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Bst1 bone marrow stromal cell antigen 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81506, updated on 13-Apr-2024

Summary

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Official Symbol
Bst1provided by RGD
Official Full Name
bone marrow stromal cell antigen 1provided by RGD
Primary source
RGD:620344
See related
Ensembl:ENSRNOG00000003064 AllianceGenome:RGD:620344
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ADP-ribosyl cyclase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of neutrophil chemotaxis; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in uropod. Predicted to be extrinsic component of membrane. Predicted to be active in plasma membrane. Orthologous to human BST1 (bone marrow stromal cell antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 247.1), Spleen (RPKM 125.9) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71466179..71482671, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67253706..67270203, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71798218..71814540, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 Neighboring gene CD38 molecule Neighboring gene uncharacterized LOC108352765 Neighboring gene F-box and leucine-rich repeat protein 5 Neighboring gene cytochrome c, somatic pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CD157 is an important mediator of neutrophil adhesion and migration. Funaro A, et al. Blood, 2004 Dec 15. PMID 15328157
  2. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Okuyama Y, et al. Biochem Biophys Res Commun, 1996 Nov 21. PMID 8941363
  3. Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans. Furuya Y, et al. Gene, 1995 Nov 20. PMID 8522202
  4. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Kaisho T, et al. Proc Natl Acad Sci U S A, 1994 Jun 7. PMID 8202488, Free PMC Article
  5. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. Hirata Y, et al. FEBS Lett, 1994 Dec 19. PMID 7805847

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating ISO
Inferred from Sequence Orthology
more info
  
enables phosphorus-oxygen lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in uropod IEA
Inferred from Electronic Annotation
more info
  
located_in uropod ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Names
ADP-ribosyl cyclase 2
BST-1
bone marrow stromal antigen 1
cADPr hydrolase 2
cyclic ADP-ribose hydrolase 2
NP_110475.1
XP_038948409.1
XP_038948410.1
XP_038948411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030848.2 → NP_110475.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

    See identical proteins and their annotated locations for NP_110475.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q63072
    UniProtKB/TrEMBL
    A6IJP1, F1LSX3
    Related
    ENSRNOP00000004094.6, ENSRNOT00000004094.7
    Conserved Domains (1) summary
    pfam02267
    Location:41 → 269
    Rib_hydrolayse; ADP-ribosyl cyclase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    71466179..71482671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092482.2 → XP_038948410.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X2

    UniProtKB/TrEMBL
    F1LSX3
    Conserved Domains (1) summary
    pfam02267
    Location:41 → 238
    Rib_hydrolayse; ADP-ribosyl cyclase

  2. XM_039092481.2 → XP_038948409.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1

    Conserved Domains (1) summary
    pfam02267
    Location:41 → 236
    Rib_hydrolayse; ADP-ribosyl cyclase

  3. XM_039092483.2 → XP_038948411.1  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X3

    Conserved Domains (1) summary
    cl08346
    Location:41 → 179
    Rib_hydrolase; ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38

RNA

  1. XR_005493016.2 RNA Sequence

  2. XR_005493017.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63072.1 GenPept UniProtKB/Swiss-Prot:Q63072

Gene LinkOut

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