    Related
    ENSP00000506828.1, ENST00000683177.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247 → 495
    SMC_N; RecF/RecN/SMC N terminal domain

  15. NM_001353122.1 → NP_001340051.1  centrosomal protein of 63 kDa isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Consensus CDS
    CCDS43154.1
    UniProtKB/TrEMBL
    A0A804HKQ7
    Related
    ENSP00000507703.1, ENST00000682858.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:247 → 495
    SMC_N; RecF/RecN/SMC N terminal domain

  16. NM_001353123.2 → NP_001340052.1  centrosomal protein of 63 kDa isoform d

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Consensus CDS
    CCDS43152.1
    UniProtKB/TrEMBL
    H0Y900
    Related
    ENSP00000482219.1, ENST00000620544.5
    Conserved Domains (2) summary
    COG1196
    Location:163 → 453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa

  17. NM_001353124.2 → NP_001340053.1  centrosomal protein of 63 kDa isoform d

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BG182631
    Consensus CDS
    CCDS43152.1
    UniProtKB/TrEMBL
    H0Y900
    Related
    ENSP00000423225.2, ENST00000512894.6
    Conserved Domains (2) summary
    COG1196
    Location:163 → 453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa

  18. NM_001353125.2 → NP_001340054.1  centrosomal protein of 63 kDa isoform h

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS93392.1
    UniProtKB/TrEMBL
    A0A804HJ73, A0A804HKK0
    Related
    ENSP00000507256.1, ENST00000684492.1
    Conserved Domains (2) summary
    pfam17045
    Location:1 → 252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:219 → 467
    SMC_N; RecF/RecN/SMC N terminal domain

  19. NM_001353126.2 → NP_001340055.1  centrosomal protein of 63 kDa isoform i

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    UniProtKB/TrEMBL
    A0A804HJP1
    Conserved Domains (2) summary
    pfam17045
    Location:6 → 159
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:42 → 320
    SMC_N; RecF/RecN/SMC N terminal domain

  20. NM_025180.5 → NP_079456.2  centrosomal protein of 63 kDa isoform a

    See identical proteins and their annotated locations for NP_079456.2

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Consensus CDS
    CCDS3086.1
    UniProtKB/Swiss-Prot
    D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
    Related
    ENSP00000426129.1, ENST00000513612.7
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_148352.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764

  2. NR_148353.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764

  3. NR_148354.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764
    Related
    ENST00000682013.1

  4. NR_148355.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010207, AC026117, AC109912, AC139764, BC014050
    Related
    ENST00000650279.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    134485724..134782559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453777.2 → XP_024309545.2  centrosomal protein of 63 kDa isoform X15

  2. XM_006713760.5 → XP_006713823.1  centrosomal protein of 63 kDa isoform X3

    See identical proteins and their annotated locations for XP_006713823.1

    UniProtKB/Swiss-Prot
    D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
    Related
    ENSP00000506896.1, ENST00000683596.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_047449002.1 → XP_047304958.1  centrosomal protein of 63 kDa isoform X10

  4. XM_047449007.1 → XP_047304963.1  centrosomal protein of 63 kDa isoform X12

  5. XM_005247795.6 → XP_005247852.1  centrosomal protein of 63 kDa isoform X2

    Conserved Domains (2) summary
    pfam13094
    Location:253 → 376
    CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
    pfam17045
    Location:27 → 289
    CEP63; Centrosomal protein of 63 kDa

  6. XM_047449010.1 → XP_047304966.1  centrosomal protein of 63 kDa isoform X13

  7. XM_047448999.1 → XP_047304955.1  centrosomal protein of 63 kDa isoform X6

  8. XM_047449015.1 → XP_047304971.1  centrosomal protein of 63 kDa isoform X18

    Related
    ENSP00000507472.1, ENST00000683940.1

  9. XM_047449005.1 → XP_047304961.1  centrosomal protein of 63 kDa isoform X10

  10. XM_017007249.2 → XP_016862738.1  centrosomal protein of 63 kDa isoform X7

    UniProtKB/TrEMBL
    A0A804HIX3
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136 → 463
    SMC_N; RecF/RecN/SMC N terminal domain

  11. XM_005247797.4 → XP_005247854.1  centrosomal protein of 63 kDa isoform X3

    See identical proteins and their annotated locations for XP_005247854.1

    UniProtKB/Swiss-Prot
    D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0
    Related
    ENSP00000475903.1, ENST00000606977.5
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:163 → 528
    SMC_N; RecF/RecN/SMC N terminal domain

  12. XM_017007248.3 → XP_016862737.1  centrosomal protein of 63 kDa isoform X7

    UniProtKB/TrEMBL
    A0A804HIX3
    Related
    ENSP00000507548.1, ENST00000682402.1
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136 → 463
    SMC_N; RecF/RecN/SMC N terminal domain

  13. XM_047449008.1 → XP_047304964.1  centrosomal protein of 63 kDa isoform X12

  14. XM_047449000.1 → XP_047304956.1  centrosomal protein of 63 kDa isoform X9

  15. XM_047449003.1 → XP_047304959.1  centrosomal protein of 63 kDa isoform X10

  16. XM_017007247.3 → XP_016862736.1  centrosomal protein of 63 kDa isoform X7

    UniProtKB/TrEMBL
    A0A804HIX3
    Conserved Domains (2) summary
    pfam17045
    Location:18 → 280
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:136 → 463
    SMC_N; RecF/RecN/SMC N terminal domain

  17. XM_047449009.1 → XP_047304965.1  centrosomal protein of 63 kDa isoform X12

  18. XM_024453769.2 → XP_024309537.1  centrosomal protein of 63 kDa isoform X4

    UniProtKB/TrEMBL
    A0A804HKR1
    Related
    ENSP00000508034.1, ENST00000683190.1
    Conserved Domains (2) summary
    pfam17045
    Location:1 → 252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135 → 500
    SMC_N; RecF/RecN/SMC N terminal domain

  19. XM_047449013.1 → XP_047304969.1  centrosomal protein of 63 kDa isoform X16

    UniProtKB/TrEMBL
    A0A804HL17
    Related
    ENSP00000508161.1, ENST00000684170.1

  20. XM_047449001.1 → XP_047304957.1  centrosomal protein of 63 kDa isoform X9

  21. XM_047449011.1 → XP_047304967.1  centrosomal protein of 63 kDa isoform X14

  22. XM_024453778.2 → XP_024309546.1  centrosomal protein of 63 kDa isoform X19

    UniProtKB/TrEMBL
    A0A804HJ73, A0A804HKK0
    Related
    ENSP00000507596.1, ENST00000682822.1
    Conserved Domains (2) summary
    pfam17045
    Location:1 → 252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:219 → 467
    SMC_N; RecF/RecN/SMC N terminal domain

  23. XM_024453768.2 → XP_024309536.1  centrosomal protein of 63 kDa isoform X1

    Conserved Domains (2) summary
    pfam17045
    Location:29 → 291
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:174 → 539
    SMC_N; RecF/RecN/SMC N terminal domain

  24. XM_047448998.1 → XP_047304954.1  centrosomal protein of 63 kDa isoform X5

  25. XM_047449006.1 → XP_047304962.1  centrosomal protein of 63 kDa isoform X11

  26. XM_047448996.1 → XP_047304952.1  centrosomal protein of 63 kDa isoform X3

    UniProtKB/Swiss-Prot
    D3DND8, D3DND9, D3DNE0, Q96CR0, Q96MT8, Q9H8F5, Q9H8N0

  27. XM_024453771.2 → XP_024309539.1  centrosomal protein of 63 kDa isoform X4

    UniProtKB/TrEMBL
    A0A804HKR1
    Conserved Domains (2) summary
    pfam17045
    Location:1 → 252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135 → 500
    SMC_N; RecF/RecN/SMC N terminal domain

  28. XM_024453772.2 → XP_024309540.1  centrosomal protein of 63 kDa isoform X8

    Conserved Domains (2) summary
    pfam17045
    Location:1 → 252
    CEP63; Centrosomal protein of 63 kDa
    cl25732
    Location:135 → 500
    SMC_N; RecF/RecN/SMC N terminal domain

  29. XM_047449014.1 → XP_047304970.1  centrosomal protein of 63 kDa isoform X17

RNA

  1. XR_007095732.1 RNA Sequence

  2. XR_002959589.2 RNA Sequence

  3. XR_007095733.1 RNA Sequence

  4. XR_007095735.1 RNA Sequence

  5. XR_007095734.1 RNA Sequence

  6. XR_007095731.1 RNA Sequence

  7. XR_007095730.1 RNA Sequence

  8. XR_007095729.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    137230895..137527929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347996.1 → XP_054203971.1  centrosomal protein of 63 kDa isoform X15

  2. XM_054347974.1 → XP_054203949.1  centrosomal protein of 63 kDa isoform X3

  3. XM_054347987.1 → XP_054203962.1  centrosomal protein of 63 kDa isoform X10

  4. XM_054347991.1 → XP_054203966.1  centrosomal protein of 63 kDa isoform X12

  5. XM_054347973.1 → XP_054203948.1  centrosomal protein of 63 kDa isoform X2

  6. XM_054347994.1 → XP_054203969.1  centrosomal protein of 63 kDa isoform X13

  7. XM_054347980.1 → XP_054203955.1  centrosomal protein of 63 kDa isoform X6

  8. XM_054347999.1 → XP_054203974.1  centrosomal protein of 63 kDa isoform X18

  9. XM_054347989.1 → XP_054203964.1  centrosomal protein of 63 kDa isoform X10

  10. XM_054347983.1 → XP_054203958.1  centrosomal protein of 63 kDa isoform X7

  11. XM_054347975.1 → XP_054203950.1  centrosomal protein of 63 kDa isoform X3

  12. XM_054347982.1 → XP_054203957.1  centrosomal protein of 63 kDa isoform X7

  13. XM_054347992.1 → XP_054203967.1  centrosomal protein of 63 kDa isoform X12

  14. XM_054347985.1 → XP_054203960.1  centrosomal protein of 63 kDa isoform X9

  15. XM_054347988.1 → XP_054203963.1  centrosomal protein of 63 kDa isoform X10

  16. XM_054347981.1 → XP_054203956.1  centrosomal protein of 63 kDa isoform X7

  17. XM_054347993.1 → XP_054203968.1  centrosomal protein of 63 kDa isoform X12

  18. XM_054347977.1 → XP_054203952.1  centrosomal protein of 63 kDa isoform X4

  19. XM_054347997.1 → XP_054203972.1  centrosomal protein of 63 kDa isoform X16

    UniProtKB/TrEMBL
    A0A804HL17

  20. XM_054347986.1 → XP_054203961.1  centrosomal protein of 63 kDa isoform X9

  21. XM_054347995.1 → XP_054203970.1  centrosomal protein of 63 kDa isoform X14

  22. XM_054348000.1 → XP_054203975.1  centrosomal protein of 63 kDa isoform X19

    UniProtKB/TrEMBL
    A0A804HKK0

  23. XM_054347972.1 → XP_054203947.1  centrosomal protein of 63 kDa isoform X1

  24. XM_054347979.1 → XP_054203954.1  centrosomal protein of 63 kDa isoform X5

  25. XM_054347990.1 → XP_054203965.1  centrosomal protein of 63 kDa isoform X11

  26. XM_054347976.1 → XP_054203951.1  centrosomal protein of 63 kDa isoform X3

  27. XM_054347978.1 → XP_054203953.1  centrosomal protein of 63 kDa isoform X4

  28. XM_054347984.1 → XP_054203959.1  centrosomal protein of 63 kDa isoform X8

  29. XM_054347998.1 → XP_054203973.1  centrosomal protein of 63 kDa isoform X17

RNA

  1. XR_008486804.1 RNA Sequence

  2. XR_008486807.1 RNA Sequence

  3. XR_008486805.1 RNA Sequence

  4. XR_008486808.1 RNA Sequence

  5. XR_008486806.1 RNA Sequence

  6. XR_008486803.1 RNA Sequence

  7. XR_008486802.1 RNA Sequence

  8. XR_008486801.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96MT8.1 GenPept UniProtKB/Swiss-Prot:Q96MT8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous