Format

Send to:

Choose Destination

ZFP91 ZFP91 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 80829, updated on 11-Sep-2019

Summary

Official Symbol
ZFP91provided by HGNC
Official Full Name
ZFP91 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:14983
See related
Ensembl:ENSG00000186660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PZF; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757
Summary
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
Expression
Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues See more
Orthologs

Genomic context

See ZFP91 in Genome Data Viewer
Location:
11q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (58579063..58621550)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58346587..58389023)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369313 Neighboring gene olfactory receptor family 5 subfamily B member 21 Neighboring gene leupaxin Neighboring gene ZFP91-CNTF readthrough (NMD candidate) Neighboring gene ciliary neurotrophic factor Neighboring gene glycine-N-acyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with zinc finger protein 91 homolog (ZFP91) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ57065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of NF-kappaB-inducing kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase ZFP91
Names
RING-type E3 ubiquitin transferase ZFP91
drug resistance-associated sequence in melanoma 8
penta zinc finger protein
zinc finger protein 757
zinc finger protein 91 homolog
zinc finger protein homologous to Zfp91 in mouse
NP_001183980.1
NP_444251.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197051.2NP_001183980.1  E3 ubiquitin-protein ligase ZFP91 isoform 2

    See identical proteins and their annotated locations for NP_001183980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AB056107, AI687439, AP001350, BC051743, BP219969
    UniProtKB/Swiss-Prot
    Q96JP5
    UniProtKB/TrEMBL
    A0A024R4Z4
    Conserved Domains (3) summary
    sd00017
    Location:346365
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385410
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:312389
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_053023.5NP_444251.1  E3 ubiquitin-protein ligase ZFP91 isoform 1

    See identical proteins and their annotated locations for NP_444251.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB056107, AI687439, AP001350, BC051743, BP219969
    Consensus CDS
    CCDS31553.1
    UniProtKB/Swiss-Prot
    Q96JP5
    UniProtKB/TrEMBL
    A0A024R4Z1
    Related
    ENSP00000339030.5, ENST00000316059.7
    Conserved Domains (3) summary
    sd00017
    Location:347366
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:386411
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:313390
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    58579063..58621550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center