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Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 [ Mus musculus (house mouse) ]

Gene ID: 81489, updated on 23-Jun-2021

Summary

Official Symbol
Dnajb1provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B1provided by MGI
Primary source
MGI:MGI:1931874
See related
Ensembl:ENSMUSG00000005483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsp; DjB1; Hdj1; HSPF1; Hsp40; 0610007I11Rik
Summary
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in testis adult (RPKM 83.7), thymus adult (RPKM 27.3) and 28 other tissues See more
Orthologs
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Genomic context

See Dnajb1 in Genome Data Viewer
Location:
8; 8 C2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84334804..84339282)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83608175..83612653)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (86132074..86135802)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D830024N08 gene Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene predicted gene, 51541 Neighboring gene predicted gene, 42029 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene protein kinase N1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in sperm head ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 1
Names
DnaJ (Hsp40) homolog, subfamily B, member 1
heat shock 40 kDa protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308227.1NP_001295156.1  dnaJ homolog subfamily B member 1 isoform 2

    See identical proteins and their annotated locations for NP_001295156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in a distinct 5' UTR and the use of an in-frame downstream start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AA794374, AC151992, AK158530, BY476619, BY658568
    Consensus CDS
    CCDS85571.1
    UniProtKB/TrEMBL
    Q3TYL7
    Related
    ENSMUSP00000148685.2, ENSMUST00000212300.2
    Conserved Domains (1) summary
    cd10747
    Location:62226
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
  2. NM_018808.3NP_061278.1  dnaJ homolog subfamily B member 1 isoform 1

    See identical proteins and their annotated locations for NP_061278.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA794374, AC151992, AK146657, BY251864, BY476619, BY658568
    Consensus CDS
    CCDS22456.1
    UniProtKB/Swiss-Prot
    Q9QYJ3
    UniProtKB/TrEMBL
    Q3TU79
    Related
    ENSMUSP00000005620.9, ENSMUST00000005620.10
    Conserved Domains (3) summary
    cd10747
    Location:162326
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1340
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:465
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84334804..84339282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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