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Kank3 KN motif and ankyrin repeat domains 3 [ Mus musculus (house mouse) ]

Gene ID: 80880, updated on 11-Apr-2024

Summary

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Official Symbol
Kank3provided by MGI
Official Full Name
KN motif and ankyrin repeat domains 3provided by MGI
Primary source
MGI:MGI:1098615
See related
Ensembl:ENSMUSG00000042099 AllianceGenome:MGI:1098615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NG28; Ankrd47; D17Ertd288e; 0610013D04Rik
Summary
Predicted to be involved in negative regulation of actin filament polymerization. Predicted to act upstream of or within negative regulation of stress fiber assembly. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; jaw bone; and liver. Orthologous to human KANK3 (KN motif and ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 77.6), adrenal adult (RPKM 51.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34029497..34041894)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33810523..33822920)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RAB11B, member RAS oncogene family Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1 Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene angiopoietin-like 4 Neighboring gene predicted gene, 53997 Neighboring gene STARR-seq mESC enhancer starr_42411 Neighboring gene STARR-positive B cell enhancer ABC_E956 Neighboring gene STARR-positive B cell enhancer ABC_E2482 Neighboring gene ribosomal protein S28 Neighboring gene NADH:ubiquinone oxidoreductase subunit A7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. Zhu Y, et al. Biochim Biophys Acta, 2008 Feb. PMID 17996375
  2. Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Quintens R, et al. Biol Open, 2015 Feb 13. PMID 25681390, Free PMC Article
  3. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins. Guo SS, et al. Exp Cell Res, 2021 Jan 1. PMID 33253712
  4. The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene. Logunova N, et al. PLoS Genet, 2015 Nov. PMID 26618355, Free PMC Article
  5. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
    Title: Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 3
Names
ankyrin repeat domain 47
ankyrin repeat domain-containing protein 47
putative KN motif and ankyrin repeat domains 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357162.1 → NP_001344091.1  KN motif and ankyrin repeat domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI847524, AK002623, BC037741
    Consensus CDS
    CCDS89070.1
    UniProtKB/TrEMBL
    Q6P8V1
    Related
    ENSMUSP00000133625.2, ENSMUST00000173789.2
    Conserved Domains (2) summary
    cd00204
    Location:17 → 148
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:23 → 58
    ANK; ANK repeat [structural motif]

  2. NM_030697.3 → NP_109622.1  KN motif and ankyrin repeat domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_109622.1

    Status: VALIDATED

    Source sequence(s)
    AI847524, AK002623
    Consensus CDS
    CCDS28630.1
    UniProtKB/Swiss-Prot
    Q9Z1P7
    UniProtKB/TrEMBL
    A0A068BIR7
    Related
    ENSMUSP00000040126.5, ENSMUST00000048560.11
    Conserved Domains (5) summary
    cd00204
    Location:601 → 733
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12075
    Location:32 → 73
    KN_motif; KN motif
    pfam12796
    Location:611 → 710
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:699 → 754
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:606 → 638
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34029497..34041894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525175.5 → XP_006525238.1  KN motif and ankyrin repeat domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006525238.1

    UniProtKB/TrEMBL
    A0A068BIR7
    Conserved Domains (5) summary
    COG0666
    Location:614 → 760
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    TIGR02231
    Location:139 → 260
    TIGR02231; conserved hypothetical protein
    sd00045
    Location:619 → 651
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:45 → 86
    KN_motif; KN motif
    pfam12796
    Location:730 → 793
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1P7.1 GenPept UniProtKB/Swiss-Prot:Q9Z1P7

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