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GFOD2 Gfo/Idh/MocA-like oxidoreductase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 81577, updated on 3-Apr-2024

Summary

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Official Symbol
GFOD2provided by HGNC
Official Full Name
Gfo/Idh/MocA-like oxidoreductase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28159
See related
Ensembl:ENSG00000141098 MIM:619933; AllianceGenome:HGNC:28159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable nucleotide binding activity and oxidoreductase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in esophagus (RPKM 4.4), brain (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

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See GFOD2 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67674536..67719316, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73469304..73514085, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67708439..67753219, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10979 Neighboring gene chromosome 16 open reading frame 86 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67710969-67711925 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67711926-67712881 Neighboring gene enkurin domain containing 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:67717419-67718618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10980 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:67743233-67744011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67744012-67744789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7624 Neighboring gene RAN binding protein 10 Neighboring gene Sharpr-MPRA regulatory region 12647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67839586-67840206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67840207-67840826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7626 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67851021-67851203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67859393-67860253

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effect of a GFOD2 variant on responses in total and LDL cholesterol in Mexican subjects with hypercholesterolemia after soy protein and soluble fiber supplementation. Guevara-Cruz M, et al. Gene, 2013 Dec 15. PMID 24064143
  2. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Waterworth DM, et al. Arterioscler Thromb Vasc Biol, 2010 Nov. PMID 20864672, Free PMC Article
  3. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variation in the GFOD2 gene contributes to the genetic basis for a differential response to a cholesterol- or lipid-lowering diet.
    Title: Effect of a GFOD2 variant on responses in total and LDL cholesterol in Mexican subjects with hypercholesterolemia after soy protein and soluble fiber supplementation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23802, FLJ39316, MGC11335

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-fructose oxidoreductase domain-containing protein 2
Names
glucose-fructose oxidoreductase domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243650.2 → NP_001230579.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an unspliced coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010530, AK096635, BQ003788, BQ437486, DC368734, DC381447
    Consensus CDS
    CCDS59268.1
    UniProtKB/Swiss-Prot
    Q3B7J2
    Related
    ENSP00000478260.1, ENST00000602279.2
    Conserved Domains (1) summary
    cl21454
    Location:7 → 86
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_030819.4 → NP_110446.3  glucose-fructose oxidoreductase domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_110446.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK225997, BC000757
    Consensus CDS
    CCDS10845.1
    UniProtKB/Swiss-Prot
    Q3B7J2, Q69YL9, Q6UXX6, Q7L648, Q8TE86, Q9BQ07, R4GNG5
    Related
    ENSP00000268797.7, ENST00000268797.12
    Conserved Domains (1) summary
    COG0673
    Location:1 → 364
    MviM; Predicted dehydrogenase [General function prediction only]

RNA

  1. NR_027398.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of multiple upstream ORFs that are predicted to interfere with translation of the longest ORF; translation of these upstream ORFs renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC000757

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67674536..67719316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434723.1 → XP_047290679.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3B7J2, Q69YL9, Q6UXX6, Q7L648, Q8TE86, Q9BQ07, R4GNG5

  2. XM_047434724.1 → XP_047290680.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3B7J2, Q69YL9, Q6UXX6, Q7L648, Q8TE86, Q9BQ07, R4GNG5

  3. XM_006721288.5 → XP_006721351.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006721351.1

    UniProtKB/TrEMBL
    B3KRH8
    Conserved Domains (1) summary
    COG0673
    Location:15 → 259
    MviM; Predicted dehydrogenase [General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73469304..73514085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314059.1 → XP_054170034.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3B7J2, Q69YL9, Q6UXX6, Q7L648, Q8TE86, Q9BQ07, R4GNG5

  2. XM_054314060.1 → XP_054170035.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3B7J2, Q69YL9, Q6UXX6, Q7L648, Q8TE86, Q9BQ07, R4GNG5

  3. XM_054314061.1 → XP_054170036.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7J2.1 GenPept UniProtKB/Swiss-Prot:Q3B7J2

Gene LinkOut

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