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Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta [ Mus musculus (house mouse) ]

Gene ID: 80859, updated on 2-Oct-2021

Summary

Official Symbol
Nfkbizprovided by MGI
Official Full Name
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zetaprovided by MGI
Primary source
MGI:MGI:1931595
See related
Ensembl:ENSMUSG00000035356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
INAP; Mail; AA408868
Expression
Broad expression in duodenum adult (RPKM 28.5), small intestine adult (RPKM 21.5) and 20 other tissues See more
Orthologs
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Genomic context

See Nfkbiz in Genome Data Viewer
Location:
16; 16 C1.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55631740..55659004, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (55811375..55838954, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (55811490..55838754, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53929 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene predicted gene, 26369 Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene conserved helix-loop-helix ubiquitous kinase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NF-kappa-B inhibitor zeta
Names
I-kappa-B-zeta
IL-1 inducible nuclear ankyrin-repeat protein
IkappaB-zeta
ikB-zeta
ikappaBzeta
molecule possessing ankyrin-repeats induced by lipopolysaccharide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159394.1NP_001152866.1  NF-kappa-B inhibitor zeta isoform a

    See identical proteins and their annotated locations for NP_001152866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AB026551, AK082908
    Consensus CDS
    CCDS28216.1
    UniProtKB/Swiss-Prot
    Q9EST8
    Related
    ENSMUSP00000110102.2, ENSMUST00000114458.8
    Conserved Domains (3) summary
    PHA03095
    Location:505701
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:561619
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:458546
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001159395.1NP_001152867.1  NF-kappa-B inhibitor zeta isoform b

    See identical proteins and their annotated locations for NP_001152867.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the alternate exon that in variant 1 contains the translation start site. This results in a downstream in-frame translation start site being used. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AB047549, AK159171
    Consensus CDS
    CCDS49869.1
    UniProtKB/Swiss-Prot
    Q9EST8
    Related
    ENSMUSP00000110101.2, ENSMUST00000114457.8
    Conserved Domains (4) summary
    cd00204
    Location:418584
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:359447
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:509567
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:462520
    ANK; ANK repeat [structural motif]
  3. NM_030612.3NP_085115.1  NF-kappa-B inhibitor zeta isoform a

    See identical proteins and their annotated locations for NP_085115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AB026551, AB047549, AK159171
    Consensus CDS
    CCDS28216.1
    UniProtKB/Swiss-Prot
    Q9EST8
    Related
    ENSMUSP00000041173.7, ENSMUST00000036273.13
    Conserved Domains (3) summary
    PHA03095
    Location:505701
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:561619
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:458546
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    55631740..55659004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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