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MOB2 MOB kinase activator 2 [ Homo sapiens (human) ]

Gene ID: 81532, updated on 7-Apr-2024

Summary

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Official Symbol
MOB2provided by HGNC
Official Full Name
MOB kinase activator 2provided by HGNC
Primary source
HGNC:HGNC:24904
See related
Ensembl:ENSG00000182208 MIM:611969; AllianceGenome:HGNC:24904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCCA2
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in skin (RPKM 12.1), endometrium (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11p15.5
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1469448..1486779, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1543884..1615049, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1490678..1508009, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1374637-1375384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380465-1380966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380967-1381466 Neighboring gene long intergenic non-protein coding RNA 2689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3054 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1405373-1405546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3055 Neighboring gene MPRA-validated peak1160 silencer Neighboring gene BR serine/threonine kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1458078-1458816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1469339-1469838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1474249-1474958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1479210-1479772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1520757-1521279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1528327-1529160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1529995-1530826 Neighboring gene uncharacterized LOC124902607 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534293-1534794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534795-1535294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541250-1541750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541751-1542251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1547587-1548086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1553250-1553750 Neighboring gene uncharacterized LOC124902608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1576597-1577394 Neighboring gene dual specificity phosphatase 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling. Jiang K, et al. Cell Death Dis, 2020 Apr 14. PMID 32286266, Free PMC Article
  2. Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2. Wu W, et al. Oncol Rep, 2015 May. PMID 25779224
  3. Regulation of DNA damage responses and cell cycle progression by hMOB2. Gomez V, et al. Cell Signal, 2015 Feb. PMID 25460043, Free PMC Article
  4. Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721. Leng JJ, et al. World J Gastroenterol, 2012 Dec 28. PMID 23326134, Free PMC Article
  5. Gene expression profile in Alzheimer's brain screened by molecular indexing. Doyu M, et al. Brain Res Mol Brain Res, 2001 Feb 19. PMID 11223154

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling.
    Title: MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling.
  2. The altered cell-matrix adhesion and cell motility induced by hMOB2 expression was caused by the assembly of focal adhesions.
    Title: Modulation of tumor cell migration, invasion and cell-matrix adhesion by human monopolar spindle-one-binder 2.
  3. hMOB2 interacts with RAD50, facilitating the recruitment of the MRE11-RAD50-NBS1 (MRN) DNA damage sensor complex and activated ATM to DNA damaged chromatin.
    Title: Regulation of DNA damage responses and cell cycle progression by hMOB2.
  4. MOB2 overexpression induces apoptosis and inhibits the growth of human hepatic cancer cells
    Title: Growth-inhibitory effects of MOB2 on human hepatic carcinoma cell line SMMC-7721.
  5. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
    Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
  6. Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings.
    Title: Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  8. Binds to and stimulates the kinase activity of the related human serine-threonine kinases NDR1 and NDR2.
    Title: Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MOB kinase activator 2
Names
MOB2 Mps One Binder homolog
Mps one binder kinase activator-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172223.3 → NP_001165694.1  MOB kinase activator 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091196, AK296658, AW874617, BC047291, DC413532
    Consensus CDS
    CCDS53591.1
    UniProtKB/Swiss-Prot
    Q70IA6
    Related
    ENSP00000328694.6, ENST00000329957.7
    Conserved Domains (1) summary
    pfam03637
    Location:63 → 231
    Mob1_phocein; Mob1/phocein family

  2. NM_053005.5 → NP_443731.2  MOB kinase activator 2 isoform 2

    See identical proteins and their annotated locations for NP_443731.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AW874617, BC047291, BC067785, BP388313, DC413532, HY032250
    UniProtKB/Swiss-Prot
    B4DKP3, Q70IA6, Q96M67
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 200
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1469448..1486779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791792.1 Reference GRCh38.p14 PATCHES

    Range
    203714..274494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333117.1 → XP_054189092.1  MOB kinase activator 2 isoform X3

  2. XM_054333119.1 → XP_054189094.1  MOB kinase activator 2 isoform X5

  3. XM_054333116.1 → XP_054189091.1  MOB kinase activator 2 isoform X2

  4. XM_054333115.1 → XP_054189090.1  MOB kinase activator 2 isoform X1

  5. XM_054333120.1 → XP_054189095.1  MOB kinase activator 2 isoform X6

  6. XM_054333121.1 → XP_054189096.1  MOB kinase activator 2 isoform X7

  7. XM_054333118.1 → XP_054189093.1  MOB kinase activator 2 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    1543884..1615049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370056.1 → XP_054226031.1  MOB kinase activator 2 isoform X9

  2. XM_054370058.1 → XP_054226033.1  MOB kinase activator 2 isoform X11

  3. XM_054370055.1 → XP_054226030.1  MOB kinase activator 2 isoform X8

  4. XM_054370059.1 → XP_054226034.1  MOB kinase activator 2 isoform X12

  5. XM_054370060.1 → XP_054226035.1  MOB kinase activator 2 isoform X13

  6. XM_054370057.1 → XP_054226032.1  MOB kinase activator 2 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q70IA6.1 GenPept UniProtKB/Swiss-Prot:Q70IA6

Gene LinkOut

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