Adar adenosine deaminase, RNA-specific [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adarprovided by RGD
Official Full Name: adenosine deaminase, RNA-specificprovided by RGD
Primary source: RGD:71099
See related: Ensembl:ENSRNOG00000020744 AllianceGenome:RGD:71099
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of protein kinase activity by regulation of protein phosphorylation; and nucleocytoplasmic transport. Predicted to act upstream of or within several processes, including gene silencing by miRNA; hematopoietic stem cell homeostasis; and immune system development. Located in nuclear speck and nucleolus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 163.5), Heart (RPKM 142.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177436076..177475969)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175138391..175178280)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189045551..189085448)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:479064 (e-PCR)
- UniSTS:479064

Adar (e-PCR), detects polymorphism
- UniSTS:479064

AA964848 (e-PCR)
- UniSTS:248443

AI710840 (e-PCR)
- UniSTS:243418

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA adenosine deaminase activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA adenosine deaminase activity	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RISC complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within RISC complex assembly	ISO Inferred from Sequence Orthology more info
involved_in RNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine to inosine editing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenosine to inosine editing	ISO Inferred from Sequence Orthology more info
involved_in adenosine to inosine editing	ISO Inferred from Sequence Orthology more info
involved_in adenosine to inosine editing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within base conversion or substitution editing	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in definitive hemopoiesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within definitive hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of post-transcriptional gene silencing by regulatory ncRNA	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing by regulatory ncRNA	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in pre-miRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	IEA Inferred from Electronic Annotation more info
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in somatic diversification of immune receptors via somatic mutation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic diversification of immune receptors via somatic mutation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of supraspliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of supraspliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of supraspliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: double-stranded RNA-specific adenosine deaminase

Names: DRADA

NP_112268.1

EC 3.5.4.37

XP_006232836.1

EC 3.5.4.37

XP_006232837.1

EC 3.5.4.37

XP_006232838.1

EC 3.5.4.37

XP_006232840.1

EC 3.5.4.37

XP_038959138.1

EC 3.5.4.37

XP_063138689.1

EC 3.5.4.37

XP_063138690.1

EC 3.5.4.37

XP_063138691.1

EC 3.5.4.37

XP_063138692.1

EC 3.5.4.37

XP_063138693.1

EC 3.5.4.37

XP_063138694.1

EC 3.5.4.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031006.1 → NP_112268.1 double-stranded RNA-specific adenosine deaminase

See identical proteins and their annotated locations for NP_112268.1

Status: PROVISIONAL

Source sequence(s)

U18942

UniProtKB/Swiss-Prot

P55266

UniProtKB/TrEMBL

A6J6H2, G3V8T3

Related

ENSRNOP00000028181.2, ENSRNOT00000028181.6

Conserved Domains (4) summary

smart00358
Location:454 → 519

DSRM; Double-stranded RNA binding motif

smart00552
Location:785 → 1168

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:137 → 203

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:245 → 309

z-alpha; Adenosine deaminase z-alpha domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177436076..177475969

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282623.1 → XP_063138693.1 double-stranded RNA-specific adenosine deaminase isoform X7
XM_063282621.1 → XP_063138691.1 double-stranded RNA-specific adenosine deaminase isoform X8
XM_006232775.5 → XP_006232837.1 double-stranded RNA-specific adenosine deaminase isoform X2

UniProtKB/TrEMBL

A6J6H2, G3V8T3

Conserved Domains (4) summary

smart00358
Location:462 → 527

DSRM; Double-stranded RNA binding motif

smart00552
Location:767 → 1150

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:145 → 211

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:253 → 317

z-alpha; Adenosine deaminase z-alpha domain
XM_039103210.2 → XP_038959138.1 double-stranded RNA-specific adenosine deaminase isoform X4

UniProtKB/TrEMBL

A6J6H2, G3V8T3

Conserved Domains (6) summary

smart00552
Location:754 → 1137

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:145 → 211

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:253 → 317

z-alpha; Adenosine deaminase z-alpha domain

cd19913
Location:421 → 491

DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)

cd19915
Location:640 → 710

DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins

cl00054
Location:532 → 602

DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
XM_006232778.4 → XP_006232840.1 double-stranded RNA-specific adenosine deaminase isoform X7

See identical proteins and their annotated locations for XP_006232840.1

Conserved Domains (3) summary

smart00358
Location:209 → 274

DSRM; Double-stranded RNA binding motif

smart00552
Location:540 → 923

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

cl02659
Location:1 → 64

z-alpha; Adenosine deaminase z-alpha domain
XM_063282622.1 → XP_063138692.1 double-stranded RNA-specific adenosine deaminase isoform X9
XM_006232774.5 → XP_006232836.1 double-stranded RNA-specific adenosine deaminase isoform X1

UniProtKB/TrEMBL

A0A8I6AEC1, A6J6H2, G3V8T3

Related

ENSRNOP00000090863.1

Conserved Domains (4) summary

smart00358
Location:462 → 527

DSRM; Double-stranded RNA binding motif

smart00552
Location:793 → 1176

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:145 → 211

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:253 → 317

z-alpha; Adenosine deaminase z-alpha domain
XM_063282620.1 → XP_063138690.1 double-stranded RNA-specific adenosine deaminase isoform X6
XM_006232776.5 → XP_006232838.1 double-stranded RNA-specific adenosine deaminase isoform X3

UniProtKB/TrEMBL

A6J6H2, G3V8T3

Conserved Domains (4) summary

smart00358
Location:454 → 519

DSRM; Double-stranded RNA binding motif

smart00552
Location:759 → 1142

ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

pfam02295
Location:137 → 203

z-alpha; Adenosine deaminase z-alpha domain

cl02659
Location:245 → 309

z-alpha; Adenosine deaminase z-alpha domain
XM_063282619.1 → XP_063138689.1 double-stranded RNA-specific adenosine deaminase isoform X5
XM_063282624.1 → XP_063138694.1 double-stranded RNA-specific adenosine deaminase isoform X10