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Rnf114 ring finger protein 114 [ Mus musculus (house mouse) ]

Gene ID: 81018, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf114provided by MGI
Official Full Name
ring finger protein 114provided by MGI
Primary source
MGI:MGI:1933159
See related
Ensembl:ENSMUSG00000006418 AllianceGenome:MGI:1933159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp228; Zfp313; Znf228; 1110008J21Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in cytosol and plasma membrane. Is expressed in early conceptus and genitourinary system. Orthologous to human RNF114 (ring finger protein 114). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 45.5), large intestine adult (RPKM 37.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf114 in Genome Data Viewer
Location:
2 H3; 2 87.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (167334565..167358093)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (167492645..167516173)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5 Neighboring gene STARR-positive B cell enhancer ABC_E2061 Neighboring gene STARR-positive B cell enhancer ABC_E7887 Neighboring gene STARR-positive B cell enhancer ABC_E419 Neighboring gene STARR-positive B cell enhancer mm9_chr2:167200540-167200841 Neighboring gene STARR-positive B cell enhancer ABC_E4522 Neighboring gene STARR-seq mESC enhancer starr_06429 Neighboring gene STARR-positive B cell enhancer ABC_E7888 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 8 Neighboring gene STARR-seq mESC enhancer starr_06433 Neighboring gene STARR-positive B cell enhancer ABC_E9075 Neighboring gene spermatogenesis associated 2 Neighboring gene STARR-seq mESC enhancer starr_06435 Neighboring gene STARR-positive B cell enhancer mm9_chr2:167363409-167363710 Neighboring gene predicted gene 11474 Neighboring gene snail family zinc finger 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos. Zhou S, et al. Development, 2021 Jul 1. PMID 34104941
  2. Cloning and expression analysis of a novel mouse zinc finger protein gene Znf313 abundantly expressed in testis. Li N, et al. J Biochem Mol Biol, 2007 Mar 31. PMID 17394778
  3. The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition. Yang Y, et al. EMBO Rep, 2017 Feb. PMID 28073917, Free PMC Article
  4. ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). Han J, et al. Cell Death Differ, 2013 Aug. PMID 23645206, Free PMC Article
  5. Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114. Lin B, et al. Cytokine, 2017 Nov. PMID 28625874

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos.
    Title: Maternal RNF114-mediated target substrate degradation regulates zygotic genome activation in mouse embryos.
  2. These data suggested the potential physiological function of RNF114 in inflammation and host antiviral responses, but demonstrate complexity in the regulation of innate immunity by ubiquitin ligases.
    Title: Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.
  3. our study uncovers that RNF114-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB pathway during MZT, and thus directly link maternal clearance to early embryo development.
    Title: The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition.
  4. ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
    Title: ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.).
  5. Present data suggests that Znf313 gene might play a fundamental role in gene transcription and regulation and relates to spermatogenesis.
    Title: Cloning and expression analysis of a novel mouse zinc finger protein gene Znf313 abundantly expressed in testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF114
Names
RING-type E3 ubiquitin transferase RNF114
zinc finger protein 313
NP_001347859.1
NP_109668.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360930.1 → NP_001347859.1  E3 ubiquitin-protein ligase RNF114 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AF502145, AK148290
    Consensus CDS
    CCDS17101.1
    UniProtKB/Swiss-Prot
    Q3UFU8, Q8K5A2, Q9ET26
    Related
    ENSMUSP00000077197.7, ENSMUST00000078050.7
    Conserved Domains (2) summary
    pfam05605
    Location:141 → 201
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cd16540
    Location:28 → 69
    RING-HC_RNF114; RING finger, HC subclass, found in RING finger protein 114 (RNF114) and similar proteins

  2. NM_030743.6 → NP_109668.2  E3 ubiquitin-protein ligase RNF114 isoform 1

    See identical proteins and their annotated locations for NP_109668.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AL589870
    Consensus CDS
    CCDS17101.1
    UniProtKB/Swiss-Prot
    Q3UFU8, Q8K5A2, Q9ET26
    Related
    ENSMUSP00000104837.2, ENSMUST00000109214.8
    Conserved Domains (2) summary
    pfam05605
    Location:141 → 201
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cd16540
    Location:28 → 69
    RING-HC_RNF114; RING finger, HC subclass, found in RING finger protein 114 (RNF114) and similar proteins

RNA

  1. NR_153838.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two 5' exons and an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF502145, AK148290, AK163062
    Related
    ENSMUST00000127939.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    167334565..167358093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001356496.1: Suppressed sequence

    Description
    NM_001356496.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ET26.2 GenPept UniProtKB/Swiss-Prot:Q9ET26

Gene LinkOut

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